dimethyl sulfoxide function

Dimethylsulfoxide (DMSO for short) is a sulfur-containing organic compound, English Dimethylsulfoxide, molecular formula (CH3) 2SO, at room temperature is colorless odorless transparent liquid, with hypersonic flammable liquid, both high polarity, high boiling point, aprotic, water mismissibility characteristics, very low toxicity, good thermal stability, It is not mixed with alkanes, and can dissolve in water, ethanol, propanol, ether, benzene and chloroform and other most organic matter, known as “universal solvent”.

Dimethyl sulfoxide is one of the most powerful organic solvents in common use. It can dissolve most organic matter, including carbohydrates, polymers, peptides, and many inorganic salts and gases. It can dissolve solutes equal to 50-60% of its weight (other common solvents can only dissolve 10-20%), so it is important in sample management and high-speed drug screening. Under certain conditions, an explosive reaction occurs when dimethyl sulfoxide comes into contact with an acyl chloride.

Dimethyl sulfoxide is widely used as a solvent and reaction reagent, especially as a processing solvent and drawing solvent in acrylonitrile polymerization, as a polyurethane synthesis and drawing solvent, as a synthetic solvent of polyamide, polyimide and polysulfone resin, and as a solvent for aromatics, butadiene extraction and synthesis of chlorofluoraniline. In addition, in the pharmaceutical industry, dimethyl sulfoxide is also directly used as a raw material and carrier for some drugs. Dimethyl sulfoxide itself has anti-inflammatory analgesic, diuretic, sedative and other effects, and is also known as a “panacea”, often added to drugs as an active component of analgesic drugs. It has a special property that easily penetrates the skin, causing users to feel like oysters.

Dimethyl sulfoxide solution of sodium cyanide can cause cyanide poisoning through skin contact. Dso itself is less toxic. Dimethyl sulfoxide is used as an extractant by most chemical and pharmaceutical enterprises, but due to the high boiling point of DMSO, the operating temperature is too high, which causes the coking of materials, affects the recovery of dimethyl sulfoxide and equipment cleaning, and also increases energy consumption. Therefore, the recovery of DSO has become a bottleneck for its further widespread use as an extractant.

Efficacy and action of dimethyl sulfoxide

Dimethyl sulfoxide has anti-inflammatory, antiedema and local analgesic effects. This drug has a variety of anti-inflammatory mechanisms, the most important of which is the ability to inactivate hydroxyl radicals. Because hydroxyl free radicals can be produced in large quantities during the human inflammatory response, and lead to tissue necrosis.

Biological function of dimethyl sulfoxide
Anti-inflammatory effect

Inflammation is one of the body’s responses to adverse stimuli. It is usually regulated and beneficial to the body. When the body is subjected to low-intensity continuous adverse stimulation, inflammation will become uncontrollable and cause damage to the body. According to related studies, dimethyl sulfone has a significant inhibitory effect on inflammation. Dimethylsulfone has an inhibitory effect on NF-κB signaling mediated inflammation, which can reduce the transcriptional activity of B cells, inhibit the migration of p65 subunit of NF-κB to the nucleus, and block the degradation of NF-κB inhibitors. Using mice as test animals, Yu Wei et al. showed that dimethyl sulfone could inhibit the secretion of inflammatory factors and promote the expression of anti-inflammatory factors in mice. K. Amirshahrokhi et al. used rats as test animals, and the study showed that dimethyl sulfone also has a good therapeutic effect on colitis.

antioxidation

Antioxidant is the abbreviation of antioxidant free radicals, and its principle is to directly or indirectly act on oxidative free radicals to weaken the oxidative attack of free radicals on cells, so as to prevent further pathological changes in cells. Generally speaking, the level of antioxidant in the body is positively correlated with the health status of the animal. The higher the antioxidant level of the body, the better the health of the animal; On the contrary, the lower the antioxidant level of the body, it indicates that the animal is in poor health. Under normal circumstances, animals have a complete antioxidant system in the body to maintain the stability of oxidation levels in the body. Relevant studies have shown that dimethyl sulfone has the function of clearing active oxygen species and inhibiting the production of active oxygen species in the body, and it has been confirmed in some animal tests.

Therefore, dimethyl sulfoxide can improve the metabolism of the affected area, and can play an anti-edema role to a certain extent. In addition, the local analgesic effect of dimethyl sulfoxide is because it can slow down the conduction rate of peripheral nerves, through such a mechanism to obtain the analgesic effect.
Maintain health and prevent disease

Dimethyl sulfoxide is the main donor of organic sulfur in animals, and organic sulfur is an important component of many active substances in the body, so dimethyl sulfoxide can improve cell activity, maintain normal cell physiology and prevent diseases. Because dimethyl sulfone also has the effect of strengthening blood circulation, softening tissue, dredging blood vessels, and maintaining skin, some foreign countries have developed it into a health care product, and achieved good curative effect.