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Ergothioneine

Ergothioneine – Cell-Level Antioxidant for Premium Skincare
Ergothioneine (CAS 497-30-3) is a white to off-white crystalline powder produced via patented bio-fermentation (99% purity). This natural, potent antioxidant penetrates deep into cells to scavenge free radicals at the mitochondrial source. It offers outstanding heat stability, no irritation, and water solubility for easy formulation. With anti-aging, anti-photoaging, anti-inflammatory, and skin-brightening benefits, it is a core active in high-end skincare.
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Product Advantage

  • Mitochondrial-Targeted Antioxidant

Ergothioneine is transported into mitochondria via OCTN1, directly scavenging ROS where cellular damage begins. It protects DNA, proteins, and lipids from oxidation more effectively than common antioxidants like glutathione.

Keywords: ergothioneine antioxidant, mitochondrial ROS scavenger

  • Patented Bio-Fermentation & High Purity

Our exclusive fermentation process yields 99% pure, non-GMO ergothioneine without organic solvents. It is COSMOS‑compatible, sustainable, and free from animal or plant residues.

Keywords: bio-fermented ergothioneine, high purity ergothioneine

  • Exceptional Thermal & pH Stability

Ergothioneine remains stable at high temperatures (up to 100°C) and across pH 2–12. It does not degrade during hot processing or long-term storage, ensuring consistent performance in creams, serums, and sunscreens.

Keywords: stable antioxidant for skincare, heat resistant antioxidant

  • Multi‑Functional Anti‑Aging & Brightening

Clinical studies show ergothioneine reduces UV‑induced photoaging, suppresses inflammation (IL‑6, TNF‑α), and inhibits melanin synthesis. It visibly improves skin tone, firmness, and radiance.

Keywords: anti-aging peptide, skin brightening antioxidant

  • Water‑Soluble & Formulation Friendly

Easily dissolved in water at low temperatures, ergothioneine integrates into any water‑based system without heating. It is non‑irritating (0% reaction in patch test) and compatible with most cosmetic ingredients.

Keywords: water soluble antioxidant, clean beauty ingredient

Technical Parameters

Item

Specification

Result

Appearance

White powder or crystal

White crystal

Odor

Odorless to slight characteristic
odorr

Conforms

Assay

≥99.0%

100.00%

Purity

≥99.0%

100.00%

≥+122°

+125.6°

Loss on Drying

≤0.5%

0.1%

pH

6.0-7.5

6

Arsenic(As)

≤1.0 mg/kg

<1.0mg/kg

Lead (Pb)

≤1.0mg/kg

<1.0mg/kg

Cadmium(Cd)

≤0.3mg/kg

Not detected

Mercury(Hg)

≤0.2 mg/kg

Not detected

Total Aerobic Count

≤1000 CFU/g

<10 CFU/g

Mold&Yeast Count

≤100 CFU/g

<10 CFU/g

Coliforms

≤3.0MPN/g

<3.0 MPN/g

Salmonella

Not detected per 25g

Not detected

Staphylococcus aureus

Not detected per 25g

Not detected

Pseudomonas aeruginosa

Not detected per 25g

Not detected

Product Uses

  • Anti‑Aging Serums

At 0.05%-5%, ergothioneine penetrates deeply to protect mitochondria from oxidative stress. It reduces fine lines, improves elasticity, and restores radiance. Ideal for daily use under moisturizer.

  • Brightening & Spot Correction Creams

Ergothioneine inhibits melanin synthesis and reduces UV‑induced pigmentation. At 0.02–0.1%, it visibly lightens dark spots and evens skin tone without irritation.

  • Sunscreens & After‑Sun Lotions

Its photostability and anti‑inflammatory action protect against UV damage. Added at 0.02–0.1%, it reduces redness, prevents photoaging, and supports DNA repair after sun exposure.

  • Eye Creams for Dark Circles & Puffiness

Delicate eye area benefits from ergothioneine’s ability to reduce oxidative stress and inflammation. At 0.02–0.1%, it diminishes dark circles and under‑eye puffiness.

  • Repair Night Creams & Sleeping Masks

Overnight, ergothioneine works at the cellular level to neutralize accumulated free radicals. It boosts collagen preservation and strengthens the skin barrier, leaving skin firmer by morning.

  • Soothing Gels & Post‑Procedure Care

With strong anti‑inflammatory properties, ergothioneine calms irritated skin. At 0.02–0.1%, it accelerates barrier recovery after peels or laser treatments, reducing redness and discomfort.

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