{"id":422,"date":"2023-12-20T15:21:39","date_gmt":"2023-12-20T07:21:39","guid":{"rendered":"https:\/\/www.yearnintl.com\/?p=422"},"modified":"2024-03-01T13:46:43","modified_gmt":"2024-03-01T05:46:43","slug":"universal-solvent-dmso","status":"publish","type":"post","link":"https:\/\/www.yearnintl.com\/ko\/problems\/universal-solvent-dmso\/","title":{"rendered":"\u201c\ub9cc\ub2a5\uc6a9\ub9e4\u201d \u2013DMSO"},"content":{"rendered":"

DMSO(\ub514\uba54\ud2f8\uc220\ud3ed\uc2dc\ub4dc)\ub294 \uad11\ubc94\uc704\ud558\uac8c \uc0ac\uc6a9\ub418\uae30 \ub54c\ubb38\uc5d0 \ucc98\uc74c \ubc1c\uacac\ub418\uc5c8\uc744 \ub54c \u201c\uae30\uc801\uc758 \uc57d\u201d\uc774\ub77c\uace0 \ubd88\ub838\uc9c0\ub9cc FDA\uc5d0 \uc758\ud574 \uc81c\ud55c\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ub110\ub9ac \ud37c\uc9c4 \uc6a9\ub9e4\ub294 \uc5bc\ub9c8\ub098 \ub3c5\uc131\uc774 \uc788\uc73c\uba70, \uc2e4\ud5d8\uc5d0\uc11c \uc774\ub97c \uc5b4\ub5bb\uac8c \uc0ac\uc6a9\ud569\ub2c8\uae4c? \uc624\ub298\uc740 \uc138\ud3ec \ubc0f \ub3d9\ubb3c \uc2e4\ud5d8\uc5d0\uc11c '\ub9cc\ub2a5\uc6a9\ub9e4'\uc778 DMSO\uc758 \uc62c\ubc14\ub978 \uc0ac\uc6a9\ubc95\uc744 \uacf5\uac1c\ud558\uaca0\uc2b5\ub2c8\ub2e4.<\/p>\n

DMSO \uc18c\uac1c<\/p>\n

\ub514\uba54\ud2f8\uc220\ud3ed\uc2dc\ub4dc(DMSO)\ub294 \ud669 \ud568\uc720 \uc720\uae30 \ud654\ud569\ubb3c\ub85c \uadf8 \uad6c\uc870\ub294 \uc544\ub798\uc640 \uac19\uc2b5\ub2c8\ub2e4.<\/p>\n

\ubb3c\ub9ac\uc801 \ud2b9\uc131: \uc2e4\uc628\uc5d0\uc11c \ubb34\uc0c9 \ubb34\ucde8\uc758 \ud22c\uba85\ud55c \uc561\uccb4, \ud761\uc2b5\uc131\uc774 \uac15\ud558\uace0 \uc5b4\ub294\uc810\uc774 18.55\u2103, \ubc00\ub3c4 \ubc0f \uc218\ubd84\uc774 1.100g\/mL\uc5d0 \uac00\uae5d\uc2b5\ub2c8\ub2e4.<\/p>\n

\ud654\ud559\uc801 \ud2b9\uc131: \ubd84\uc790\uc2dd\uc740 (CH3)2SO\uc785\ub2c8\ub2e4. \uad6c\uc870\uc5d0 \uce5c\uc218\uc131 \ud2f0\uc624\ub2d0 \uadf8\ub8f9\uacfc \ub450 \uac1c\uc758 \uc18c\uc218\uc131 \uba54\ud2f8 \uadf8\ub8f9\uc774 \uc788\uae30 \ub54c\ubb38\uc5d0 \uc218\uc6a9\uc561 \ubc0f \uc11d\uc720 \uc5d0\ud14c\ub974\ub97c \uc81c\uc678\ud55c \ub300\ubd80\ubd84\uc758 \uc720\uae30 \uc6a9\ub9e4\uc640 \uc11e\uc77c \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub294 \ud654\ud569\ubb3c\uc758 \uc57d 80%\ub97c \uc6a9\ud574\uc2dc\ud0ac \uc218 \uc788\uc73c\uba70, \ub300\ubd80\ubd84\uc758 \uc218\uc6a9\uc131 \ud654\ud569\ubb3c\uacfc \uc9c0\uc6a9\uc131 \ud654\ud569\ubb3c\uc744 \uc6a9\ud574\uc2dc\ud0ac \uc218 \uc788\uc73c\ubbc0\ub85c DMSO\ub294 \"\ub9cc\ub2a5 \uc6a9\ub9e4\"\ub77c\uace0\ub3c4 \uc54c\ub824\uc838 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

