pvp solution

What solvent does pvp dissolve in
Water, methanol, ethanol, propylene glycol, glycerin, organic acids and their esters, acetone, trichloromethane, etc. pvp is the abbreviation of polyethylpyrrolidone,

pvp is a non-toxic water-soluble polymer compound, has a good film formation, the average molecular weight of the number of PVP used in medicine in 10,000-

40,000. pvp can not only be miscible with water, but also dissolve in many alcohols, carboxylic acids, amines, halogenated hydrocarbons and other organic

solvents.

Solubility and solution properties of PVP
The solubility of a substance in different solvents is closely related to its structure. The molecular groups of PVP have both hydrophilic groups and oleophilic groups, so it can have affinity with many solvent molecules, so that it can be miscible with water, and can be dissolved in many alcohols, carboxylic acids, amines,halogenated hydrocarbons and other organic solvents. The solubility of PVP in water is limited only by the viscosity of the solution formed after dissolution, andorganic solvents in which PVP has a solubility of more than 10% at room temperature are:

Alcohol: methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, isobutanol, amyl alcohol, cyclohexanol, ethylene glycol, propylene glycol, butanediol,

glycerol
Ether: methyl butyl ether, crown ether
Alcohol ethers: ethylene glycol ether, diethylene glycol, triethylene glycol, 1, 6-hexadiol, polyethylene glycol 200, polyethylene glycol 400, sulfur ether Carboxylic acids: formic acid, acetic acid, propionic acid, acrylic acid

Lactones: gamma-butyrolactonesEsters: ethyl lactate, vinyl acetateKetones: methyl cyclohexanone, cyclohexanone (hot)

Halogenated hydrocarbons: dichloromethane, chloroform, 1, 2-dichloroethane
Amines: propylamine, n-butylamine, ethylenediamine, cyclohexylamine, aniline, pyridine, ethanolamine, diethanolamine, triethanolamine, 2-amino-2-

methylpropanol

Lactamides: 2-pyrrolidone, N-methylpyrrolidone, N-vinylpyrrolidone, N-ethylpyrrolidone
Others: Nitromethane, nitroethane.

Organic solvents that can dissolve PVP at room temperature, but the solubility is less than 1% are:

Hydrocarbons: benzene, toluene, xylene, petroleum ether, pentane, hexane, cyclohexane, heptane, solvent oil, kerosene, mineral oil, methyl cyclohexaneEthers: diethyl ether, dimethyl ether, methyl vinyl ether, isobutyl vinyl ether, tetrahydrofuran, polyethylene glycol 600, ethyl vinyl etherHalogenated hydrocarbons: carbon tetrachloride, chlorobenzene
Ketones: acetone, 2-butanone, cyclohexanone
Esters: ethyl acetate, isobutyl acetate.

The general rule can be roughly drawn from the dissolution of PVP in organic dissolution listed above: PVP has better solubility in organic solvents with strong

polarity, but is less soluble in weak polar or non-polar organic solvents.
The molecular weight of PVP also has a certain influence on the solubility. The solubility of PVP K15, K30 and K60 in water, ethanol and hexane is shown in Table

6.1.
Table 6.1 Solubility of PVP with different molecular weights in different solvents (mg/ml)

It can be seen from the data in the table that the solubility of PVP in water or polar organic solvents is much greater than that in weak polar or non-polar organic solvents. In organic solvents with strong polarity, the solubility of PVP decreases with the increase of molecular weight. At low molecular weight, the solubility does not change significantly with the increase of molecular weight, but with the increase of molecular weight, the solubility of PVP in polar solvents has a significant impact. However, the solubility of PVP in non-polar solvent (cyclohexane) is very small, and the change of molecular weight has no significant effect on its solubility.
The dissolution of PVP in some mixed solvent systems is of great significance to investigate the dissolution of PVP and its application.pvp solution common problems

Is pvp solution a real solution?
Depending on which molecular weight PVP, low molecular weight such as K9 and K15 is easily soluble in cold water and the molecular particle size is only a few nanometres is the true solution form, K30, K90 or K120 and other molecular weight is very large dissolved in cold water after a similar PVA gel state is not a true solution. The dissolution of PVP was similar to the curve of PEG with molecular weight from small to large.

pvp solution is colorless or colored
It’s colorless.
PVP is odorless, tasteless white powder or transparent solution, with excellent solubility, low toxicity, film formation, complexation, surface activity and chemical stability, soluble in water, containing chlorine solvents, ethanol, amines, nitroalkanes and low molecular fatty acids, with most inorganic salts and a variety of resins soluble, insoluble in acetone, ether.
pvp can also be combined with iodine, POvidone iodine solution, also known as iodophor or PVP iodine, the dosage form is reddish-brown liquid, can dissolve protein genes through oxides to achieve the purpose of disinfection and sterilization, POvidone iodine solution is a highly efficient and low toxic bactericidal drug.

Rheological properties of solution
Water and methanol are the best solvents for polyvinylpyrrolidone (PVP). The pH value has little effect on the viscosity of PVP aqueous solution. For example, at 25℃, the viscosity of aqueous solution with a mass fraction of 5% PVPK-30 in the range of 0.1 ~ 10 is 2.Chemicalbook3 ~ 2.4mPa·s. In concentrated hydrochloric acid, it is 4.96mPa·s. The influence of temperature on the viscosity of PVP solution is not obvious. Uncrosslinked PVP solutions have no special thixotropy except at very high concentrations and show very short relaxation times.

How long can PVP solution be preserved without deterioration?
Pure PVP aqueous solutions are also stable under normal conditions, but will discolor or hydrolyze under prolonged heating, storage, or acidic conditions.If aqueous solutions are not sterilized, they may be contaminated by microorganisms if they are to be stored for a longer period of time. Bacteriostatic agents such as sodium benzoate, potassium sorbate and sodium propionate should be added as appropriate.

How to easily distinguish PVP(polyvinylpyrrolidone) solution from water?Drop a drop on the hot plate, the white solid after the water evaporates is the PVP solution. pvp solution has viscosity.