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Product Advantage
1. Neutral property
Anhydrous piperazine is weakly basic but behaves as a relatively neutral and stable system under normal usage conditions. It is not prone to vigorous reactions with most common substances, which gives it good compatibility in various formulations.
2. Good chemical stability
It has a stable molecular structure and does not easily decompose or undergo side reactions under normal temperature and pressure or typical industrial conditions, making it suitable for long-term storage and use.
3. Good solubility in water and various solvents
Due to the presence of two nitrogen atoms and strong polarity, it has excellent hydrophilicity, dissolving readily in water and also showing good solubility in certain polar organic solvents, which facilitates its application in different systems.
4. Strong overall applicability
Thanks to its combination of neutrality, stability, and good solubility, it is widely used in pharmaceuticals, surfactants, plastic additives, and rubber additives, with strong versatility across multiple industries.
Technical Parameters
Chemical name | Diethyenediamine,alsoknown as piperazine,piperazine. |
Molecuarformula | C₄H₁₀N₂ |
CAS NO | 110-85-0 |
Physical and chemica properties | White crystal,easy to damp,with strong alkaline,easyto dissolve in water and glycerol. |
Melting point | 106.6℃ |
Boiling point | 148.5℃ |
Water content | ≤1% |
Density | 0.876(20/4℃) |
Product Uses
In the pharmaceutical field, anhydrous piperazine can be used as a pharmaceutical intermediate for the production of anthelmintic drugs, analgesics, antitumor agents, antibacterial drugs, antiallergic drugs, antidepressants, and antiemetics. Phenylpiperazine derivatives can also be absorbed by the human body and mimic the secretion of dopamine, an important neurotransmitter, thereby helping to stabilize and regulate mood.
In the field of organic chemistry, anhydrous piperazine is soluble in water, alcohols, and other liquids, and can react with acids. When formulated in appropriate proportions, it can be used in the production of surfactants, flame retardants, and compound additives.
In the agrochemical field, when added to pesticides, it can effectively control plant diseases and insect pests and protect crops. It is used in the production of fungicides and insecticides.
FAQ
What is the mechanism of action of anhydrous piperazine?
The mechanism of piperazine is that it blocks cholinergic receptors at the neuromuscular junction, thereby inhibiting the transmission of nerve impulses and the excitatory effect of acetylcholine. As a result, parasites become paralyzed without prior excitation, making it relatively safe in use.After oral administration, it is rapidly absorbed from the gastrointestinal tract. A portion is metabolized in the body, while the remainder is excreted via the kidneys. Its various salts all convert into piperazine hexahydrate in solution, and their absorption and excretion are generally similar, although the excretion rate varies significantly among individuals.
What safety precautions should be taken when handling anhydrous piperazine due to its chemical reactivity?
Anhydrous piperazine has a certain degree of chemical reactivity and may pose hazards when mixed with other chemicals. Contact or mixing with strong oxidizing agents, strong acids, strong bases, and other incompatible substances should be avoided.When handling anhydrous piperazine, precautions should be taken to prevent sparks, static electricity, and other fire and explosion risks.
