cross linked polyvinylpyrrolidone

Product name: Crosslinked POvidone
CAS login number: 9003-39-8
Chemical name: Cross-linked polyvinyl pyrrolidone (PVPP)
Physicochemical properties
White or milky white free flowing powder;
Insoluble in water, acid, alkali and common solvents;
It has strong expansibility in water, does not form gel after expansion, has very good co-solubility, can be complexed with polyphenols, carboxylic acids, tannins and small molecules, and is the first choice of disintegrating agent for high-end tablets;

Product standard
Comply with CP, USP/NF, EP, JP, BP standards

Typical characteristic
Apply
As a super disintegrator used in preparations, it can promote the release of active substances in tablets, capsules and granules;
The crosslinked POvidone fine powder is especially suitable for smaller tablets or directly pressed tablets, and the ultra-fine can be used as a disintegrator for fast dispersing tablets for a lubricated taste.
It can be used as adsorbent and complexing agent in preparation to improve bioavailability.
Used as a dissolution accelerator to increase the solubility of insoluble drugs.
It is widely used in the food industry as a filter aid in the production of wine, beer and juice, and polyphenols can form stable complexes, which can improve their taste and extend their shelf life; Divided into disposable and regenerative two specifications;

Molecular formula: (C6H9NO) n>1000000

Functions:

This product is also widely used in the food industry as a filter aid for brewing and vinegar production, for removing enzymes and proteins.

Crosslinking POvidone and polyphenol can form stable complexes and can be used to refine water-soluble or alcohol-containing herbal extracts and tinctures to improve the stability of plant medicine.

Crosslinked POvidone, a pharmaceutical excipient, is a water-insoluble synthetic crosslinked N-vinyl-2-pyrrolidone homopolymer.

Crosslinked POvidone is used as a tablet disintegrator

Crosslinked POvidone is a water-insoluble synthetic crosslinked N-vinyl-2-pyrrolidone homopolymer. Due to the water insolubility of the material itself, the exact molecular weight has not been determined.

Properties: Crosslinked POvidone is white or white powder; Almost odorless; It is moisture-inducing. This product is insoluble in water, ethanol or ether.

This product has a high capillary/water content, larger than the surface, strong hydration ability (HK: 5.6), high and rapid water absorption (58.5%), strong water absorption and expansion capacity, swelling coefficient of 2.25-2.30, with the same complex capacity of polyvinylpyrrolidone, can complex a variety of substances, such as phenols, iodine and so on.

Use of crosslinked POvidone:
Crosslinked POvidone is a water-insoluble tablet disintegrator used in direct tablet pressing and dry or wet pellet pressing processes with a concentration of 2-5%; Crosslinked POvidone showed high capillary activity and excellent hydration ability quickly, almost no tendency to gel. The results showed that the size of crosslinked POvidone particles strongly affected the disintegration of Jierezhitong tablets, and the disintegration of large crosslinked POvidone particles was faster than that of small ones. Crosslinked POvidone is a very good disintegrant, the use of 1-2% in the tablet, you can obtain the disintegration of other commonly used ordinary disintegrants, and has good reprocessability, that is, when recycling and processing, there is no need to add a large amount of disintegrant, known as super disintegrant.

When the crosslinked POvidone was used as disintegrator, the tablets had high hardness, short disintegration time and high dissolution rate. Strong stability, will not change with time.

Crosslinked POvidone can also be used as a dry adhesive, filler and excipient for tablets, capsules and granules. The smaller particle size can reduce the one-sided markings in the pressed tablets and improve the uniformity of the tablets. The usual dosage is 20-80mg/ tablet.

Crosslinked POvidone can also be used as a dissolution accelerator, using co-evaporation technology, can increase the solubility of the insoluble: first the appropriate solvent will be adsorbed on the crosslinked POvidone, and then the solvent will be evaporated, this technology can obtain a faster dissolution rate.
Packaging and storage
25kg cardboard or plastic drum;
Store in a dry, airtight container;
Shelf life: 2 years.