Application of chemical raw materials in medicine

Product overview
povidone
Product Name Povidone (PVP)
USP/EP name povidone
INCIPVP
CASNO.9003-39-8
Appearance White to milky white free flowing powder, odorless or slightly characteristic odor;
The main properties are non-toxic, non-irritating, hygroscopic, easily soluble in water, alcohol, amine and other organic solvents, with excellent solubility, film formation, chemical stability, physiological inertia, adhesion and complexing ability.
Product standards meet USP/NF, EP, JP, BP,
K series products have the application characteristics of bonding, film formation, dispersion and thickening, and have a very wide range of uses in the field of pharmaceutical preparations, and are one of the three new pharmaceutical excipients advocated internationally.
Crosslinked POvidone
Product Name: Crosslinked POvidone (PVPP)
USP/EP Name :crospovidone
INCI:CrosslinkedPVP

Appearance White or milky white free flowing powder, odorless or slightly characteristic odor
The main properties are easy to absorb moisture, insoluble in water, acid, alkali and general organic solvents; Water absorption is easy to expand rapidly, but does not form gel; Good fluidity and plasticity, high compressibility; Non-toxic, chemically inert.
Product standards meet USP/NF, EP, BP, JPE, CP2010
Main application
As a super disintegrator used in the preparation, the preparation can quickly swell and disintegrate, effectively improve the drug dissolution and bioavailability, and can adapt to the wet granulation and direct pressing process. Different particle size products are used in different adding processes, affecting the disintegration time and one-sided appearance of tablets.
As an adsorbent and a complexing agent, it can be used in the preparation to stabilize the active components of the drug and improve the release and bioavailability of the drug through the complexation. The drug release of different particle size products was significantly different.
It can be used as suspension stabilizer to reduce the settling of drug particles and increase the redispersing ability of settling liquid.
Application performance
The molecular structure is a highly physical crosslinked network structure with high capillary activity and rapid water absorption. The specific surface area is large, the water absorption and expansion ability is strong, but it does not form a high viscosity gel.
It has good plastic deformation and fluidity, good compressibility, and the disintegration time is rarely affected by the pressure plate force.
High reprocessing capacity and full disintegration potential after several wetting/drying cycles.
Copovidone
Product Name: Copovidone (VA64)
USP/EP name Copovidone,
INCI:PVP/VAcopolymer60/40
CASNO.25086-89-9
Appearance properties White to light yellow free flowing powder, good fluidity, tasteless or slightly characteristic odor;
Powder moisture absorption is less than K30, soluble in water, ethanol and other organic solvents, lower than K30 glass transition temperature, can form a transparent water soluble film;
Product standards meet USP3/NF, EP, BP, JPE
Main application
As an adhesive, it is suitable for tablet wet and dry granulation process and powder direct pressing process to improve the compressibility of particles;
Coating film forming agent is used for coating tablet film;
The pore-causing agent is used in odor masking formulations and sustained-release formulations.
Solvent-raising is used in solid dispersion process.
Application performance
Strong plasticity, can give the tablet good hardness, is applied to the direct tablet process of excellent dry adhesive;
Suitable for drugs with poor compressibility, improve the compressibility of drugs, and meet the requirements of direct pressing process;
Excellent adhesive for preparation of effervescent tablets and dispersion tablets;
Combined with HPMC/HPC/PVA, it can effectively improve the film elasticity and adhesion with the core, improve the coating film gloss, reduce the HPMC viscosity, improve the plasticity of cellulose film, reduce the film brittleness, and reduce the amount of plasticizer.
Suitable for plain film isolation layer base, flavor blocking formulation, slow release coating film pore-causing agent;
It has good plasticity and is suitable for the preparation of drug solid dispersion by hot melt extrusion.
It can form polymer complex with drug molecules in water through hydrogen bonding, and can be used as skeleton material of gastric retention tablets. It has good retention performance, prolongs drug release time, improves drug absorption and improves bioavailability.