Application areas of polyvinylpyrrolidone PVP

Chemical name: Crosslinked polyvinyl pyrrolidone CTFA Name: Crosslinked
Polyvinylpyrrolidone properties: white or nearly white, with hygroscopic easy to flow powder, odorless or slightly odorless, insoluble in water, alkali, acid and common organic solvents, with strong expansion performance and complex ability with many kinds of substances. Application: As a stabilizer for beer, liquor, grape juice and fruit juice and other drinks, to extend its storage period. In the pharmaceutical industry, it is mainly used as a disintegrating agent for tablets, and can also be used as a disintegrating agent and filler for pills, granules and hard capsules.

Drug property
​Nature:
1, general properties and solubility PVPP is white or slightly white powder supply, with a slight special smell, basically tasteless, insoluble in water and various organic solvents.
2. Hygroscopicity
The water absorption of PVPP increases with the increase of relative humidity.
3. The formation of small gel inhibits the penetration of water into tablets and slows down the disintegration rate of tablets. PVPP, in contrast to some other disintegrating agents, is insoluble and has no tendency to form gels at all.
4, coordination and solubilization PVPP and a variety of medicines and other substances can form complexes, the formation process is reversible, in the alkaline medium is not shaped
Agreed. It is more likely to form complexes with those aromatic compounds containing phenyl and/or carboxylic groups, and therefore, in the pharmaceutical industry, it can improve the solubility and bioavailability of medicines, improve the taste of perpyrexine, adsorb polyphenols and tannins from tinctures and herbs, and has the effect of combating diarrhea, gastritis, ulcers, esophageal hiatus cancer, etc.
5, good compatibilization PVPP and a variety of organic and inorganic pharmaceutical excipients and active ingredients, have very good compatibilization, solid drugs containing PVPP tablet disintegrators, can be easily produced using commonly used pill production technology, including direct tablet pressing, spray, dry and wet granulation. 6. Compressibility and bonding
PVPP has excellent fluidity and plastic deformation, so they have excellent bonding properties. This property gives good compressibility in spray, dry, and wet granulation. When PVPP tablet disintegrators are added to tablets, compared with commonly used starch, cellulose preparations and pectin compounds, the hardness and wear resistance of tablets are not affected, and the cap length of tablets is not reduced. PVPP can also be used effectively as a tablet disintegrator in direct compression tablets without the need for lubricants or adhesives.
7. Study on capillary activity and hydration capacity
Work has shown that PVPPS as tablet disintegrators have high capillary activity and hydration capacity due to their large specific surface area (average 1.25 m/g) and significant water absorption (high and rapid water absorption, up to more than 60%).
8, swelling and disintegration PVPP has high capillary activity, so it can quickly absorb water into the tablet. Because the internal pressure (swelling pressure) exceeds the strength of the tablet, the tablet dissolves in an instant. And because there are folded molecular chains between the crosslinks, when water or aqueous solutions penetrate, they are stretched by the sudden impact and forced to separate immediately. The expansion results in an increase in net volume (approximately twofold in 5 minutes), resulting in the immediate disintegration of tablets formulated with PVPP tablet disintegrators.