DMSO\uc758 \uc5ed\uc0ac<\/p>\n

DMSO\ub294 1866\ub144 \ub7ec\uc2dc\uc544 \uc758\uc0ac AlexanderM.Saytzeff\uc5d0 \uc758\ud574 \ubc1c\uacac\ub418\uc5c8\uc2b5\ub2c8\ub2e4. 1950\ub144\ub300 \uc601\uad6d \uacfc\ud559\uc790\ub4e4\uc740 DMSO\uac00 \uace8\uc218\uc640 \ud608\uc561 \uc138\ud3ec\ub97c \uc800\uc7a5\ud558\ub294 \ubd80\ub3d9\uc561\uc73c\ub85c \uc0ac\uc6a9\ub420 \uc218 \uc788\uc74c\uc744 \ubc1c\uacac\ud588\uc2b5\ub2c8\ub2e4. \ubaa9\uc7ac \ud384\ud504 \uc0b0\uc5c5\uc5d0\uc11c \ubc1c\uc0dd\ud558\ub294 \uc774 \ub3c5\ud2b9\ud55c \ubd80\uc0b0\ubb3c\uc740 \uc0b0\uc5c5\uc6a9 \uc6a9\uc81c \ubc0f \ud398\uc778\ud2b8 \ud76c\uc11d\uc81c\ub85c\ub3c4 \uc0ac\uc6a9\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uacfc\ud559\uc790\ub4e4\uc740 \ub9ce\uc740 \uc5f0\uad6c\ub97c \uc218\ud589\ud588\uc73c\uba70 \uadf8 \uacb0\uacfc DMSO\uac00 \uc2e0\uc18d\ud558\uac8c \ud1b5\uc99d\uc744 \uc644\ud654\ud558\uace0 \ub450\ud1b5\uc744 \ub05d\ub0b4\uba70 \uadfc\uc721 \uc5fc\uc88c \ubc0f \ud654\uc0c1\uc744 \uc2e0\uc18d\ud558\uac8c \ud68c\ubcf5 \ubc0f \ud68c\ubcf5\uc2dc\ud0ac \uc218 \uc788\uc74c\uc744 \ubcf4\uc5ec\uc90d\ub2c8\ub2e4.<\/p>\n

