Chemical name: polyvinylpyrrolidone and iodine complex
CTFA Name: PVP-Iodine
CAS No.: 25655-41-8
Molecular formula: (C6H9NO)n·xl
Physical properties: brown-yellow or brown-red forming powder, with a light special smell, soluble in water and ethanol, insoluble in diethyl ether and chloroform, good stability, no irritation, bacteria, viruses, fungi, mold and spores have a strong killing effect, is the first choice containing iodine fungicide.
Applications:
Polyvinylpyrrolidone iodine complex (PVP-I) has been used to study microbial decontamination of human donor eyes and inactivation of necrotic viruses in infectious hematopoietic tissue.
Biochemical/physiological effects
PVP-1 is used as an iodine sustained-release preparation that iodizes lipids and oxidizes cellular compounds such as tyrosine side chains. Used as a coating agent for carbon nanotubes to improve water solubility.
Hospital operation, injection and other skin disinfection and instrument disinfection, sterilization and sterilization.
Sterilization and disinfection of household utensils and utensils.
Sterilization for food industry and breeding industry.
Animal disease prevention and disinfection.
It has been included in the USP/EP/BP pharmacopoeia, PVP-I products are the first choice of iodine containing fungicide and health and epidemic prevention disinfectant in developed countries.
Polyvinylpyrrolidone iodine (PVP-I) is a complex formed by the combination of polyvinylpyrrolidone (PVP) and iodine. It is commonly used as an antiseptic and disinfectant agent due to its broad-spectrum antimicrobial properties. PVP-I is available in various formulations, including solutions, ointments, gels, and scrubs.
Here are some key points about PVP-I:
1. Antimicrobial Action: PVP-I exhibits potent antimicrobial activity against a wide range of microorganisms, including bacteria, viruses, fungi, and protozoa. It works by releasing free iodine, which has a germicidal effect.
2. Antiseptic and Disinfectant: PVP-I is used for wound care, surgical site preparation, and general skin disinfection. It is effective in reducing the risk of infection in cuts, burns, and abrasions.
3. Surgical Applications: PVP-I is commonly employed in pre-operative skin preparation to reduce the microbial load on the skin surface and minimize the risk of surgical site infections.
4. Topical Treatment: PVP-I can be applied topically for the treatment of various skin conditions, such as fungal infections, bacterial infections, and certain viral infections. It helps to eliminate or control the growth of microorganisms on the skin.
5. Iodine Release: PVP complex stabilizes the iodine, allowing for a slow and controlled release of free iodine over time. This sustained release ensures prolonged antimicrobial activity without causing irritation or toxicity.
6. Safety and Side Effects: PVP-I is generally considered safe when used as directed. However, some individuals may experience hypersensitivity or allergic reactions. It is important to perform a patch test before using PVP-I on a larger area of the skin.
7. Regulatory Approval: PVP-I is approved by regulatory authorities, such as the U.S. Food and Drug Administration (FDA), for its use as an antiseptic and disinfectant.
PVP-I is a widely used antimicrobial agent due to its effectiveness, safety, and versatility. However, it is always recommended to follow the instructions provided by healthcare professionals or product labels when using PVP-I products.
