{"id":1814,"date":"2024-04-25T16:54:53","date_gmt":"2024-04-25T08:54:53","guid":{"rendered":"https:\/\/www.yearnintl.com\/?p=1814"},"modified":"2024-04-26T10:11:54","modified_gmt":"2024-04-26T02:11:54","slug":"performance-of-crosslinked-povidone-as-a-solubilizer","status":"publish","type":"post","link":"https:\/\/www.yearnintl.com\/ko\/problems\/performance-of-crosslinked-povidone-as-a-solubilizer\/","title":{"rendered":"\uac00\uc6a9\ud654\uc81c\ub85c\uc11c \uac00\uad50\uacb0\ud569\ub41c \ud3ec\ube44\ub3c8\uc758 \uc131\ub2a5"},"content":{"rendered":"

\ubd88\uc6a9\uc131 \ud65c\uc131 \uc81c\uc57d \uc131\ubd84(api)\uc758 \uacbd\uc6b0 \uc6a9\ud574 \uc18d\ub3c4\ub97c \ub192\uc774\ub294 \uac83\uc740 \uc81c\uc81c \uac1c\ubc1c\uc5d0\uc11c \uc8fc\uc694 \uacfc\uc81c\uc785\ub2c8\ub2e4. \ubcf8 \uc5f0\uad6c\uc758 \ubaa9\uc801\uc740 \uc2b5\uc2dd \ud3a0\ub9bf \ucc98\ubc29\uc5d0\uc11c \uc57d\ubb3c\uc758 \uc6a9\ud574\ub97c \uac1c\uc120\ud558\uae30 \uc704\ud55c \uc5ec\ub7ec \uc288\ud37c \ubd95\uad34\uc81c\uc758 \uc131\ub2a5\uc744 \ud3c9\uac00\ud558\ub294 \uac83\uc774\uc5c8\uc2b5\ub2c8\ub2e4. \ubd88\uc6a9\uc131 \uba5c\ub85d\uc2dc\uce84\uacfc \ud398\ub178\ud53c\ube0c\ub808\uc774\ud2b8\uac00 \ubaa8\ub378 \uc57d\ubb3c\ub85c \uc0ac\uc6a9\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n

\ucc98\ubc29\ub41c \uc591\uc5d0 \ub530\ub77c \uac00\uad50\ub41c Polyplasdone\u2122\uc740 \uc815\uc81c \uc81c\uc81c\uc5d0\uc11c \ubd88\uc6a9\uc131 \uc57d\ubb3c\uc758 \uc6a9\ucd9c\ub960\uc744 \ud06c\uac8c \uc99d\uac00\uc2dc\ud0a4\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4. \ubcf8 \uc5f0\uad6c\uc5d0\uc11c \uac80\ud1a0\ud55c \uc288\ud37c\ubd95\ud574\uccb4\ub294 \ub2e4\uc74c\uacfc \uac19\ub2e4.<\/p>\n

\uac00\uad50\ub41c Polyplasdone\u2122; \ub610 \ub2e4\ub978 \uac00\uad50\ub41c \ud3ec\ube44\ub3c8(1,2); \uac00\uad50 \ub098\ud2b8\ub968 \uce74\ub974\ubcf5\uc2dc\uba54\ud2f8 \uc140\ub8f0\ub85c\uc624\uc2a4; \ub098\ud2b8\ub968\uce74\ub974\ubcf5\uc2dc\uba54\ud2f8\uc804\ubd84; \uc800\uce58\ud658\ub3c4 \ud788\ub4dc\ub85d\uc2dc\ud504\ub85c\ud544\uc140\ub8f0\ub85c\uc624\uc2a4(L-HPC)<\/p>\n

