dimethyl sulfoxide preparation

Dimethyl sulfoxide, referred to as DMSO, is a colorless odorless flammable liquid with moisture absorption, extremely low toxicity, good thermal stability, can dissolve butyl water, ethyl yeast, acetone, ethyl energy, benzene and chloroform and other organic solvents, is a strong polarity of the emotional solvent.
Dimethyl sulfoxide is a widely used organic chemical product. In organic synthesis, it can be used as polymerization and condensation of acrylic fiber; Copolymerization of endolefin with other monomers, synthesis and spinning of polyurethane, synthesis of polyamide and polysulfone sulfone fat, solvent for spinning, esterification, carving and acetal chemistry of polyvinyl alcohol; In the pharmaceutical industry, it can be used as floxacin.

The preparation methods of dimethyl sulfoxide (DMSO) mainly include the following:

Methanol carbon disulfide method: methanol and carbon disulfide as raw materials, γ-Al2O3 as catalyst, the first synthesis of dimethyl sulfide, and then with nitrogen dioxide (or nitric acid) oxidation to dimethyl sulfoxide.
Hydrogen peroxide method: Using acetone as a buffer medium, dimethyl sulfide reacts with hydrogen peroxide. This method is expensive and not suitable for mass production.
Nitrogen dioxide process: methanol and hydrogen sulfide in the action of γ-alumina to produce dimethyl sulfide; Sulfuric acid reacts with sodium nitrite to form nitrogen dioxide; Dimethyl sulfide and nitrogen dioxide are oxidized in gas and liquid phase at 60-80℃ to produce crude dimethyl sulfoxide, or directly oxidized with oxygen to produce crude dimethyl sulfoxide, and then distilled under reduced pressure to produce dimethyl sulfoxide. This method is a relatively advanced production method.
Dimethyl sulfate process: dimethyl sulfate reacts with sodium sulfide to produce dimethyl sulfide; Sulfuric acid reacts with sodium nitrite to form nitrogen dioxide; Crude dimethyl sulfoxide was oxidized with nitrogen dioxide, and refined dimethyl sulfoxide was obtained after neutralization and distillation.
In addition, there is a method of producing dimethyl sulfoxide from dimethyl sulfide by anodizing. Each of these methods has its own characteristics and application scenarios, and the selection of the appropriate preparation method depends on the production cost, production scale and product purity requirements.
Dimethyl sulfoxide (DMSO) is an important organic synthetic solvent, widely used in drugs, pesticides, dyes, resins, polymers and other industries. The production process is mainly divided into three steps, the first is to synthesize dimethyl methanesulfonate, and then demethyl it to produce sodium methanesulfonate, and finally react with sulfur dioxide to produce DMSO.