Pharmaceutical solvent NMP (N-methylpyrrolidone)

N-methyl-pyrrolidinone (NMP,872-50-4,1-Methyl-2-pyrrolidinone) abbreviated as NMP, molecular formula :C5H9NO, English: 1-Methyl-2-Pyrrolidinone,NMP appearance is colorless to light yellow transparent liquid, slightly ammonia odor, NMP is miscible with water in any proportion, soluble in ether, acetone and ester, halogenated hydrocarbon, aromatic and other organic solvents, almost completely mixed with all solvents, NMP boiling point 204 ° C, flash point 91 ° C, strong moisture absorption, chemical stability, no corrosion to carbon steel, aluminum, slightly corrosive to copper. NMP has the advantages of low viscosity, good chemical and thermal stability, high polarity, low volatility, and infinite miscibility with water and many organic solvents. NMP is a microdrug with an allowable limit concentration of 100PPM in the air.

Medicine & Agriculture

First, NMP is widely used as a reaction intermediate in the field of organic synthesis. Due to its high reactivity and good stability, it can participate in a variety of organic synthesis reactions, such as the synthesis of olefin and aromatic compounds.

In addition to organic synthesis, NMP also has important applications in the field of medicine. It is an effective anesthetic agent and is often used for induction and maintenance of anesthesia during surgery. Its mechanism of action is to achieve analgesic and anesthetic effects by affecting the transmission of neurotransmitters.

In addition, NMP is also widely used in the agricultural field. It can be used as a pesticide to control pests on crops. Its special structure and chemical properties enable it to interact with the nervous system of insects, thus achieving the effect of killing insects.

1, colorless liquid, ammonia taste, N-methylpyrrolidone NMP toxicity is small. It can be miscible with water and soluble in most organic solvents such as ether and acetone. It can dissolve most organic and inorganic compounds, polar gases, natural and synthetic polymer compounds.

2, chemical properties: relatively stable in neutral solution. In 4% sodium hydroxide solution, 50% to 70% hydrolysis occurs after 8 hours. It is gradually hydrolyzed in concentrated hydrochloric acid to form 4-methylaminobutyric acid. Due to the reaction of the carbonyl group, ketone or pyrrolidone can be formed.

3, in the presence of alkali catalyst and olefin, alkylation reaction occurs at the third position. N-methylpyrrolidone is weakly basic and can form hydrochloride. To form adducts with heavy metal salts, such as nickel bromide heated to 150 ° C, to form NiBr2(C5H9ON)3, melting point 105 ° C.

NMP can be miscible with water, PVDF, positive and negative electrode materials, etc., and is widely used in the preparation of lithium batteries. When making electrode sheets, NMP is used as a solvent to fuse the binder, positive active substance, conductive agent and other materials needed for electrodes together, so that the binder is fully in contact with other substances and evenly distributed. As a solvent, the quality of NMP will directly affect the quality of pulping coating of lithium-ion batteries.

N-methylpyrrolidone NMP is an excellent advanced solvent, a polar solvent with strong selectivity and good stability, and an excellent cleaning agent for high-precision electronics, circuit boards and lithium batteries.

Other applications of NMP include:

1. In the polymer industry, NMP exists as a para-aramid polycondensation solvent.

2, insulation industry, NMP is used as a reaction and dilution solvent for polyimide paint in the insulation industry.

3, electronic materials industry, NMP in electronic materials used as IC, PCB, LED, semiconductor cleaning, mainly ultra-pure electronic chemicals.

4, petrochemical, such as butadiene extraction, isoprene extraction, synthesis gas desulfurization, acetylene recovery, lubricating oil refining, etc.

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