1963\ub144 FDA\ub294 DMSO\ub97c \uc778\uccb4 \uc2e4\ud5d8\uc6a9\uc73c\ub85c \uc2b9\uc778\ud588\uc73c\uba70, \uc77c\ubd80 \ub300\ud615 \uc81c\uc57d\ud68c\uc0ac\ub294 \ucd1d 2\uc5b5 5\ucc9c\ub9cc \ub2ec\ub7ec\ub97c \uc9c0\ucd9c\ud558\uace0 10\ub9cc \uba85 \uc774\uc0c1\uc744 \ub300\uc0c1\uc73c\ub85c \ud14c\uc2a4\ud2b8\ud558\ub294 \ub4f1 \uc804\ub840 \uc5c6\ub294 \uc218\uc758 \uc2e4\ud5d8\uc744 \uc218\ud589\ud588\uc73c\uba70, \uac01 \uc2e4\ud5d8 \uadf8\ub8f9\uc5d0\uc11c DMSO\uac00 \ub9e4\uc6b0 \uc548\uc804\ud558\uace0 \uc548\uc804\ud558\ub2e4\ub294 \uc0ac\uc2e4\uc774 \uc785\uc99d\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ud6a8\uacfc\uc801\uc778 \ubb3c\uc9c8. \uadf8\ub7ec\ub098 \uc81c\uc57d\ud68c\uc0ac\uc778 Merck\uc758 \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 DMSO\ub97c \ud22c\uc5ec\ubc1b\uc740 \uc77c\ubd80 \ub3d9\ubb3c\uc758 \ub208 \uc218\uc815\uccb4\uc5d0 \uc57d\uac04\uc758 \ud63c\ud0c1\ud55c \ubcc0\ud654\uac00 \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4. 1965\ub144 12\uc6d4 25\uc77c, \uba38\ud06c\uc758 \uc5f0\uad6c\uc5d0 \uae30\ucd08\ud558\uc5ec FDA\ub294 DMSO\uc758 \ubaa8\ub4e0 \uc778\uac04 \uc0ac\uc6a9\uc744 \uae08\uc9c0\ud588\uc2b5\ub2c8\ub2e4. \uc544\ub798 \uadf8\ub9bc\uc5d0\uc11c \uc54c \uc218 \uc788\ub4ef\uc774 1965\ub144 \uc774\ud6c4 \uacfc\ud559\uc790\ub4e4\uc740 DMSO\uc758 \ub3c5\uc131\uc5d0 \ub300\ud574 \uad11\ubc94\uc704\ud55c \uc5f0\uad6c\ub97c \uc9c4\ud589\ud588\uc73c\ub098 \uac74\uac15\ud55c \uc2e4\ud5d8\ub3d9\ubb3c\uacfc \uc778\uac04\uc5d0\uac8c\ub294 \uc2ec\uac01\ud55c \ub3c5\uc131 \ubd80\uc791\uc6a9\uc774 \uc788\ub294 \uac83\uc73c\ub85c \ubc1d\ud600\uc9c0\uc9c0 \uc54a\uc558\uc73c\ub098 \uc138\ud3ec\uc5d0\ub294 \uc0c1\ub300\uc801\uc73c\ub85c \ub3c5\uc131\uc774 \uc788\uc5b4\uc11c DMSO\ub294 FDA\uc5d0 \uc758\ud574 \ube44\ud2b9\uc218\uc801\uc774\uace0 \ub300\uccb4 \ubd88\uac00\ub2a5\ud55c \uacbd\uc6b0\uc5d0 \uc0ac\uc6a9\ub418\ub3c4\ub85d \uc81c\ud55c\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n

\"\u201cUniversal<\/p>\n

 <\/p>\n

DMSO \ub3c5\uc131<\/p>\n

1. DMSO\uc758 \uc138\ud3ec\ub3c5\uc131: < 0.1%(v\/v)\ub85c \uc81c\uc5b4\ud574\uc57c \ud568<\/p>\n

2008\ub144\uc5d0 QiWeidong et al. \ub2d8\uc758 \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 \ubc30\uc591\uc561\uc5d0 DMSO\uac00 0.1%-0.25%(v\/v)\ub85c \ud3ec\ud568\ub418\uc5b4 \uc788\uc744 \uacbd\uc6b0 24\uc2dc\uac04 \uc774\ub0b4\uc5d0 \uc950\uc758 dasyic \uc138\ud3ec\uc5d0 \uc190\uc0c1\uc774\ub098 \uc601\ud5a5\uc774 \uc5c6\uc5c8\uc9c0\ub9cc \ubc30\uc591\uc561\uc758 DMSO \ud568\ub7c9\uc774 0.5%\uc5d0 \ub3c4\ub2ec\ud558\uba74 \uc950\uc758 dasyic \uc138\ud3ec\uc5d0 \uc190\uc0c1\uc774\ub098 \uc601\ud5a5\uc774 \uc5c6\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4. -6%, dasyic \uc138\ud3ec\ub294 \uc190\uc0c1 \ubc0f \uc6a9\ub7c9 \uc758\uc874\uc801 \uc138\ud3ec \uc0ac\uba78\uc744 \ub098\ud0c0\ub0c8\uc2b5\ub2c8\ub2e4.<\/p>\n