Polyplasdone\u2122XL \ubc0f Ultra \uc0ac\uc591\uc740 \ubb3c\ub9ac\uc801, \ud654\ud559\uc801 \ud2b9\uc131(\ubd88\uc21c\ubb3c \ud568\ub7c9\ub9cc \ub2e4\ub984) \uce21\uba74\uc5d0\uc11c \ub3d9\uc77c\ud558\ubbc0\ub85c \uc774 \uae30\uc0ac\uc5d0\uc11c\ub294 \uc11c\ub85c \ubc14\uafd4\uc11c \uc5f0\uad6c\ud569\ub2c8\ub2e4. \ub2e4\ub978 \uac00\uad50\ub41c \ud3ec\ube44\ub3c8 1\uacfc 2\ub294 \uc785\uc790 \ud06c\uae30\ub9cc \ub2e4\ub974\uba70 \uc0c1\ud638 \uad50\ud658 \uc5f0\uad6c\ub3c4 \uc218\ud589\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc2dc\ud5d8 \ubc29\ubc95<\/p>\n

200mg \uba5c\ub85d\uc2dc\uce84 \uc815\uc81c\ub294 \uc2b5\uc2dd \uacfc\ub9bd\ud654 \ubc29\ubc95\uc73c\ub85c \uc81c\uc870\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n

Povidone Plasdone\u2122K29\/32\ub294 20% \uc5d0\ud0c4\uc62c \ubc30\uce58\uc5d0 \uc6a9\ud574\ub429\ub2c8\ub2e4. \ubd84\uc1c4\ub41c \uba5c\ub85d\uc2dc\uce84 \uacfc\ub9bd\uc744 \ub2e4\uc591\ud55c \uc288\ud37c \ubd84\ud574\uae30\ub85c \uccb4\uc9c8\ud569\ub2c8\ub2e4. \uacfc\ub9bd\uc5d0 \uc2a4\ud14c\uc544\ub974\uc0b0\ub9c8\uadf8\ub124\uc298\uacfc \uc2e4\ub9ac\uce74\ub97c \ucca8\uac00\ud558\uace0 \ud63c\ud569\ud55c\ub2e4. \ucd5c\uc885 \ud63c\ud569\ubb3c\uc744 \uc555\ucc29\ud558\uc600\uace0 \uc815\uc81c \uc911\ub7c9\uc740 200mg\uc774\uc5c8\uc2b5\ub2c8\ub2e4. \uc0dd\uc131\ub41c \uc815\uc81c\uc758 \uacbd\ub3c4, \ub450\uaed8, \ucde8\uc131 \ubc0f \ubd95\ud574 \uc2dc\uac04\uc744 \uce21\uc815\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc2b5\uc2dd\uacfc\ub9bd\ubc95\uc5d0 \uc758\ud55c \ud398\ub178\ud53c\ube0c\ub808\uc774\ud2b8 \uacbd\uad6c\ubd95\uad34\uc815 348mg\uc758 \uc81c\uc870(\ucd08\ubd95\ud574\uc81c 20%)<\/p>\n

Povidone Plasdone\u2122K29\/32\ub97c 15% \uc5d0\ud0c4\uc62c \ubc30\uce58\uc5d0 \uc6a9\ud574\uc2dc\ud0a8 \ud6c4 \ucc98\ubc29\ub7c9\uc758 \ub098\ud2b8\ub968 \ub3c4\ub370\uc2e4 \ud669\uc0b0\uc5fc\uc744 \uc6a9\ud574\uc2dc\ucf30\uc2b5\ub2c8\ub2e4. \ubd84\uc1c4\ub41c \ud53c\ub178\ud53c\ube0c\ub808\uc774\ud2b8 \uacfc\ub9bd, \ub2e4\uc591\ud55c \uc288\ud37c\ubd95\ud574\uc81c \ubc0f \ud398\ud37c\ubbfc\ud2b8 \ud5a5 \uad50\uc815\uc81c\ub97c \uccb4\ub85c \uccd0\ub0c5\ub2c8\ub2e4. \uacfc\ub9bd\uc5d0 \uc2a4\ud14c\uc544\ub974\uc0b0\ub9c8\uadf8\ub124\uc298\uacfc \uc2e4\ub9ac\uce74\ub97c \ucca8\uac00\ud558\uace0 \ud63c\ud569\ud55c\ub2e4. \ucd5c\uc885 \ud63c\ud569\ubb3c\uc744 \uc555\ucc29\ud558\uc600\uace0 \uc815\uc81c \uc911\ub7c9\uc740 348mg\uc774\uc5c8\uc2b5\ub2c8\ub2e4. \uc0dd\uc131\ub41c \uc815\uc81c\uc758 \uacbd\ub3c4, \ub450\uaed8, \ucde8\uc131 \ubc0f \ubd95\ud574 \uc2dc\uac04\uc744 \uce21\uc815\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc2b5\uc2dd \ud3a0\ub81b\ubc95\uc5d0 \uc758\ud55c \ud398\ub178\ud53c\ube0c\ub808\uc774\ud2b8 302.5mg \uc18d\ubc29\uc815(8% \ucd08\ubd95\ud574\uc81c) \uc81c\uc870<\/p>\n

