{"id":1787,"date":"2024-04-24T11:43:23","date_gmt":"2024-04-24T03:43:23","guid":{"rendered":"https:\/\/www.yearnintl.com\/?p=1787"},"modified":"2024-04-24T11:43:39","modified_gmt":"2024-04-24T03:43:39","slug":"the-application-of-pvp-in-pharmaceutical-research-and-development","status":"publish","type":"post","link":"https:\/\/www.yearnintl.com\/ko\/problems\/the-application-of-pvp-in-pharmaceutical-research-and-development\/","title":{"rendered":"\uc81c\uc57d \uc5f0\uad6c \ubc0f \uac1c\ubc1c\uc5d0 PVP \uc801\uc6a9"},"content":{"rendered":"

PVP\ub294 \uc81c\uc57d \uc5f0\uad6c \ubc0f \uac1c\ubc1c\uc5d0\uc11c \ub9e4\uc6b0 \uc77c\ubc18\uc801\uc73c\ub85c \uc0ac\uc6a9\ub418\ub294 \uc81c\uc57d \uace0\ubd84\uc790 \uc7ac\ub8cc\uac00 \ub418\uc5c8\uc73c\uba70 \uadf8 \uc7a5\uc810\uc774 \uc810\uc810 \ub354 \uc778\uc815\ub418\uc5b4 \uc131\uc219\ud55c \ub2e4\ubaa9\uc801 \uc81c\uc57d \ubd80\ud615\uc81c\uac00 \ub418\uc5c8\uc2b5\ub2c8\ub2e4. PVP\ub294 N-\ube44\ub2d0-2-\ud53c\ub9ac\ub180\ub77c\ub17c \ub2e8\ub7c9\uccb4\uc5d0 \uc758\ud574 \ucd09\ub9e4\ub418\ub294 \uc218\uc6a9\uc131 \uace0\ubd84\uc790\ub85c \ud761\uc2b5\uc131\uc774 \uc88b\uace0 \ubb3c, \uc5d0\ud0c4\uc62c \ub4f1 \uadf9\uc131 \uc720\uae30\uc6a9\ub9e4\uc5d0 \uc27d\uac8c \uc6a9\ud574\ub429\ub2c8\ub2e4. \uc57d\uc6a9 \ud3ec\ube44\ub3c8\uc758 \ubd84\uc790\ub7c9\uc740 10,000\uc5d0\uc11c 700,000 \uc0ac\uc774\uc774\uba70 \uc77c\ubc18\uc801\uc73c\ub85c K\uc758 \ud06c\uae30\ub85c \ud45c\uc2dc\ub418\uba70 K\uac00 \ud074\uc218\ub85d \ubd84\uc790\ub7c9\uc774 \ub192\uc2b5\ub2c8\ub2e4. PVP\ub294 \ub9ce\uc740 \uc6b0\uc218\ud55c \ud2b9\uc131\uc744 \uac00\uc9c0\uace0 \uc788\uc73c\uba70 \uc57d\uad6d\uc5d0\uc11c\uc758 \uc751\uc6a9\uc774 \uc810\uc810 \ub354 \uad11\ubc94\uc704\ud574\uc9c0\uace0 \uc801\uc6a9\uc131\uc774 \ub192\uc544\uc9c0\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ub2e4\uc74c\uc740 \uc911\uad6d\uc758 \uc758\uc57d\ud488 \uc81c\uc81c \uac1c\ubc1c \ubc0f \uc5f0\uad6c\uc5d0 \ub300\ud55c \uc751\uc6a9\uc758 \uc8fc\uc694 \uce21\uba74\uc785\ub2c8\ub2e4.<\/p>\n

\"Povidone<\/p>\n

\uac8c\uc774\uc9c0(\ubd84\uc790\ub7c9 MW)
PVPK15 (8,000)
PVPK25 (30,000)
PVPK30 (50,000)
PVPK60 (400,000)
PVPK90 (1,000,000)
\uc5f4\uc6d0 \uc5c6\uc74c C\ub4f1\uae09 PVPK120 (3,000,000)<\/p>\n

