PVP has good bonding properties and strong dissolution ability. PVP formed tablets, after taking in the digestive tract, the first rapid dissolution, is the local expansion and disintegration of the tablets, the release of drug fragments, and then accelerate the dissolution and absorption of the drug, play a rapid role in the efficacy of the drug. PVP is soluble in water and most organic solvents, which is particularly important for drugs with few solvents to choose from. It is for these reasons that PVP has been widely used in pharmaceutical tablets, especially abroad.
coprecipitant
Another important use of PVP as drug excipients is co-precipitation agent, some drugs have good efficacy, but its fatal disadvantage is that the solubility in water is very small, resulting in its bioavailability is greatly reduced, the use of some water-soluble substances with these drugs co-precipitation, and then improve the solubility and dissolution rate of drugs, to reduce the dose, improve the efficacy of the effect. As a co-precipitant of insoluble drugs, PVP is being widely used.
Bonding agent, solvent enhancer, disintegrator, delay agent, etc
In solid drugs, PVP can be used as adhesive, solubilizer, disintegrator, and delay agent, and can also be used as drug film coating, capsule shell and controlled release film. The drug film coat and capsule shell made of PVP are not easy to break in a dry environment, and the appropriate amount of PVP and other insoluble polymers together make permeable films of different thickness and different pore sizes, which can adjust the rate of drug passing through the film, and then achieve the effect of controlled release.
