DMSO Basic information: DMSO: dimethyl sulfoxide, is a colorless and odorless transparent liquid, with strong moisture absorption, high polarity, high boiling point, good thermal stability, and water miscible characteristics, it and most organic matter can be miscible, and has the title of “universal solvent”. Melting point: 18.4 °C; Boiling point: 189°C In organic synthesis, due to the good solubility of DMSO, we often use DMSO as a reaction solvent, but it is sometimes difficult to remove it due to its high boiling point during post-processing. 1, if the reactant is stable and resistant to high temperature, it is a good solution, with the oil pump, about 60 degrees, vacuum distillation can soon be removed; 2, if the reactants are not so stable, it is obviously not advisable to use oil pumps to pull. If the solubility of the reactants is not good, then slowly add a lot of water, the…

N-methylpyrrolidone Material Safety Data Sheet Material safety data sheet Part I ChemicalsChinese name of chemical: N-methylpyrrolidoneChemical name or trade name: NMP Part II Composition/composition information Chemical name: N-methylpyrrolidoneHarmful ingredients: N-methylpyrrolidone concentration: ≧99.9%CAS No. : (EINECS number: 212-828-1)The third part is danger summary Risk category: No data availableRoute of invasion: contact (eyes and skin), ingestion (inhalation or ingestion)Health hazard: Eye: Too much contact can irritate the eyes. Skin: Prolonged or frequent contact can cause dermatitis, such as blisters, tears, edema, and/or redness of the skin. Ingestion: May cause dizziness, nausea, and/or irritation. Inhalation: Inhalation of high concentrations of this product can cause headache, dizziness, nervous confusion and/or nausea. Long-term inhalation: No life-shortening toxicity or carcinogenic effect was observed in rat tests.Environmental hazards: LC50 (light blue edible large sunfish) 832 mg/l, 22℃ LC50 (Pathead Minnow) 1072 mg/l, 22℃ LC50 (salmonfish) 3048 mg/l, 22℃Ignition hazard: This product is flammable, flash point is 99℃,…

Let’s take our attention away from the pericyclic reaction for a moment and discuss one of the reactions mentioned in the big book: This reaction, which appears on page 808 of the larger book, is an example of the Kornblum reaction, which is formally equivalent to DMSO oxidizing an alkane halide to a carbonyl compound. The reaction mechanism is very similar to Swern: As you can see, the C-H of the substrate is activated, the sigma bond electrons are “pulled” away by the formed onium ion during the reaction, and finally the onium ion has gained a pair of electrons, which are reduced to dimethyl sulfide. The R in the substrate halon can be a carbonyl group, an ester, a carboxylic acid, or an aromatics activated by an electron-withdrawing group, and the halogen atom can be Cl, Br, I. Under optimized conditions, the substrate can also be extended to aliphatic…

DMSO is widely used in biological and chemical experiments, almost irreplaceable, but how to safely use and protect DMSO? Main uses of DMSO: 1, used as a drug solvent. 2, for the cryopreservation of cells, including stem cells, embryos and various cell cultures. 3. As osmotic accelerators in topical pharmaceutical preparations: diclofenac sodium topical solution (approved in the United States for the treatment of signs and symptoms of osteoarthritis) and iodouridine topical solution (approved in Europe for the treatment of shingles). 4, used as a drug to relieve interstitial bladder inflammation. Main toxicity of DMSO: It is permeable to human skin and irritating to the eyes. DMSO has a certain toxic effect. It interacts with protein hydrophobic groups, leading to protein denaturation, and has vascular toxicity and hepatorenal toxicity. When it is used to avoid volatilization, it is necessary to prepare 1%-5% ammonia water for backup, and wash the skin…

DMSO is a natural chemical originally found in wood. Over the past 60 years, more than 40,000 articles have been published on this type of DMSO, but the public is not aware of the application of DMSO in medicine and health. Medicine and health refuse to advertise, so unlike ordinary consumer goods, people can be informed about them through advertising. Even in the United States, even complementary foods placed on the open shelves of supermarkets cannot be advertised to spread relevant knowledge. DMSO, approved by the US FDA in 1974, is still only used by a small number of experts and practitioners of alternative medicine and natural medicine in the health and medical fields. DMSO has solution and permeability to many drugs, and it also has anti-inflammatory and analgesic effects. DMSO can promote blood circulation and wound healing, and has diuretic and antistatic effects. It can increase drug absorption and…

