How do you use dmso
Dimethyl sulfoxide (DMSO) is a kind of sulfur-containing organic compound, is known as “universal solvent”, because of its unique physical and chemical properties, has been widely used in many fields. Here are some instructions on how to use DMSO:
Physical and chemical properties:
Dimethyl sulfoxide is a colorless and odorless transparent liquid at room temperature, has strong hygroscopic property, freezing point is 18.55℃, density is close to water.
Chemically, DMSO has the molecular formula (CH3)2SO, for having one hydrophilic thionyl group and two hydrophobic methyl groups in its structure, it is miscible with both aqueous solution and most organic solvents except petroleum ether. can dissolve about 80% of the compounds, including most of the water-soluble compounds and fat-soluble compounds.
Application field:
Medical field: DMSO is mainly used for drug dissolution in animal experiments, and the recommended use volume of accounts for 10%-20% of the total volume of administration. Avoid skin contact, because of the small molecular weight of DMSO, easily absorbed through the skin, may lead to local skin irritation, itching, burning sensation.
Industrial Field:
As an extraction solvent, has high selectivity in aromatic extraction, does not react with alkanes, olefins or water, is non-corrosive and is non-toxic, has low extraction temperature and simple extraction process , and can be used as back extraction.
As antifreeze, brake oil, hydraulic fluid components, its low freezing point, mixed with water, snow will release heat, suitable for cold areas.
In cell cryotherapy, DMSO is the best protective agent for cell cryotherapy. can quickly penetrate the cell membrane and enter the cell, can reduce the freezing point, can delay the cryotherapy process, can increase the intracellular ion concentration and can reduce the formation of intracellular ice crystals.
In acrylon filature, used for the polymerization of acrylonitrile, DMSO get bulk , , soft easy dyeing of artificial wool, has high solubility process simplified, , high boiling point solvent, non-toxic , easy to recycle, etc.
Method for the use of dimethyl sulfoxide
1. Solubility test
When preparing some solutions, it is necessary to test the solubility of DMSO first. The usual method is to add a reagent to a small amount of DMSO and observe whether it is completely or partially dissolved. If a variety of reagents are mixed, the corresponding mixing test should be carried out first.
2. Prepare the concentration
The concentration of DMSO is related to the specific use. In general experimental and medical applications, the concentration of DMSO should not exceed 10%. If the concentration of DMSO needs to be increased, special operations are required.
3. Dilution method
DMSO is unable to dissolve very small amounts of substances and requires proper dilution. Generally speaking, the diluent prepared with pure water is better.
4. Mixing method
The dissolution of DMSO takes a certain amount of time and usually requires mechanical agitation to speed up the process. Direct contact with DMSO in tilting containers should be avoided, and stirring should be done away from light.
Precautions for use:
When using DMSO, should follow the safe operating procedures, to avoid prolonged skin contact, to avoid irritating reaction.
In medical applications, should strictly control the use of DMSO, to avoid exceeding the toxicity ratio, to ensure the safety of experimental animals.
In industrial applications, should pay attention to the storage and transportation safety of DMSO, to avoid high temperature and fire sources.
To sum up, dimethyl sulfoxide plays an important role in many fields such as medical treatment and industry because of its unique physical and chemical properties. Observe safe operation and domain-specific guidelines when using
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