\ud398\ub178\ud53c\ube0c\ub808\uc774\ud2b8 \uc18d\ubc29\uc131\uc815\uc758 \uc81c\uc870\ubc29\ubc95\uc740 \ud398\ub178\ud53c\ube0c\ub808\uc774\ud2b8 \uad6c\uac15\ubd95\ud574\uc815\uc758 \uc81c\uc870\ubc29\ubc95\uacfc \ub3d9\uc77c\ud569\ub2c8\ub2e4. \uc6a9\ucd9c\uc2dc\ud5d8\ubc29\ubc95\uc740 \ud398\ub178\ud53c\ube0c\ub808\uc774\ud2b8 \uad6c\uac15\ubd95\ud574\uc815\uacfc \ub3d9\uc77c\ud558\ub2e4.<\/p>\n

\uacb0\uacfc \ubc0f \ud1a0\ub860<\/p>\n

1. \uba5c\ub85d\uc2dc\uce84 \uc815\uc81c<\/p>\n

\uba5c\ub85d\uc2dc\uce84 \uc815\uc81c\uc758 \uc6a9\ud574 \uacb0\uacfc\ub294 \uc288\ud37c \ubd95\ud574\uc81c\ub97c \ud568\uc720\ud55c \uc815\uc81c\uac00 70% \uc57d\ubb3c \ubc29\ucd9c \ud45c\uc900\uc5d0 \ub3c4\ub2ec\ud558\uae30 \uc704\ud574 30\ubd84\uc774\ub77c\ub294 USP \uc694\uad6c \uc0ac\ud56d\uc744 \ucda9\uc871\ud560 \uc218 \uc788\uc74c\uc744 \ubcf4\uc5ec\uc8fc\uc5c8\uc2b5\ub2c8\ub2e4. \uc288\ud37c\ubd95\ud574\uc81c\ub97c \ud568\uc720\ud558\uc9c0 \uc54a\uc740 \uc815\uc81c\uc758 \uacbd\uc6b0 \uc57d\ubb3c \ubc29\ucd9c\ub960\uc774 \uac00\uc7a5 \ub0ae\uc2b5\ub2c8\ub2e4. \uac00\uad50\ub41c Polyplasdone\u2122XL-10\uc744 \ubd95\uad34\uc81c\ub85c \uc0ac\uc6a9\ud558\ub294 \uc815\uc81c\ub294 pH7.5 \uc644\ucda9\uc561\uc5d0\uc11c \uac00\uc7a5 \ube60\ub978 \uc57d\ubb3c \ubc29\ucd9c\uc744 \ub098\ud0c0\ub0c5\ub2c8\ub2e4.<\/p>\n

\"Dissolution<\/p>\n

\uadf8\ub9bc 1. pH7.5 \uc778\uc0b0\uc5fc \uc644\ucda9\uc561\uc5d0\uc11c Midloxicam \uc815\uc81c\uc758 \uc6a9\ucd9c \uacb0\uacfc<\/p>\n

