polyvinylpyrrolidone solubility

Polyvinylpyrrolidone (PVP) is extremely soluble and can be dissolved in a variety of solvents. Specifically, PVP is soluble in water, chlorine-containing solvents, ethanol, amines, nitroalkanes, and low molecular fat acids. In addition, it has a good compatibility with most inorganic salts and a variety of resins. However, PVP is insoluble in a few solvents such as acetone and ether. This extensive solubility and compatibility gives PVP a unique advantage in a variety of applications. 12

Water solubility: PVP is highly soluble in water, which is one of its most important solubility properties.
Organic solvent solubility: In addition to water, PVP can also be dissolved in halogenated hydrocarbon solvents, alcohols, amines, nitroalkanes and low molecular fatty acids and other organic solvents.
Insoluble: In contrast, PVP is insoluble in a few solvents such as acetone, ether, turpentine, aliphatic hydrocarbons and alicyclic hydrocarbons.
These physical and chemical properties make PVYrrolidone widely used in many fields such as industry, medicine and food, including but not limited to as film forming agents, stabilizers, thickeners and drug carriers.

Water-soluble polyamide
Polyvinylpyrrolidone (PVP) is a water-soluble polyamide. Commercially available PVP is divided into four viscosity grades according to the FikentscherK value: K-15, K-30, K-60, K-90, and their relative molecular weights are 10,000 and 40,000, 160,000, and 360,000, respectively. K value or relative molecular mass is one of the important factors that determine various properties of PVP. Polyvinylpyrrolidone (PVP) is soluble in water, chlorinated solvents, ethanol, amines, nitroalkanes and low molecular fatty acids, and is soluble with most inorganic salts and a variety of resins; Insoluble in acetone, ether, etc. Polyvinylpyrrolidone (PVP) used in the matrix of dropping pills is odorless, tasteless, white to yellowish waxy solid with a relative density of 1.062 and pH of 5% aqueous solution ranging from 3 to 7. Polyvinylpyrrolidone is hygroscopic. Good thermal stability, soluble in a variety of organic solvents, high melting point. Adding some natural or synthetic polymers or organic compounds can effectively adjust the humidity and softness of PVP. Polyvinylpyrrolidone is not susceptible to chemical reaction, and dry PVP is very stable when stored under normal conditions. PVP has excellent physiological inertia and biocompatibility, no irritation to skin and eyes, no allergic reaction, non-toxic.
Due to hydrogen bonding or complexation, the viscosity of polyvinyl-chemicalbook pyrrolidone (PVP) increases, which inhibits the formation and growth of drug nucleation and makes the drug into an amorphous state. Polyvinylpyrrolidone (PVP) based dropping pills can improve the dissolution and bioavailability of insoluble drugs. In general, the greater the amount of PVP, the greater the dissolution and solubility of the drug in the medium. Susana et al. studied the dissolution of PVP(k30) solid dispersions of the slightly soluble drug albendazole. With the increase of the dosage of PVP(k30), the dissolution speed and dissolution efficiency of the drug in the solid dispersion increased. Teresa et al. studied the dissolution of PVP solid dispersion of flunarizine, an insoluble drug, and found that the higher the content of PVP, the more significant the dissolution increase. IR showed that flunarizine had no chemical effect on PVP. However, there are exceptions, some drugs and PVP in a certain proportion of the dissolution effect of the best. Tantishaiyakul et al. found that when the ratio of piroxicam to PVP was 1:5 and 1:6, the dissolution of the solid dispersion was the largest, which was 40 times higher than that of a single drug within 5 minutes.
Polyvinylpyrrolidone (PVP) can also be dissolved in other matrix of melted dropping pills, such as polyethylene glycol (PEG), polyoxyethylene monostearate (S-40), poloxamer, stearic acid, glycerol monostearate, etc., to make a composite matrix.
Chemical property
A crosslinked homopolymer of pure vinylpyrrolidone. A readily flowing white or nearly white powder with definite hygroscopicity. It smells slightly. It is easily insoluble in water and all common solvents such as ethanol and ether. However, polyvinylpyrrolidone (PVP) has the ability to severely bond with a variety of substances (such as various pigments that cause wine and other beverages to discolor). And because of its insolubility, it is easy to be removed after filtration.