Tetrahydrofuran product presentation

Product name:Tetrahydrofuran
Abbreviation:THF
Cas No.:109-99-9
Molecular formula:C4H8O
Molecular weight:72.10570
Tetrahydrofuran chemical structural formula:

Density:0.9±0.1 g/cm3
Boiling point:66 ºC
Melting point:108.4 ºC
Point of flammability:-21 ºC

All the test performed according to the spec as follows:

Tetrahydrofuran is introduced
Tetrahydrofuran (THF) is a kind of heterocyclic organic compound, and also a cyclic ether. It is a colorless liquid with low viscosity and miscible with water at room temperature and pressure. It is a medium polar aprotic solvent often used in chemical reaction and extraction. Tetrahydrofuran is often used as an ether solvent with a higher boiling point in the laboratory, and its properties and uses are similar to ether, but its properties are often better. Under anhydrous conditions, ether is an excellent solvent for many less demanding reactions, but over a larger temperature range, tetrahydrofuran is a more reliable ligand and plays a role in fine-tuning the properties of the mixed solvent in many fine chemical reactions.
Tetrahydrofuran is an important organic chemical and fine chemical raw material, widely used as a resin solvent for tape coating, PVC surface coating, cellophane coating, plastic printing ink, thermoplastic polyurethane coating, involving Grinia reagent, aluminum hydride and boron hydride, alkyl alkali metal compounds and aryl alkali metal compounds and other chemical reactions. Polytetrahydrofuran (PTMEG), natural gas flavoring agent and other chemical intermediates are produced by polymerization.

Tetrahydrofuran can cause water loss into the skin, and can dissolve latex, so wear nitrile or neoprene gloves when using. The biggest safety hazard of tetrahydrofuran is the slow formation of highly explosive organic peroxides when exposed to air. In order to reduce this risk, 2, 6-di-tert-butyl-p-cresol (BHT) is usually added to commercially available tetrahydrofurans to inhibit the production of organic peroxides. At the same time, tetrahydrofuran should not be dried because organic peroxides will be enriched in the distillation residue.
Used as solvent and raw material for organic synthesis
It is used as a medium polarity aprotic solvent in chemical reactions and extraction. Tetrahydrofuran is a colorless, low-viscosity liquid with an odor similar to ether. At room temperature, tetrahydrofuran and water can be partially miscible, and some illegal reagent vendors use this to make huge profits on tetrahydrofuran reagents mixed with water. Tetrahydrofuran tends to become peroxide when stored. Therefore, commercial tetrahydrofurans often use BHT, 2, 6-di-tert-butyl-p-cresol, to prevent oxidation. Tetrahydrofuran can be stored in a dark place in a sealed bottle with sodium hydroxide.
Colorless transparent liquid. Smells of ether. It is an important organic chemical and fine chemical raw material, widely used in resin solvents (tape coating, PVC surface coating, cleaning PVC reactor, removing PVC film, cellophane coating, plastic printing ink, thermoplastic polyurethane coating); Reaction solvents (form reagents, alkyl alkali and aryl alkali metal compounds, aluminium and boron hydrides, steroidal compounds and macromolecular organic polymers); Chemical intermediates (polymerization to produce PTMEG, natural gas flavoring agent); Chromatographic solvent (gel permeation chromatography).

Application of tetrahydrofuran
Tetrahydrofuran, as a common solvent, is widely used in organic chemistry, biochemistry, medical chemistry and other fields. It can be used to catalyze esterification reaction, addition reaction, nucleophilic substitution reaction, oxidation reaction, reduction reaction and other catalysts and solvent organic synthesis reactions. In addition, tetrahydrofuran is also widely used in drug synthesis, cosmetics manufacturing, dye synthesis and other fields. It is also widely used in the preparation of drugs, extraction and separation of drugs, quality control drugs and other medical fields.
Properties of tetrahydrofuran
Tetrahydrofuran has the characteristics of low toxicity, low boiling point and good fluidity.
Tetrahydrofuran is a relatively strong polar solvent that can dissolve a variety of organic and inorganic substances. Due to its strong polarity, its dielectric constant is also relatively large, with a dielectric constant of 7.6. Tetrahydrofuran has a boiling point of 120℃ and a melting point of -136℃. The steam is low and is not easily volatilized in the air. The chemical properties of tetrahydrofuran are relatively stable and not easy to oxidize or reduce. However, ring-opening reaction is easy to occur under acid catalysis, and the epoxide group will be attacked by water or alcohol molecules under acid catalysis, thus forming corresponding ring-opening products.

Storage condition
Storage precautions Commodities are usually supplied with stabilizers. Store in a cool, ventilated warehouse. Keep away from fire and heat. The storage temperature should not exceed 29℃. The package should be sealed and not in contact with air. It should be stored separately from oxidizers, acids, bases, etc., and should not be mixed. Explosion-proof lighting and ventilation facilities are adopted. Do not use mechanical equipment and tools that are prone to spark. The storage area should be equipped with leak emergency treatment equipment and suitable containment materials.
stability
1. Colorless transparent liquid with an ether-like odor. It is miscible with water. The azeotrope with water can dissolve alkaloids such as cellulose acetate and caffeine, and the solubility is better than that of tetrahydrofuran alone. General organic solvents such as ethanol, ether, aliphatic hydrocarbons, aromatic hydrocarbons, chlorinated hydrocarbons, etc. can be well dissolved in tetrahydrofuran. In the air, it is easy to combine with oxidation to form explosive peroxide. It is not corrosive to metal and has an corrosive effect on many plastics and rubber. Due to the low boiling point and flash point, it is easy to catch fire at room temperature. When stored, the oxygen energy in the air reacts with tetrahydrofuran to form an explosive peroxide. Peroxides form more easily in the presence of light and no water. Therefore, 0.05%~1% of hydroquinone, resorcinol, p-cresol or ferrite are often added as antioxidants to inhibit the formation of peroxide. This product is low toxicity, operators should wear protective equipment.
2. Chemical properties: Explosive peroxides are generated in the air due to autoxidation. Succinic acid is produced when oxidized with nitric acid. Under the catalysis of alumina, pyrrolidine was obtained by reaction with ammonia at 300~400℃. Thiophene was obtained by reaction with hydrogen sulfide at 400℃. In the presence of zinc chloride, by the action of acid or acyl chloride, it is easy to open the ring into 1, 4-butanediol, 1, 4-dihalide. Under the influence of light, 2, 3-dichlorotetrahydrofuran is chlorinated at room temperature. The second chlorine atom is very reactive and can be directly replaced by alkoxy, acetic, or the alkyl group of Grignard’s reagent. Using acid phosphate as catalyst, tetrahydrofuran was dehydrated to produce butadiene at 270℃. When heated, tetrahydrofuran reacts with hydrogen chloride gas to rearrange into 4-chlorobutanol. In the presence of aluminum trichloride, tetrahydrofuran reacts with lithium aluminum hydride to quantitatively produce butanol.
3. Stability Stability
4. Forbidden compounds acids, bases, strong oxidants, oxygen
5. Avoid exposure to the conditions of light and air
6. Polymerization harms polymerization