polyvinylpyrrolidone pvp price:The latest price is 39 yuan per kg -76 yuan per kg, divided into pvp k15 k25 k60 k87 k90 and other different levels of price difference, please contact me for details.
CAS NO. 9003-39-8
Appearance: white to milky white free flowing powder, odorless or slightly characteristic odor;
Main properties: non-toxic, non-irritating, hygroscopic, easily soluble in water, alcohol, amine and other organic solvents, with excellent solubility, film formation, chemical stability, physiological inertia, adhesion and complexing ability.
Product standard: USP/NF, EP, JP, BP,
Specification model: K value is calculated according to polymer molecular weight and aqueous solution viscosity, which is divided into the following models:
pvp k series | K value | Viscous average molecular weight Mv | Mainly used |
K12 series | 10.2 – 13.8 | 3,000 – 7,000 | It is used as a solubilizer, dispersant, and crystallization inhibitor in liquid formulations. |
K15 series | 12.75 – 17.25 | 8,000 – 12,000 | |
K17 series | 15.3 – 18.36 | 10,000 – 16,000 | |
K25 series | 22.5 – 27.0 | 30,000 – 40,000 | As a binder, film former, solubilizer, suspension stabilizer, dispersant in solid and liquid dosage forms. |
K30 series | 27 – 32.4 | 45,000 – 58,000 | |
K60 series | 54 – 64.8 | 270,000 – 400,000 | It is used as a binder, thickener, and suspension stabilizer in formulations. |
K90 series | 81 – 97.2 | 1,000,000 – 1,500,000 |
pvp K series products have the application characteristics of bonding, film formation, dispersion and thickening, and have a very wide range of uses in the field of pharmaceutical preparations, and are one of the three new pharmaceutical excipients advocated internationally.
function | Main application characteristics in the formulation |
Adhesive | Preferred binder for solid dosage forms for wet granulation, dry granulation and direct compression as well as fluidized bed granulation, It is especially suitable for the process of immediate-release preparation and anhydrous preparation, as well as drugs with poor water solubility, water sensitivity and poor compressibility, which can effectively improve the compressibility of particles, improve the adhesion and hardness of tablets, and promote drug release; |
Solubilizer | increase the solubility and improve the bioavailability of poorly soluble drug formulations; |
Dispersion or co-abrasives | As a solid dispersion carrier, it is used for the solubilization of insoluble drugs, and forms co-precipitation or co-grinding solid dispersions with insoluble drugs; |
Active ingredient stabilizer | It forms an amorphous dispersed complex with the drug to enhance the stability of the drug; |
Suspension stabilizer | increase suspension stabilization of oral liquid formulations; |
Coating film formers | coating materials, auxiliary film-forming agents and pore-forming agents and pigment dispersants; Reduce the viscosity of the coating solution, enhance the flexibility of the coating film and the binding ability to the surface of the core of the sheet, and improve the dispersion and ductility of the lake and the opacifier; |
Crystallization inhibition and thickening | Viscosity modifiers and drug co-solubilization stabilization for liquid formulations; prolongs the duration of drug action and lubrication; |
Pore-forming agents | It is used to form water-soluble pores in sustained-release and taste-masking solid preparations to regulate the dissolution rate and release rate of drugs |
other | capsule flow aids; Stabilizers for enzymes and heat-sensitive drugs; Topical preparations moisturizing, viscosifying, film-forming; All kinds of food and health products |