2. \ud398\ub178\ud53c\ube0c\ub808\uc774\ud2b8 \uad6c\uac15\ubd95\ud574\uc815<\/p>\n

\ubb34\ud654\uacfc. 2 \ub178\ud53c\ube0c\ub808\uc774\ud2b8 \uad6c\uac15\ubd95\ud574\uc815\uc758 \uc6a9\ucd9c \uacb0\uacfc, \ucd08\ubd95\ud574\uc81c\ub97c \ud568\uc720\ud55c \uc815\uc81c\uac00 60\ubd84 \uc774\ub0b4\uc5d0 70%\uc758 \uc57d\ubb3c \ubc29\ucd9c\uc774\ub77c\ub294 USP \uc694\uac74\uc744 \ucda9\uc871\ud560 \uc218 \uc788\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4. \uc288\ud37c\ubd95\ud574\uc81c\ub97c \ud568\uc720\ud558\uc9c0 \uc54a\uc740 \uc815\uc81c\uc758 \uacbd\uc6b0 \uc57d\ubb3c \ubc29\ucd9c\ub960\uc774 \uac00\uc7a5 \ub0ae\uc2b5\ub2c8\ub2e4. \uac00\uad50\ub41c Polyplasdone\u2122Ultra\ub97c \ubd95\uad34\uc81c\ub85c \uc0ac\uc6a9\ud558\ub294 \uc815\uc81c\ub294 pH7.5 \uc644\ucda9\uc561\uc5d0\uc11c \uac00\uc7a5 \ub192\uc740 \uc57d\ubb3c \ubc29\ucd9c\uc744 \ub098\ud0c0\ub0c5\ub2c8\ub2e4.<\/p>\n

\"Dissolution<\/p>\n

\uadf8\ub9bc 2. 0.025M \ud669\uc0b0\ub3c4\ub370\uc2e4\ub098\ud2b8\ub968\uc5d0\uc11c \ube44\ud53c\ube0c\ub808\uc774\ud2b8 \uad6c\uac15\ubd95\ud574\uc815\uc758 \uc6a9\ucd9c \uacb0\uacfc<\/p>\n

\uadf8\ub9bc 3\uc740 fenofibrate\uac00 60\ubd84 \ub0b4\uc5d0 70%\uc758 \uc57d\ubb3c \ubc29\ucd9c\uc774\ub77c\ub294 USP \uc694\uad6c \uc0ac\ud56d\uc744 \ucda9\uc871\ud558\uc9c0 \ubabb\ud568\uc744 \ubcf4\uc5ec\uc90d\ub2c8\ub2e4. \uadf8\ub9bc 4\ub294 \ud398\ub178\ud53c\ube0c\ub808\uc774\ud2b8 \uad6c\uac15\ubd95\ud574\uc815\uc774 \uc18d\ubc29\uc815\ubcf4\ub2e4 \uc57d\ubb3c \ubc29\ucd9c\uc774 \ub354 \ub192\ub2e4\ub294 \uac83\uc744 \ubcf4\uc5ec\uc90d\ub2c8\ub2e4. \uc18d\ubc29\uc131 \uc815\uc81c\uc758 \ucd08\ubd95\ud574\uc81c \ud568\ub7c9\uc740 \ub0ae\uc2b5\ub2c8\ub2e4.<\/p>\n

\"60<\/p>\n

\uadf8\ub9bc 3. 0.025M \ub098\ud2b8\ub968 \ub3c4\ub370\uc2e4 \ud669\uc0b0\uc5fc \ud398\ub178\ud53c\ube0c\ub808\uc774\ud2b8 \uc2e0\uc18d \ubc29\ucd9c \uc815\uc81c\uc758 60\ubd84 \ub0b4 \uc6a9\ud574<\/p>\n