2014\ub144\uc5d0 He Bing et al. 's \uc5f0\uad6c\uc5d0\uc11c\ub294 \uc138\ud3ec \ubc30\uc591 \ubc30\uc9c0 \ub0b4 \ub2e4\uc591\ud55c \u200b\u200b\ub18d\ub3c4\uc758 DMSO\uac00 \uc2dc\ud5d8\uad00 \ub0b4\uc5d0\uc11c \ubc30\uc591\ub41c \ud1a0\ub07c \uc5f0\uace8\uc138\ud3ec\uc758 \uc131\uc7a5\uc5d0 \ud2b9\uc815 \uc601\ud5a5\uc744 \ubbf8\uce58\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4. DMSO\uc758 \ub18d\ub3c4\uac00 2.0%(v\/v)\uc77c \ub54c \uc5f0\uace8\uc138\ud3ec\uc5d0 \ub300\ud55c \uac15\ud55c \uc5b5\uc81c\ud6a8\uacfc\ub97c \ub098\ud0c0\ub0c8\uc73c\ub098, 0.1%-1.0% \ub18d\ub3c4\ubc94\uc704\uc5d0\uc11c\ub294 \uc138\ud3ec\uc131\uc7a5\uc5d0 \uac70\uc758 \uc601\ud5a5\uc744 \ubbf8\uce58\uc9c0 \uc54a\uc558\ub2e4.<\/p>\n

2. DMSO\uc758 \ud6a8\uc18c \ub3c5\uc131: < 0.1%(v\/v)\ub85c \uc81c\uc5b4 \ud544\uc694<\/p>\n

2011\ub144 RamakrishnaNirogi et al. \uc778\uac04 \uac04 \ub9c8\uc774\ud06c\ub85c\uc19c\uc758 \uc778\ud050\ubca0\uc774\uc158 \uc2e4\ud5d8\uc5d0\uc11c \uc778\ud050\ubca0\uc774\uc158 \uc2dc\uc2a4\ud15c\uc758 0.1% \uc774\uc0c1\uc758 DMSO \ud568\ub7c9\uc774 \uc778\uac04 \uac04 \ub9c8\uc774\ud06c\ub85c\uc19c\uc5d0\uc11c CYP1A2\uc758 \ud65c\uc131\uc744 \uc5b5\uc81c\ud560 \uc218 \uc788\uc74c\uc744 \ubc1c\uacac\ud588\uc2b5\ub2c8\ub2e4. \uadf8\ub7ec\ub098 2% \ub18d\ub3c4\uc758 \uba54\ud0c4\uc62c\uc774\ub098 \uc544\uc138\ud1a0\ub2c8\ud2b8\ub9b4\uc740 \ud6a8\uc18c \ud65c\uc131\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4.<\/p>\n

