What is POvidone K30? What does it do?

The chemical name of POvidone is polyethylpyrrolidone, POvidone K30 is a 1-vinyl-2-pyrrolidone homopolymer obtained by polymerization of pyrrolidone and pyrrolidone monomer under pressure under the action of catalyst, the molecular formula is (C6H9NO)n, where n represents the average number of 1-vinyl-2-pyrrolidone chain links. According to the calculation of anhydrous matter, nitrogen (N) should be 11.5% ~ 12.8%. According to the viscosity of solution expressed by K value, povidone products are divided into different types.

Main performance
Povidone K30 has good hygroscopicity, film formation, complexation and physiological compatibility, and has the ability to compound a variety of organic and inorganic compounds, stable to acid, salt and heat, and has a wide range of uses. It can be used as binder of tablets and particles, co-solvent and stabilizer of injections, flow aid of capsules, dispersant of liquid preparations and colorants, stabilizer of enzyme and heat-sensitive drugs, co-precipitating agent of insoluble drugs, detoxifying agent of eye drugs, lubricant and coating film agent, etc.
Main use
Povidone K30 is mainly used in the pharmaceutical industry, as one of the three new pharmaceutical excipients advocated internationally. It is mainly used as binder of tablets and granules, flow aid of capsules, detoxification and lubricant of eye drugs, co-solvent of injections, dispersant of liquid preparations, stabilizer of enzymes and heat-sensitive drugs, synthesis of PVP-I disinfection and fungicide with iodine, and also as cryopreservation agent.
Synthesis technology
450ml water is added to the reactor, the water bath is heated to 70℃, then 300ml of N-vinylpyrrolidone (NVP) is added, stirred, 2.7ml of ammonia is added (the ammonia mass percentage concentration is 27%), the pH value is 9.0, and then 100mg ammonium sulfite is added, when the temperature rises to 78℃, Add 186ml hydrogen peroxide solution continuously (31% hydrogen peroxide solution mass concentration), when the reaction temperature rises to 83 ° C, start timing, keep the polymerization temperature at 83 ° C, and stop the reaction after 5.5h.