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What is PVP va64?

Views: 0     Author: Site Editor     Publish Time: 2024-02-20      Origin: Site

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Chemical description
Product Name: Copovidone (PVP VA 64)
Brand Name: BOVIDONEVA64
CAS number: 25086-89-9
Chemical name: vinylpyrrolidone/vinyl acetate copolymer
CEP Registration number: 2019-199
DMF registration number: 33953

Physicochemical properties
White to light yellow hygroscopic powder, good fluidity, hygroscopicity lower than POvidone;
Soluble in water, ethanol and other organic solvents, the glass transition temperature is low;
It is an excellent film forming agent;

Product standard
Meets USP/NF, EP, JP, BP standards

Typical characteristic

Electron microscope scan of copovidone

specification

serial number test item european pharmacopeas standards
1 viscosity 27.0-33.0
2 loss on drying ≤5.0%
3 Impurity A (2-pyrrolidone) ≤0.5%
4 peroxide ≤400ppm
5 heavy metal ≤10ppm
6 Impurity B (1-vinyl-2-pyrrolidone) ≤10ppm
7 Impurity C (vinyl acetate) ≤10ppm
8 Elemental impurity accord with ICH Q3D

Apply
Used as a dry adhesive for direct pressing tablets, adhesives for tablets, capsules and granules by wet process;
As an excellent film forming agent, it is used in the coating solution of tablets, particles, pellets and sugar-coated core and in the spray for local use. The film coating and spray film prepared with this product have good flexibility, low water absorption, high plasticity and low viscosity.
Good plasticity and low glass transition temperature make it suitable for the preparation of pharmaceutical solid dispersions by hot melt extrusion.
Improve the solubility and bioavailability of drugs;
Excellent adhesive for moisture-sensitive prescriptions;

Packaging and storage
25kg cardboard or plastic drum packing;
Store in a dry, airtight container.

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