NMP(N-methylpyrrolidone)-MSDS

N-methylpyrrolidone

Material Safety Data Sheet Material safety data sheet

Part I Chemicals
Chinese name of chemical: N-methylpyrrolidone
Chemical name or trade name: NMP

Part II Composition/composition information

Chemical name: N-methylpyrrolidone
Harmful ingredients: N-methylpyrrolidone concentration: ≧99.9%
CAS No. : (EINECS number: 212-828-1)
The third part is danger summary

Risk category: No data available
Route of invasion: contact (eyes and skin), ingestion (inhalation or ingestion)
Health hazard: Eye: Too much contact can irritate the eyes. Skin: Prolonged or frequent contact can cause dermatitis, such as blisters, tears, edema, and/or redness of the skin. Ingestion: May cause dizziness, nausea, and/or irritation. Inhalation: Inhalation of high concentrations of this product can cause headache, dizziness, nervous confusion and/or nausea. Long-term inhalation: No life-shortening toxicity or carcinogenic effect was observed in rat tests.
Environmental hazards: LC50 (light blue edible large sunfish) 832 mg/l, 22℃ LC50 (Pathead Minnow) 1072 mg/l, 22℃ LC50 (salmonfish) 3048 mg/l, 22℃
Ignition hazard: This product is flammable, flash point is 99℃, ignition temperature is 346℃
Part IV first aid measures

Skin contact: Use alkaline soap to immediately rinse the contact area under warm running water. If irritation persists, seek medical attention. The spilled clothes should be washed before wearing.

Eye contact:
Immediately open the upper and lower eyelids and rinse generously with water for at least 15 minutes. If irritation persists, seek medical attention immediately.
Inhalation: Remove from the contact area to a place with fresh air and allow the injured person to rest. If you still feel unwell, seek medical attention immediately.
Ingestion: Make the victim drink a lot of water or milk to dilute the chemical and try to make him vomit. Then seek immediate medical attention.
Notice to doctors: —
Part V fire control measures

Dangerous characteristics: flammable, flash point is 99℃, ignition temperature is 346℃
Harmful combustion products: carbon nitrogen oxides
Fire extinguishing method and extinguishing agent: Fire extinguishing procedure: 1. Isolate all personnel from the danger area. 2. Firefighters should wear appropriate firefighting clothing, as they usually do to fight fires. Applicable fire extinguishing agent: water, foam, chemical dry powder and carbon dioxide.
Fire precautions: —
The sixth part leakage emergency treatment

Emergency treatment: Individual should pay attention to: 1. Before the contaminated area has not been completely cleaned up, restrict personnel to approach the area. 2. Wear appropriate personal protective equipment. Environmental precautions: Avoid spilling into sewers, waterways or low-lying areas.
Elimination method: For small amounts of spills, blot or wipe with absorbable materials, and then place in a chemical waste container. For large amounts of spills, build a barrier or enclose the liquid and collect it in a container. Do not discharge into sewers or waterways. Then wipe the sprinkling area with a waste rag.
Part VII operation, disposal and storage

Operation precautions: Only use in a well-ventilated place or open air, do not inhale steam, try to operate in the downwind. Avoid eye, skin or clothing contact with this product, pay attention to wear appropriate protective equipment. Avoid leaks, spills or spills. Avoid careless operation or dripping and prevent physical damage.
Storage precautions: Store in a cool, dark and well-ventilated place. Store in sealed container. Keep away from heat sources, steam pipes, or direct sunlight. Avoid oxidizing materials, organic peroxides or flammable materials.
Part 8 Contact Control/Personal Protection

Maximum permissible concentration: Occupational exposure limit: ACGIH TLV (TWA) is not formulated
Monitoring method: No data
Engineering control: No data available
Respiratory protection: No data available
Eye protection: No data available
Body protection: No data available
Hand protection: No data available
Other protection: It is recommended to use in the case of adequate ventilation
Part IX: Physical and chemical properties

Appearance and properties: colorless or light yellow liquid
pH value: meaningless
Melting point (℃) : -23℃ Relative density (water =1) : 1.027 (25℃/4℃)
Boiling point (℃) : 204 ℃ Relative vapor density (air =1) : No data available
Saturated vapor pressure (kPa) : — Heat of combustion (kJ/mol) : C
Critical temperature (℃) : — Critical pressure (MPa) : 3200 Pa (100℃)
Pair value of octanol/water partition coefficient: —
Flash point (℃) : 99 ℃ Explosion upper limit % (V/V) : 11.8%
Ignition temperature (℃) : 346℃ Lower explosive limit % (V/V) : 1.0%
Solubility: soluble in water, soluble in various organic solvents.
Other physical and chemical properties: flammable, slightly alkaline (amine) odor
Part X Stability and reactivity

