use of dmso in drug preparation

Dimethyl sulfoxide (‌DMSO) ‌ is widely used in drug preparation, ‌ mainly includes improving solubility and permeability of drugs, ‌ developing new routes of drug delivery, ‌ increasing local drug content and reducing side effects of drugs. ‌

As a weak oxidizing agent, ‌ is soluble and permeable to many drugs, ‌ which makes DMSO an important solvent in drug preparation. ‌DMSO itself also has anti-inflammatory, ‌ analgesic, ‌ promote blood circulation and wound healing, ‌ diuretic and sedative effects, ‌ can increase drug absorption and improve curative effect. ‌ When the drug is dissolved in DMSO, ‌ does not need to be taken orally or injected, ‌ can be directly applied on the skin to penetrate into the body, ‌ not only opens up a new way of drug delivery, ‌ but also increases the local drug content in the disease area, ‌ reduces the harm to other parts of the body. ‌ In addition, ‌DMSO has the property of dissolving keratin, ‌ makes it have remarkable effect in improving the therapeutic effect of drugs, ‌ especially in inhibiting the growth of tumor. ‌

There are various production methods for DMSO, ‌ including methanol carbon disulfide process, ‌ hydrogen peroxide process, ‌ nitrogen dioxide process, etc. ‌ these methods provide possibilities for large-scale production of DMSO. ‌ The refining methods include vacuum distillation, ‌ and CaH2 heating, ‌ molecular sieve dehydration, ‌ to ensure the purity and quality of DMSO. ‌

Despite the many advantages of DMSO, ‌, there are also safety precautions that need to be taken during use. ‌ should be avoided long-term skin contact with DMSO, ‌ because of its small molecular weight, ‌ easily absorbed through the skin, ‌ may lead to local skin irritation, ‌ itching, ‌ burning sensation. ‌ At the same time, ‌ should also avoid inhaling DMSO, ‌ to avoid nausea, ‌ vomiting and other uncomfortable symptoms. ‌

The application of DMSO in drug preparation not only improves the solubility and permeability of the drug, ‌ opens up a new route of drug delivery, ‌ but also increases the local drug content in the disease area and ‌ reduces the side effects of the drug on the body. ‌ However, ‌ requires safety precautions during use and ‌ to avoid possible side effects. ‌
The role of dimethyl sulfoxide in pharmaceutical
Colorless viscous liquid. Flammable, almost odorless, bitter, hygroscopic. In addition to petroleum ether, it can dissolve general organic solvents.
Strong hygroscopic, at 20 ° C, when the relative humidity is 60%, it can absorb 70% of its own weight from the air. The product is a weak oxidizing agent, and the non-aqueous dimethyl sulfoxide is non-corrosive to metals.
DMSO is soluble and permeable to many drugs, and it also has anti-inflammatory, analgesic, promoting blood circulation and wound healing, diuretic and sedative effects, and can increase drug absorption and improve curative effect. The drug is dissolved in DMSO, and can permeate the human body without oral administration or injection when applied on the skin, opening up a new way of drug delivery, and more importantly, increasing the local drug content in the disease area and reducing the harm of drugs in other organs of the body.