1. \uacbd\uad6c \uace0\ud615 \uc81c\uc81c\uc6a9 \uc811\ucc29\uc81c<\/p>\n

PVP\ub294 \ubb3c\uacfc \uc77c\ubc18\uc801\uc73c\ub85c \uc0ac\uc6a9\ub418\ub294 \uc77c\ubd80 \uc720\uae30 \uc6a9\ub9e4\uc5d0 \uc6a9\ud574\ub418\ubbc0\ub85c \ub2e4\uc591\ud55c \uc0c1\ud669\uc5d0\uc11c \uc0ac\uc6a9\ud558\uae30\uc5d0 \uc801\ud569\ud569\ub2c8\ub2e4. \uc6b0\uc120, \uc2b5\uae30\uc640 \uc5f4\uc5d0 \ubbfc\uac10\ud55c \uc57d\ubb3c\uc758 \uacbd\uc6b0 PVP \uc5d0\ud0c4\uc62c \uc6a9\uc561\uc744 \uacb0\ud569\uc81c\ub85c \uc0ac\uc6a9\ud558\uba74 \ubb3c\uacfc \uc5f4\uc758 \uc601\ud5a5\uc744 \uc81c\uac70\ud560 \uc218 \uc788\uc73c\uba70, \uc18c\uc218\uc131 \uc57d\ubb3c\uc758 \uacbd\uc6b0 \uc218\uc6a9\uc561\uc744 \uade0\uc77c\ud558\uac8c \uc801\uc2e4 \uc218 \uc788\uace0 \uc57d\ubb3c \uc785\uc790 \ud45c\uba74\uc774 \uade0\uc77c\ud558\uac8c \uc816\uc5b4\ub4e4 \uc218 \uc788\ub2e4. \uce5c\uc218\uc131\uc774 \uc788\uc5b4 \uc57d\ubb3c\uc758 \uc6a9\ud574\ub3c4\ub97c \ub192\uc774\ub294 \ub370 \ub3c4\uc6c0\uc774 \ub429\ub2c8\ub2e4. \ub610\ud55c, \uc811\ucc29\uc81c\ub85c\uc11c\uc758 PVP\ub97c \uac74\uc870 \ubd84\ub9d0\uacfc \ud568\uaed8 \ucca8\uac00\ud560 \uc218 \uc788\uc73c\uba70, \uc801\uc808\ud55c \uc6a9\ub9e4\ub85c \uc2b5\uc724 \uacfc\ub9bd\ud654\ud558\uac70\ub098 \uac74\uc870 \uc811\ucc29\uc81c\ub97c \uc9c1\uc811 \uc555\ucc29\ud568\uc73c\ub85c\uc368 \uc18c\uc218\uc131 \uc57d\ubb3c \ubc15\ub9ac \ud604\uc0c1\uc744 \uac1c\uc120\ud560 \uc218 \uc788\ub2e4. K30\uacfc K25\uac00 \uc77c\ubc18\uc801\uc73c\ub85c \uc0ac\uc6a9\ub418\uba70, PVPK30\uc758 \uc591\uc740 \uc77c\ubc18\uc801\uc73c\ub85c 2%-5%\uc785\ub2c8\ub2e4.<\/p>\n

\ubc1c\ud3ec\uc81c \uc0ac\uc6a9 \uc2dc PVP\ub294 \uc774\uc0c1\uc801\uc778 \uc811\ucc29\uc81c\uc785\ub2c8\ub2e4. \ubc1c\ud3ec\uc81c\ub294 \uc218\ubd84 \ud568\ub7c9\uc744 \uc5c4\uaca9\ud558\uac8c \uc81c\uc5b4\ud574\uc57c \ud558\uae30 \ub54c\ubb38\uc5d0 PVP \uc5d0\ud0c4\uc62c \uc6a9\uc561\uc744 \uacb0\ud569\uc81c\ub85c \uc0ac\uc6a9\ud558\uba74 \uc774 \ubb38\uc81c\ub97c \ud574\uacb0\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774 \ubc29\ubc95\uc73c\ub85c \uc81c\uc870\ub41c \ubc1c\ud3ec\uc815\uc740 \uc120\uba85\ub3c4\uac00 \uc88b\uace0 \uc6a9\ud574\uac00 \ube60\ub974\uba70 \uac70\ud488\uc774 \uac15\ud569\ub2c8\ub2e4. \uc57d 5%-10% PVP \uc6a9\uc561\uc744 \uacb0\ud569\uc81c\ub85c \uc0ac\uc6a9\ud558\uba74 \uc720\ub3d9\uce35 \ubd84\ubb34 \uac74\uc870 \uacfc\ub9bd\ud654\uc5d0\ub3c4 \uc0ac\uc6a9\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

2, \ub450\uaecd\uac8c\ud558\uace0 \uc810\uc131\uc744 \ub192\uc774\uae30 \uc704\ud574 \uacbd\uad6c \uc561\uc81c\uc5d0 \uc0ac\uc6a9\ub429\ub2c8\ub2e4.<\/p>\n