Stability: Stable under conventional and intended storage or operating conditions. With air can form peroxide mixture.
Forbidden compounds: strong oxidant, strong base, strong acid
Conditions for avoiding contact: Avoid placing in heated containers. Avoid contact with strong oxidants, alkalis and acids.
Aggregation hazards: No data available
Decomposition products: carbon and nitrogen oxides can be generated during combustion.
Part XI Toxicological data

Acute toxicity: Oral: LD50 (rat) 7cc/kg LD50 (rat) 3914mg/kg LD50 (mouse) 5130 mg/kgLD50 (rabbit) 3500 mg/kg Skin: LD50 (rabbit) 8000 mg/kg Inhalation: At 20 ° C, the rats were exposed to large amounts of the substance or diffuse atmosphere, and no death was found after 8 hours.
Subacute and chronic toxicity:
Subacute toxicity: Oral: NMP-containing food is fed to mice, rats, and dogs at 1% concentration for 90 days. No toxic effect of NMP was found in the above animal experiments. Skin: NMP skin contact test was performed on rabbits at 0.4-0.8mg/kg daily for 20 days. No toxic effect of NMP was found in the above animal experiments. Inhalation: Rats were exposed to NMP aerosol vapor mixtures at concentrations of 0, 0.1, 0.5 and 1.0mg/l for 6 hours a day, 5 days a week for 4 weeks. Lethargic dyspnea and excessive mortality were found in rats at 1.0mg/l. Chronic toxicity: Rats were exposed to atmospheric concentrations of 0.04 or 0.4mg/L for 6 hours a day, 5 days a week for 2 years, and no life-shortening toxicity or carcinogenic effect was observed.
Irritation: Eye: Causes conjunctivitis. At atmospheric concentrations of 0.7vol.ppm, continuous exposure to NMP vapor for 30 minutes can cause severe eye irritation and/or headache. Skin: Easily absorbed through the skin, can cause edematous dermatitis. Prolonged or frequent contact with NMP fluids can cause severe dermatitis and exfoliation.
Sensitization: None
Mutagenicity: Negative on Ames test.
Teratogenicity By applying NMP to the skin of rats and conducting a deformity test, it was found that maternal toxicity at 750mg/kg and weight gain during pregnancy decreased. At the same time, fewer fetuses were observed per mother, and the proportion of resorption and skeletal abnormalities increased. At 75 or 237mg/kg, there are neither abnormal effects nor maternal effects.
Carcinogenicity: None
Other: Regenerative toxicity: Pregnant rats were exposed to an atmosphere containing NMP concentrations of 0.1 or 0.36mg/l every 6 hours for 6 days during a 15-day gestation. During the first 3 days of placement, there were no abnormal clinical symptoms or rates of pregnancy or embryo growth, except for occasional lethargy or irregular breathing observed in several rats. No non-abnormal development was detected in the vital organs and bones of the fetus.
Part XII ecological data

Ecotoxicity: LC50 (light blue edible large sunfish) 832 mg/l, LC50 (Pathead Minnow) 1072 mg/l at 22℃, LC50 (salmon) 3048 mg/l at 22℃
Biodegradability: BOD 1300 ppm (water soluble 0.1%)
Bioenrichment or bioaccumulation: None
Non-biodegradable: CODMn 340 ppm (water soluble 0.1%)
Other harmful effects: —
Part XIII Waste disposal

Physical properties of waste:  hazardous waste □ Industrial solid waste
Waste disposal method: 1. Incineration in a chemical incinerator with afterburner and scrubber. A. For a large amount of waste, it can be sprayed in a chemical incinerator.
b. For small amounts of waste, blot the material with a piece of cotton cloth and burn the cloth in a chemical incinerator. 2. Contaminated water shall be treated using the best available methods and then discharged into SWERES or aquatic environments.
Part XIV Transport information

Dangerous Goods Number: No information available
UN number: UN number is not applicable
Packing mark: No information available
Package type: No information available
Packing method: No information available
Shipping precautions: comply with all national regulations. When transporting, check the container for leaks and properly load it into the container.
Part XV Regulatory information

Regulatory Information: 1, domestic chemical safety management regulations information Hazardous chemicals safety Management Regulations (Decree No. 344 of The State Council of the People’s Republic of China) Chemical hazardous substances safety management Regulations implementation rules (Hualofa [1992] No. 677) Workplace safety use of chemicals provisions ([1996] Ministry of Labor 423 The classification and marking of commonly used hazardous chemicals (GB13690-92) are Class ** * flammable liquids with flash point