\"Comparison<\/p>\n

\uadf8\ub9bc 4. \ucd08\ubd95\ud574\uc81c 20%\uc640 8% \ud568\uc720 \uc815\uc81c\uc758 \uc6a9\ucd9c \ube44\uad50<\/p>\n

\uacb0\ub860<\/p>\n

\ucc98\ubc29\uc5d0 \uc288\ud37c\ubd95\ud574\uc81c\ub97c \ucca8\uac00\ud558\uba74 \ubd88\uc6a9\uc131 \uc57d\ubb3c(\uba5c\ub85d\uc2dc\uce84 \ubc0f \ud398\ub178\ud53c\ube0c\ub808\uc774\ud2b8)\uc758 \uc6a9\ud574\uc728\uc774 \ud06c\uac8c \uc99d\uac00\ud569\ub2c8\ub2e4. \ub610\ud55c, \uac00\uad50\ub41c Polyplasdone\u2122\uc744 \ud568\uc720\ud55c \uc815\uc81c\ub294 \ub2e4\ub978 \ucd08\ubd95\ud574\uc81c\ubcf4\ub2e4 \ub354 \ub192\uc740 \uc57d\ubb3c \ubc29\ucd9c \uc218\uc900\uc744 \ub098\ud0c0\ub0c8\uace0, \ub354 \ub192\uc740 \uc218\uc900\uc758 \uac00\uad50\ub41c Polyplasdone\u2122\uc744 \ud568\uc720\ud55c \ud398\ub178\ud53c\ube0c\ub808\uc774\ud2b8 \uc815\uc81c\ub294 \ub354 \ub192\uc740 \uc57d\ubb3c \ubc29\ucd9c \uc218\uc900\uc744 \ub098\ud0c0\ub0c8\uc2b5\ub2c8\ub2e4. \ubcf8 \uc5f0\uad6c\uc758 \ub370\uc774\ud130\ub97c \ubc14\ud0d5\uc73c\ub85c \uc6b0\ub9ac\ub294 \uac00\uad50\ub41c Polyplasdone\u2122\uc774 \ubd88\uc6a9\uc131 \uc57d\ubb3c\uc758 \uc6a9\ud574\ub97c \uac1c\uc120\ud558\uae30 \uc704\ud55c \uac00\uc6a9\ud654\uc81c\ub85c \uc0ac\uc6a9\ub420 \uc218 \uc788\uc74c\uc744 \uc778\uc2dd\ud588\uc2b5\ub2c8\ub2e4.<\/p>","protected":false},"excerpt":{"rendered":"

For insoluble active pharmaceutical components (apis), increasing the dissolution rate is a major challenge in formulation development. The objective of this study was to evaluate the performance of several super disintegrators to improve the dissolution of drugs in wet pellet prescription. The insoluble meloxicam and fenofibrate were used as model drugs. Depending on the amount prescribed, cross-linked Polyplasdone\u2122 has been shown to significantly increase the dissolution rate of insoluble drugs in tablet formulations. The super disintegrators examined in this study are as follows: Crosslinked Polyplasdone\u2122; Another crosslinked povidone (1,2); Crosslinked sodium carboxymethyl cellulose; Sodium carboxymethyl starch; Low substituted hydroxypropyl cellulose (L-HPC) Because the Polyplasdone\u2122XL and Ultra specifications are identical in terms of physical and chemical properties (differing only in impurity content), they will be studied interchangeably in this article. The other cross-linked POvidone 1 and 2 differ only in particle size, and the interchange study was also carried out. Test\u2026<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"attr":[126],"class_list":["post-1814","post","type-post","status-publish","format-standard","hentry","category-problems"],"_links":{"self":[{"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/posts\/1814","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/comments?post=1814"}],"version-history":[{"count":3,"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/posts\/1814\/revisions"}],"predecessor-version":[{"id":1823,"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/posts\/1814\/revisions\/1823"}],"wp:attachment":[{"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/media?parent=1814"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/categories?post=1814"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/tags?post=1814"},{"taxonomy":"attr","embeddable":true,"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/attr?post=1814"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}