Polyvinylpyrrolidone K90

Product description

Polyvinylpyrrolidone (PVP) is a non-ionic polymer that is commercially available in several viscosity levels, from low to high molecular weight. These classifications, combined with their solubility in aqueous/organic solvent systems, non-toxic characteristics, and stability against acids, salts, and heat, give PVP great flexibility in application. Industrial applications of PVP include, for example, being used as an adhesive to improve strength and thickness; Increase strength in paper production; Used as resin coating; Modified dyes in synthetic fibers; It is also commonly used in inks, imaging, lithography, detergents and soaps, textiles, pottery, electricity, metallurgy, and as a polymer additive. Due to its excellent adhesion, film forming, dispersion and thickening properties, PVP is also widely used in the pharmaceutical industry.

PVP is classified according to its average molecular weight size, which is usually marked by the K value, and different K values represent different average molecular weight ranges of PVP. The K value is actually the characteristic value related to the relative viscosity of PVP aqueous solution, and the viscosity is the physical value related to the molecular weight of polymer, so the average molecular weight of PVP can be characterized by K value. Generally speaking, the greater the K value, the greater the viscosity.

This product is Polyvinylpyrrolidone K90 (Polyvinylpyrrolidone K90), referred to as PVP-90, with an average molecular weight of 1,300,000.

Product characteristics

1) CAS NO: 9003-39-8

2) Synonymous name: Polyvinylpyrrolidone K90; Polyvidone; Povidone; Povidone; Polyn-vinylbutylactam;

3) Linear molecular formula: (C6H9NO)n

4) Average molecular weight: 1,300,000

5) K value: K88-96

6) Appearance: white to light yellow powder

7) Solubility: easily soluble in water, alcohol, amine and halogenated hydrocarbons; Insoluble in acetone, ether, etc.

Preservation and transportation methods

Storage: Store dry at room temperature for at least 3 years.

Transportation: room temperature transportation.

Matters needing attention

For your safety and health, please wear a lab coat and disposable gloves.

Polyvinylpyrrolidone (PVP) is a water-soluble polymer with good biostability, chemical stability, low toxicity and good biocompatibility. Therefore, it is of great benefit in various applications such as cosmetics, tissue engineering and biomedical engineering.
The specific application of polyvinylpyrrolidone in various industries
1. Adhesive for oral solid preparation
PVP is soluble in water and some commonly used organic solvents, making it suitable for use in many situations. First of all, in the drug sensitive to humidity and heat, the use of PVP ethanol solution as a binder can eliminate the influence of water and heat, and for hydrophobic drugs, its aqueous solution can be uniformly wetted, and the surface of drug particles can be hydrophilic, which is conducive to increasing the dissolution of drugs. In addition,PVP as an adhesive can be added with dry powder, wetting granulating with appropriate solvent or direct pressing of dry adhesive can improve the phenomenon of hydrophobic drug stripping. K30 and K25 are commonly used, and the amount of PVPK30 is generally 2%-5%.
In the use of effervescent agents,PVP is an ideal adhesive, because effervescent agents require strict control of water content, using PVP ethanol solution as a binder can solve this problem. The effervescent tablets made by this method have good obviousness, rapid dissolution and strong foaming. With about 5%-10% PVP solution as binder can also be used for fluidized bed spray drying granulation.
2, used in oral liquid preparations to thicken and viscose
PVP has a long history as a thickening agent in oral liquid preparations and has a wide range of applications, such as its emulsion and suspension PVPK-90 can be used as a good thickening stabilizer, and the polymer is adsorbated on the surface of a single colloidal ion to form a thin molecular layer to prevent its coalescence.
3, used as a solid dispersion carrier
To improve the absorption of insoluble drugs in vivo has always been a hot topic, to achieve this purpose, consider improving its solubility and dissolution rate, solid dispersion is the insoluble drugs in a molecule, colloidal, microcrystalline or amorphous form dispersed in a water-soluble material, can significantly improve the dissolution rate and more absorption. PVP is a common carrier of vegetation solid dispersion.
PVP is better as a solid dispersion carrier of carvedilol. PEG-6000 and PVP are commonly used solid dispersion carriers, which basically do not interfere with the determination of main drugs. After carvedilol was treated with solid dispersion technology, the dissolution rate in vitro and bioavailability in vivo were significantly increased, which provided an effective way for carvedilol to be prepared into highly effective preparations.
4, used as film coating material
Usually the standard PVP can be used as a medicinal film forming material or combined with other film materials because of its ideal flexibility. Practice has proved that PVP can be used in the film coating process of both water and organic solvent systems, and its coating advantages: it can improve the adhesion ability of the film to the surface, improve the dispersion of color lake or dye, can be used as a film plasticizer, and can change the disintegration time of the film based on hydrophobic materials. The commonly used concentration of coating is 0.5%– 5%. At present, PVP/VA series products are specially used as film forming materials, which are copolymers of VP(vinylpyrinolanone) and VA(vinyl acetate).
5, used in slow-release preparations
PVP can be used as adhesive, blocking agent, osmotic enhancer and so on. Ye Linlin et al. [8] developed single-chamber single-layer nifedipine oral osmotic pump tablets, optimized the formula and preparation parameters of nifedipine oral osmotic pump tablets, and determined the core formula, in which the content of PVP as an osmotic aid was 7.08%. The results showed that the release of nifedipine osmotic pump tablets prepared by the authors was in good agreement with the characteristics of zero-order release of osmotic pump tablets.
6, PVPK series is one of the excellent medicinal synthetic new excipients, mainly used as a binder for tablets, pills and granules, co-solvent for injections, flow aid for capsules, co-precipitation agent for refractory drugs, detoxification of eye drugs and lubricants.
7, polyvinylpyrrolidone /PVP-K series products
Chemical name: polyvinylpyrrolidone
CTFA Name :POLYVINYLPYRROLIDONE(PVP)
Properties: Powder or aqueous solution,PVP is easily soluble in water, alcohol, amine and halogenated hydrocarbons, insoluble in acetone, ether and so on. It has excellent solubility, biological compatibility, physiological inertness, film forming, membrane protection ability and the ability to compound with a variety of organic and inorganic compounds, and is stable to acid, salt and heat, so it has a wide range of uses.
Application of PVP in industrial and high-tech fields :PVP can be used as surface coating agent, dispersant, thickener and adhesive in pigment, printing ink, textile, printing and dyeing, color picture tube. PVP can improve the bond performance of binder to metal, glass, plastic and other materials, and PVP in the separation film, medical polymer materials, light solid resin, light solid coating, optical fiber, laser disc and other emerging high-tech fields are also increasingly widely used
8, the application of medicinal grade PVP(POvidone)
Povidone is widely used in medicine and is one of the three new pharmaceutical excipients advocated internationally. The most widely used adhesives are tablets and granules. PVP can also be used as a flow aid for capsules, a detoxifying agent and lubricant for eye drugs, a co-solvent for injections, a dispersant for liquid preparations, and a stabilizer for enzymes and heat-sensitive drugs. Povidone can also synthesize PVP-I disinfectant with iodine. In contact lenses,PVP is used as a component of contact lenses to increase their hydrophilicity. PVP can also be used as a cryogenic preservative in medicine.