2003\ub144 MasuhiroNISHIMURA et al. \ud654\ud569\ubb3c\uc774 \uc778\uac04 \uac04 \uc138\ud3ec\uc5d0 \ud22c\uc5ec\ub420 \ub54c \uac04 \uc138\ud3ec \ud558\uc704 \uc720\ud615 \uc2dc\ud1a0\ud06c\ub86c P450 \ud6a8\uc18c(CYP) \ub2e8\uacc4\uc758 \uc57d\ubb3c \ub300\uc0ac \ud6a8\uc18c\uc5d0\uc11c 0.1% \uc774\ud558 \uc218\uc900\uc758 DMSO \ub18d\ub3c4, \uc138\ud3ec \ud558\uc704 \uc720\ud615 \uae00\ub8e8\ucfe0\ub85c\ub2d0\uc758 2\ub2e8\uacc4 \uc57d\ubb3c \ub300\uc0ac \ud6a8\uc18c\ub97c \ubc1c\uacac\ud588\uc2b5\ub2c8\ub2e4. \ud2b8\ub79c\uc2a4\ud37c\ub77c\uc81c(UGT)\ubfd0\ub9cc \uc544\ub2c8\ub77c \uc8fc\uc694 \ub9c9\uad00\ud1b5 \uc218\uc1a1\uccb4\uc778 ABC \uc218\uc1a1\uccb4(ATPBingCasstteeTransporters\uc758 \ubc1c\ud604\ub7c9)\ub3c4 \ud6a8\uacfc\uac00 \uc5c6\uc5c8\uace0, \ub18d\ub3c4\uac00 \ub192\uc744\uc218\ub85d \ubc1c\ud604\uc774 \ubcc0\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc704\uc758 \ub3c5\uc131 \ub370\uc774\ud130\uc5d0\uc11c \ubcfc \uc218 \uc788\ub4ef\uc774 \ub2e4\ub978 \uc548\uc804\ud558\uace0 \ubb34\ub3c5\uc131\uc778 \uc6a9\ub9e4\uc640 \ube44\uad50\ud560 \ub54c DMSO\ub294 \ud2b9\uc815 \ub3c5\uc131\uc744 \uac00\uc9c0\uace0 \uc788\uc9c0\ub9cc DMSO\ub294 \ub354 \ub098\uc740 \uc138\ud3ec \ubd80\ub3d9\uc561\uacfc \ub354 \ub192\uc740 \ud50c\ub7ed\uc2a4\ub97c \uac16\ub294 \"\ubc94\uc6a9 \uc6a9\ub9e4\"\ub97c \ucc3e\uae30 \uc804\uc5d0 \uace0\uc720\ud55c \ud2b9\uc131\ub3c4 \uac00\uc9c0\uace0 \uc788\uc74c\uc744 \uc54c \uc218 \uc788\uc2b5\ub2c8\ub2e4. , \uc0dd\ubb3c\ud559\uc801 \uc2e4\ud5d8 \ubc0f \uc57d\ubb3c \uc608\ube44 \uc2a4\ud06c\ub9ac\ub2dd \ub2e8\uacc4\uc5d0\uc11c\ub3c4 DMSO\uc758 \ud569\ub9ac\uc801\uc778 \uc0ac\uc6a9\uc744 \ud1b5\ud574 \uc2dc\uc57d \uac04\uc12d \u200b\u200b\uc5c6\uc774 \uc2e0\uc18d\ud558\uac8c \uc815\ud655\ud55c \uc2e4\ud5d8 \uacb0\uacfc\ub97c \uc5bb\uc744 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc2e4\ud5d8\uc5d0\uc11c DMSO\ub97c \uc62c\ubc14\ub974\uac8c \uc0ac\uc6a9\ud558\ub294 \ubc29\ubc95\uc744 \uc0b4\ud3b4\ubcf4\uaca0\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc138\ud3ec \uc2e4\ud5d8\uc5d0\uc11c DMSO\ub97c \uc62c\ubc14\ub974\uac8c \uc0ac\uc6a9\ud558\ub294 \ubc29\ubc95\uc740 \ubb34\uc5c7\uc785\ub2c8\uae4c?<\/p>\n

