1 2-hexanediol in skin care

1, 2-hexadiol is a kind of polyol, the appearance is colorless and transparent, has a mild sweet fragrance, as a cosmetic raw material, has a good bactericidal and moisturizing effect (antibacterial mechanism: can enter the cell membrane of microorganisms, and then destroy the integrity of the cell membrane, let the cell fluid penetrate out, and finally lead to the death of microorganisms), while no sensitive side effects on human skin.

Physical and chemical properties
1,2 hexadiol is soluble in water, ethanol and so on.
12 hexanediol generally refers to 1, 2-hexanediol, which mainly has a moisturizing effect on the skin. It also has an antibacterial and antiseptic effect in various skin care products and cosmetics, and can improve the user’s skin feeling. It has many effects and effects on the skin, such as moisturizing, moisturizing, antibacterial and so on.
1, moisturizing: 1, 2-hexadiol is a common moisturizing agent, with strong hygroscopic property, water retention performance is also better, can prevent excessive loss of skin moisture, moisturizing duration is relatively long.
2, moisturizing: 1, 2-hexanediol penetration is relatively strong, can penetrate deep into the skin, moisturize dry skin, keep the skin lubricated.
3, antibacterial: This substance has a good inhibitory effect on some pathogens, such as yeast, mold, etc., can reduce the stimulation of this part of the pathogens on the skin.
Safety of 1, 2-hexadiol (irritant/allergic)
Current safety of 1, 2-hexadiol · More than ten years of use · Skin irritation: almost no · Eye irritation: Severe · Skin irritation (allergy) : Almost nothing can be assumed from these results that these ingredients are generally safe in terms of cosmetic content and normal use. The following is the basis of this conclusion.
1. About skin irritation
Based on safety component review safety test data [human trial] 205 participants (42 men, 163 women) were given carbomer gel containing 15% 1, 2-hexanediol for 48 hours during induction and stimulation. Responses were scored after 72 hours, with one in 205 showing a stimulus response, but no follow-up response was observed in the 4-day repeated release patch test. · [Human trial] Skin stimulation was performed on 224 subjects (48 men, 176 women, 19-70 years old) using carbomer gel containing 0.5%, 1-hexadiol. There was also no skin irritation · [Human trials] When 56% of participants used a 10% aqueous solution of 1, 2-hexanediol, none of the participants caused skin irritation. · [Human trial] A gel preparation containing 0.5% 1, 2-hexanediol was applied to the backs of 101 participants on a 24-hour semi-closed patch without causing skin irritation. · [Human trial] The backs of 28 participants were washed with a 0.15% body wash containing 1, 2-hexanediol twice a week for 30 days, and none of them developed erythema, swelling, or dryness. Conclusion The product has no potential effect on skin irritation. Based on test data, almost no skin irritation is usually reported because no skin irritation is usually reported.
2. About eye irritation
A 1% aqueous solution of a mixture of 50% 1, 2-hexanediol and 50% octanediol is classified as severe eye irritation based on safety test data from a safety composition review
Based on the test data, severe eye irritation has been reported, so it is possible for severe eye irritation to occur.
3. About skin allergies
According to Safety Component Review Safety test data [Human trials] When 56% of participants used 10% aqueous solution of 1, 2-hexanediol, none of the participants caused skin irritation. [Human trial] The backs of 28 participants were washed with 0.15% 1, 2-hexanediol body wash twice a week for 30 days. Conclusion This product has no potential to induce skin sensitization · [Animal tests] In mouse skin sensitization tests according to OECD429 guidelines,10,50,100 percent solution of 1, 2-hexadiol was evaluated and skin sensitization was negative.