Transition metal halides such as chromium chloride, manganese chloride and potassium chloride, sodium chloride and other halides have a certain solubility in DMSO, so they can be used in organic electrochemistry. Dimethyl sulfoxide is widely used as a solvent and reaction reagent, especially as a processing solvent and drawing solvent in acrylonitrile polymerization, as a solvent for polyurethane synthesis and drawing, as a solvent for polyamide, polyimide and polysulfone resin synthesis, as well as a solvent for aromatics, butadiene extraction and synthesis of chlorofluoroaniline. DMSO is dimethyl sulfoxide and has a wide range of uses. Used as a solvent for acetylene, aromatics, sulfur dioxide and other gases and as a spinning solvent for acrylic fibers. It is a very important aprotic polar solvent soluble in both water and organic solvents. It is highly permeable to the skin and helps the drug penetrate into the human body. It can also be…

IntroduceDMSO, or dimethyl sulfoxide, is a commonly used solvent. It is a colorless transparent liquid with no odor or slight sulfur odor. DMSO is widely used in medicine, chemistry, biology and industry. Its chemical formula is (CH3) 2SO and its molecular weight is 78.13g/mol. NatureDMSO is liquid at room temperature and can be miscible with most organic and inorganic substances. It can be used to dissolve natural or synthetic compounds that are not easily soluble in conventional solvents. DMSO is a polar solvent, so it is commonly used to dissolve compounds with polar functional groups. It also has good solubility and diffusivity and can easily penetrate biofilms and skin, so it is also widely used in pharmaceutical therapies and skin care. ApplicationDMSO is widely used in a variety of fields, including biomedicine, drug research, cell culture, chemical synthesis, glass products, and digital printing. It is used in the medical field…

dmso is dimethyl sulfoxide, a sulfur-containing organic compound, at room temperature is colorless odorless transparent liquid, is a hygroscopic flammable liquid. Dimethyl sulfoxide has high polarity, high boiling point, good thermal stability, aprotic, miscible with water characteristics, can dissolve in ethanol, propanol, benzene and chloroform and other most organic matter, known as a universal solvent. Why “Universal” solvent “universal”Dimethyl sulfoxide (DMSO) is a hydrogen bond breaker. It is a sulfur-containing organic compound, colorless odorless transparent liquid at room temperature, is a kind of hypersonic flammable liquid, with high polarity, high boiling point, good thermal stability, aprotic, miscible with water characteristics, can dissolve in ethanol, propanol, benzene and chloroform and other most organic matter, known as “universal” solvent.How “Universal” solvent “Universal”● Widely used in oil processingThe freezing point of pure dimethyl sulfoxide is 18.45 degrees Celsius, and the dimethyl sulfoxide with 40% water is not frozen at minus 60 degrees Celsius,…

DMSO is a natural chemical originally found in wood. Over the past 60 years, more than 40,000 articles have been published on this type of DMSO, but the public is not aware of the application of DMSO in medicine and health. Medicine and health refuse to advertise, so unlike ordinary consumer goods, people can be informed about them through advertising. Even in the United States, even complementary foods placed on the open shelves of supermarkets cannot be advertised to spread relevant knowledge. DMSO, approved by the US FDA in 1974, is still only used by a small number of experts and practitioners of alternative medicine and natural medicine in the health and medical fields.DMSO has solution and permeability to many drugs, and it also has anti-inflammatory and analgesic effects. DMSO can promote blood circulation and wound healing, and has diuretic and antistatic effects. It can increase drug absorption and improve…

DMSO(Dimethylsulfoxide) was called a “miracle drug” when it was first discovered because of its widespread use, and then restricted by the FDA. How toxic are solvents that are widely disseminated, and how do we use them in our experiments? Today we will reveal the correct use of DMSO, the “universal solvent”, in cell and animal experiments. Introduction to DMSO Dimethylsulfoxide (DMSO) is a sulfur-containing organic compound whose structure is shown below. Physical properties: colorless odorless transparent liquid at room temperature, with strong hygroscopic, freezing point of 18.55℃, density and water close to 1.100g/mL; Chemical properties: The molecular formula is (CH3) 2SO, because the structure has a hydrophilic thionyl group and two hydrophobic methyl groups, it can be miscible with aqueous solution and most organic solvents except petroleum ether; It can dissolve about 80% of the compounds, and most of the water-soluble compounds and fat-soluble compounds can be dissolved by it,…