1. \uc138\ud3ec\ub3d9\uacb0\uc81c<\/p>\n

DMSO\ub294 \ud604\uc7ac \uc138\ud3ec \ub0c9\ub3d9 \ubcf4\uc874\uc744 \uc704\ud55c \ucd5c\uace0\uc758 \ubcf4\ud638\uc81c\uc774\uc9c0\ub9cc \ud2b9\uc815 \ub3c5\uc131\uc744 \uac00\uc9c0\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc77c\ubc18\uc801\uc73c\ub85c \uc0ac\uc6a9 \uc2dc \ub18d\ub3c4\ub294 \ucd5c\uc885 \ubd80\ud53c\uc758 10% \uc774\ud558\ub85c \uc870\uc808\ud558\uba70, \ub0b4\uc131\uc774 \uc57d\ud55c \uc138\ud3ec\uc758 \uacbd\uc6b0 8% \ub4f1 10% \uc774\ud558\ub85c \uc904\uc77c \uc218 \uc788\ub2e4. \ub514\uba54\ud2f8\uc124\ud3ed\uc0ac\uc774\ub4dc\ub294 \uc138\ud3ec\uac00 \ud68c\ubcf5\ub418\uba74 \uac00\ub2a5\ud55c \ud55c \ube68\ub9ac \uc53b\uc5b4\ub0b4\uc57c \ud569\ub2c8\ub2e4. \uadf8\ub807\uc9c0 \uc54a\uc73c\uba74 \uc2ec\uac01\ud55c \uc138\ud3ec \ub3c5\uc131\uc744 \uc720\ubc1c\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uadf8 \uacb0\uacfc, \ubc30\uc591\ubc30\uc9c0 \ub0b4 DMSO \ub18d\ub3c4\uac00 10%\uc77c \ub54c \uc138\ud3ec \uc131\uc7a5 \uc5b5\uc81c\uc728\uc774 \uac70\uc758 100%\uc5d0 \ub2ec\ud558\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\ub2e4. 1% \ub18d\ub3c4\uc5d0\uc11c \uc5b5\uc81c\uc728\uc740 35%\uc600\uc73c\uba70, 0.04% \ub18d\ub3c4\uc5d0\uc11c\ub3c4 DMSO\ub294 \uc138\ud3ec \uc131\uc7a5\uc5d0 \ubd80\uc815\uc801\uc778 \uc601\ud5a5\uc744 \ubbf8\ucce4\uc2b5\ub2c8\ub2e4.<\/p>\n

2. \uc138\ud3ec \ud22c\uc5ec \uc911 \ud654\ud569\ubb3c\uc758 \uc6a9\ub9e4<\/p>\n

\uc138\ud3ec\uc5d0 \uc6a9\ud574\ub41c \ud654\ud569\ubb3c\uc744 \ud22c\uc5ec\ud560 \ub54c DMSO\uc758 \uc6a9\ub7c9\uc744 \uc5c4\uaca9\ud558\uac8c \uc81c\uc5b4\ud574\uc57c \ud569\ub2c8\ub2e4. \uc11c\ub85c \ub2e4\ub978 \uc138\ud3ec\ub294 \uc11c\ub85c \ub2e4\ub978 \uc218\uc900\uc758 DMSO\uc5d0 \ubbfc\uac10\ud560 \uc218 \uc788\uc9c0\ub9cc, \uc774\uc81c \ub354 \ud5c8\uc6a9 \uac00\ub2a5\ud55c \uac83\uc740 DMSO \ud654\ud569\ubb3c\uc744 \uc138\ud3ec \ud22c\uc5ec\uc6a9\uc73c\ub85c \uc900\ube44\ud560 \ub54c DMSO\uc758 \ucd5c\uc885 \ub18d\ub3c4\uac00 0.1% \uc774\ub0b4\ub85c \uc870\uc808\ub418\uba70 \uc774\ub294 \uc138\ud3ec \uc2e4\ud5d8\uc5d0 \uac04\uc12d\uc774 \uc5c6\ub294 \uac83\uc73c\ub85c \uac04\uc8fc\ub429\ub2c8\ub2e4. \uc989, 1ml \ubc30\uc9c0\uc5d0 \ub4e4\uc5b4 \uc788\ub294 DMSO\uc758 \uc591\uc740 1\u03bcl\ub97c \ucd08\uacfc\ud560 \uc218 \uc5c6\uc2b5\ub2c8\ub2e4. \ubd80\ud53c\uac00 \uc774 \ube44\uc728\uc744 \ucd08\uacfc\ud558\ub294 \uac83\uc73c\ub85c \ud655\uc778\ub418\uba74 \uc57d\ubb3c \ub18d\ub3c4\ub97c \ub192\uc774\uac70\ub098 \uc218\uc131 \ub2e4\ub2e8\uacc4 \ud76c\uc11d\uc744 \uc0ac\uc6a9\ud558\uc5ec DMSO\uc758 \uc591\uc744 \uc904\uc77c \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