PVP\ub294 \uacbd\uad6c \uc561\uc81c\uc758 \uc99d\uc810\uc81c\ub85c\uc11c \uc624\ub79c \uc5ed\uc0ac\ub97c \uac00\uc9c0\uace0 \uc788\uc73c\uba70 \uc720\uc81c \ubc0f \ud604\ud0c1\uc561\uacfc \uac19\uc740 \uad11\ubc94\uc704\ud55c \uc751\uc6a9 \ubd84\uc57c\ub97c \uac00\uc9c0\uace0 \uc788\uc2b5\ub2c8\ub2e4. PVPK-90\uc740 \uc6b0\uc218\ud55c \uc99d\uc810 \uc548\uc815\uc81c\ub85c \uc0ac\uc6a9\ud560 \uc218 \uc788\uc73c\uba70 \uc911\ud569\uccb4\ub294 \ub2e8\uc77c \ud45c\uba74\uc5d0 \ud761\ucc29\ub429\ub2c8\ub2e4. \ucf5c\ub85c\uc774\ub4dc \uc774\uc628\uc774 \uc587\uc740 \ubd84\uc790\uce35\uc744 \ud615\uc131\ud558\uc5ec \uc751\uc9d1\uc744 \ubc29\uc9c0\ud569\ub2c8\ub2e4.<\/p>\n

3, \uace0\uccb4 \ubd84\uc0b0 \uce90\ub9ac\uc5b4\ub85c \uc0ac\uc6a9<\/p>\n

\uc0dd\uccb4 \ub0b4\uc5d0\uc11c \ubd88\uc6a9\uc131 \uc57d\ubb3c\uc758 \ud761\uc218\ub97c \ud5a5\uc0c1\uc2dc\ud0a4\ub294 \uac83\uc740 \ud56d\uc0c1 \ub728\uac70\uc6b4 \uc8fc\uc81c\uc600\uc73c\uba70, \uc774 \ubaa9\uc801\uc744 \ub2ec\uc131\ud558\uae30 \uc704\ud574 \uc6a9\ud574\ub3c4 \ubc0f \uc6a9\ud574 \uc18d\ub3c4\ub97c \ud5a5\uc0c1\uc2dc\ud0a4\ub294 \uac83\uc744 \uace0\ub824\ud569\ub2c8\ub2e4. \uace0\uccb4 \ubd84\uc0b0\uccb4\ub294 \ubb3c\uc5d0 \ubd84\uc0b0\ub41c \ubd84\uc790, \ucf5c\ub85c\uc774\ub4dc, \ubbf8\uc815\uc9c8 \ub610\ub294 \ubb34\uc815\ud615 \ud615\ud0dc\uc758 \ubd88\uc6a9\uc131 \uc57d\ubb3c\uc785\ub2c8\ub2e4. \uac00\uc6a9\uc131 \ubb3c\uc9c8\uc740 \uc6a9\ud574 \uc18d\ub3c4\uc640 \ud761\uc218\ub97c \ud06c\uac8c \ud5a5\uc0c1\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4. PVP\ub294 \uc2dd\uc0dd \uace0\uccb4 \ubd84\uc0b0\uc758 \uc77c\ubc18\uc801\uc778 \uc6b4\ubc18\uccb4\uc785\ub2c8\ub2e4.<\/p>","protected":false},"excerpt":{"rendered":"

PVP has become a very commonly used pharmaceutical polymer material in pharmaceutical research and development, and its advantages have been more and more recognized, making it a mature multi-purpose pharmaceutical excipients. PVP is a water-soluble polymer catalyzed by N-vinyl-2-pyrinolanone monomer, which is easily hygroscopic and easily soluble in polar organic solvents such as water and ethanol. The molecular weight of medicinal povidone is between 10,000 and 700,000, generally expressed by the size of K, the larger the K, the higher the molecular weight. PVP has many excellent properties, and its application in pharmacy is more and more extensive, more and more applicable, the following is the main aspects of its application in the development and research of pharmaceutical preparations in China. Gage (molecular weight MW)PVPK15 (8,000)PVPK25 (30,000)PVPK30 (50,000)PVPK60 (400,000)PVPK90 (1,000,000)No heat source C Grade PVPK120 (3,000,000) 1. Adhesive for oral solid preparation PVP is soluble in water and some commonly\u2026<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"attr":[121],"class_list":["post-1787","post","type-post","status-publish","format-standard","hentry","category-problems"],"_links":{"self":[{"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/posts\/1787","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/comments?post=1787"}],"version-history":[{"count":2,"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/posts\/1787\/revisions"}],"predecessor-version":[{"id":1789,"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/posts\/1787\/revisions\/1789"}],"wp:attachment":[{"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/media?parent=1787"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/categories?post=1787"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/tags?post=1787"},{"taxonomy":"attr","embeddable":true,"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/attr?post=1787"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}