3. DMSO\uc758 \ub4f1\uae09\uacfc \ubb34\uade0\uc5ec\uacfc \ubc29\uc2dd\uc740 \ubb34\uc5c7\uc778\uac00\uc694?<\/p>\n

\ub0c9\ub3d9\ubcf4\uc874\uc5d0 \uc0ac\uc6a9\ub418\ub294 DMSO \ub4f1\uae09\uc740 \uc790\uccb4\uc801\uc73c\ub85c \uba78\uade0\ub41c Tissueculturegrade DMSO(\uc608: SigmaD2650)\uc5ec\uc57c \ud569\ub2c8\ub2e4. \ucc98\uc74c \ubcd1\uc744 \uac1c\ubd09\ud55c \ud6c4\uc5d0\ub294 \uc18c\ub7c9\uc744 \uba78\uade0\uc2dc\ud5d8\uad00\uc5d0 \ub098\ub204\uc5b4\uc11c 4\u2103\uc5d0\uc11c \ubcf4\uad00\ud574\uc57c DMSO\uc758 \uade0\uc5f4\uacfc \ubc18\ubcf5\uc801\uc778 \ub0c9\ub3d9\uacfc \ud574\ub3d9\uc5d0 \ub530\ub978 \uc720\ud574\ubb3c\uc9c8\uc758 \ubc29\ucd9c\uc744 \ubc29\uc9c0\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uadf8\ub9ac\uace0 \uc624\uc5fc \uac00\ub2a5\uc131\uc744 \uc904\uc774\uc138\uc694. DMSO\ub97c \ud544\ud130\ub9c1\ud558\ub824\uba74 DMSO \ub0b4\uc131 \ub098\uc77c\ub860 \ud544\ud130 \uba64\ube0c\ub808\uc778\uc744 \uc0ac\uc6a9\ud574\uc57c \ud569\ub2c8\ub2e4.<\/p>\n

DMSO \uc0ac\uc6a9 \uc2dc \ucc38\uace0 \uc0ac\ud56d<\/p>\n

1. \ud53c\ubd80 \uc811\ucd09\uc744 \ud53c\ud558\uc2ed\uc2dc\uc624<\/p>\n

\uc774\ubc88 \uc5f0\uad6c\ub97c \ud1b5\ud574 DMSO\ub294 \ubd84\uc790\ub7c9\uc774 \uc791\uace0 \ud53c\ubd80\ub97c \ud1b5\ud574 \uc27d\uac8c \ud761\uc218\ub41c\ub2e4\ub294 \uc0ac\uc2e4\uc774 \ubc1d\ud600\uc84c\uc2b5\ub2c8\ub2e4. \ud53c\ubd80\uac00 DMSO\uc5d0 \uc7a5\uae30\uac04 \ub178\ucd9c\ub418\uba74 \uad6d\uc18c \ud53c\ubd80 \uc790\uadf9 \ubc18\uc751, \uac00\ub824\uc6c0\uc99d, \uc791\uc5f4\uac10 \ub4f1 \uc791\uc740 \uad6d\uc18c \uc790\uadf9 \ubc18\uc751\uc774 \ub098\ud0c0\ub0a9\ub2c8\ub2e4. \uc2e4\ud5d8 \uc911 \uc608\ube44\uc6a9\uc73c\ub85c 1%-5% \uc554\ubaa8\ub2c8\uc544\uc218\ub97c \uc900\ube44\ud560 \uc218 \uc788\uc73c\uba70, \ud53c\ubd80\uac00 \uc5fc\uc0c9\ub41c \ud6c4\uc5d0\ub294 \ub2e4\ub7c9\uc758 \ubb3c\ub85c \uc53b\uc5b4\ub0b4\uace0 \uc554\ubaa8\ub2c8\uc544\uc218\ub97c \ud76c\uc11d\ud574\uc57c \ud569\ub2c8\ub2e4. \ub3d9\uc2dc\uc5d0, \ub2e4\ub978 \ub3c5\uc131 \ubb3c\uc9c8\uc744 \ud568\uc720\ud55c \ub514\uba54\ud2f8 \uc124\ud3ed\uc0ac\uc774\ub4dc \uc6a9\uc561\uacfc\uc758 \uc811\ucd09\ub3c4 \ud53c\ud574\uc57c \ud569\ub2c8\ub2e4. \ub514\uba54\ud2f8 \uc124\ud3ed\uc0ac\uc774\ub4dc\ub294 \ud53c\ubd80\uc5d0 \uce68\ud22c\ud558\uc5ec \ud2b9\uc815 \uc870\uac74\uc5d0\uc11c \ub3c5\uc131 \ubb3c\uc9c8\uc744 \ud53c\ubd80\ub85c \uac00\uc838\uc624\uae30 \ub54c\ubb38\uc785\ub2c8\ub2e4.<\/p>\n

2. DMSO \ud761\uc785\uc744 \ud53c\ud558\uc138\uc694<\/p>\n

DMSO \ud761\uc785\uc740 \uba54\uc2a4\uaebc\uc6c0, \uad6c\ud1a0, \ub9c8\ub298, \uc591\ud30c, \uad74 \ub0c4\uc0c8\uac00 \ub098\ub294 \ud638\uae30 \ud638\ud761\uacfc \uac00\uc7a5 \uc77c\ubc18\uc801\uc73c\ub85c \uad00\ub828\ub429\ub2c8\ub2e4. \uace0\ub18d\ub3c4\uc758 \ub113\uc740 \uba74\uc801 \uc0ac\uc6a9\uc740 \ud718\ubc1c\uc744 \ud53c\ud558\uae30 \uc704\ud574 \uc0ac\uc6a9\ud558\ub294 \uacbd\uc6b0 \uc2e0\uacbd \uae30\ub2a5\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\uace0 \uc6a9\ud608\ub85c \uc774\uc5b4\uc9c8 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\uacb0\ub860\uc801\uc73c\ub85c DMSO\uc5d0\ub294 \ud2b9\uc815 \ub3c5\uc131\uc774 \uc788\uc9c0\ub9cc \uc0ac\uc6a9\ud560 \uc218\ub294 \uc5c6\uc2b5\ub2c8\ub2e4. \uc801\uc808\ud55c \ub300\uc548\uc774 \uc5c6\ub2e4\uba74 \uc5f0\uad6c \ub370\uc774\ud130\ub97c \uc5bb\uae30 \uc704\ud574 \uc801\ub2f9\ud55c \uc591\uc758 DMSO\ub97c \uc801\uc6a9\ud558\ub294 \uac83\uc774 \ud5c8\uc6a9\ub429\ub2c8\ub2e4.<\/p>","protected":false},"excerpt":{"rendered":"

DMSO(Dimethylsulfoxide) was called a “miracle drug” when it was first discovered because of its widespread use, and then restricted by the FDA. How toxic are solvents that are widely disseminated, and how do we use them in our experiments? Today we will reveal the correct use of DMSO, the “universal solvent”, in cell and animal experiments. Introduction to DMSO Dimethylsulfoxide (DMSO) is a sulfur-containing organic compound whose structure is shown below. Physical properties: colorless odorless transparent liquid at room temperature, with strong hygroscopic, freezing point of 18.55\u2103, density and water close to 1.100g\/mL; Chemical properties: The molecular formula is (CH3) 2SO, because the structure has a hydrophilic thionyl group and two hydrophobic methyl groups, it can be miscible with aqueous solution and most organic solvents except petroleum ether; It can dissolve about 80% of the compounds, and most of the water-soluble compounds and fat-soluble compounds can be dissolved by it,\u2026<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[26],"attr":[],"class_list":["post-422","post","type-post","status-publish","format-standard","hentry","category-problems","tag-dmso"],"_links":{"self":[{"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/posts\/422","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/comments?post=422"}],"version-history":[{"count":5,"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/posts\/422\/revisions"}],"predecessor-version":[{"id":1496,"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/posts\/422\/revisions\/1496"}],"wp:attachment":[{"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/media?parent=422"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/categories?post=422"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/tags?post=422"},{"taxonomy":"attr","embeddable":true,"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/attr?post=422"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}