{"id":1784,"date":"2024-04-24T11:35:06","date_gmt":"2024-04-24T03:35:06","guid":{"rendered":"https:\/\/www.yearnintl.com\/?p=1784"},"modified":"2024-04-24T11:35:06","modified_gmt":"2024-04-24T03:35:06","slug":"application-of-povidone-pvp-in-pharmaceutical-excipients","status":"publish","type":"post","link":"https:\/\/www.yearnintl.com\/ko\/problems\/application-of-povidone-pvp-in-pharmaceutical-excipients\/","title":{"rendered":"\uc758\uc57d\ud488 \ubd80\ud615\uc81c\uc5d0 \ud3ec\ube44\ub3c8 PVP \uc801\uc6a9"},"content":{"rendered":"

\uc758\uc57d\ud488 \ubd80\ud615\uc81c\ub85c\uc11c PVP\ub294 \uc815\uc81c \ubc0f \uacfc\ub9bd\uc81c\uc758 \uacb0\ud569\uc81c, \uc8fc\uc0ac\uc81c\uc758 \uacf5\uc6a9\ub9e4, \uc548\uc815\uc81c, \uc561\uc0c1\uc81c\uc81c\uc758 \ubd84\uc0b0\uc81c, \ucf54\ud305\ub9c9 \ud615\uc131\uc81c \ubc0f \uc0c9\uc18c\ubd84\uc0b0\uc81c, \uacf5\uce68\uc81c \ub4f1\uc73c\ub85c \uc8fc\ub85c \uc0ac\uc6a9\ub429\ub2c8\ub2e4. \ubd88\uc6a9\uc131 \uc57d\ubb3c, \uc548\uacfc\uc6a9 \uc9c0\uc5f0\uc791\uc6a9\uc81c, \uc724\ud65c\uc81c. \uc8fc\uc694 \uc0ac\ud56d\uc740 \ub2e4\uc74c\uacfc \uac19\uc2b5\ub2c8\ub2e4.<\/p>\n

\"Povidone<\/p>\n

l, \ubc14\uc778\ub354:<\/p>\n

\uc815\uc81c\ub294 \uc0dd\uc0b0, \uc6b4\uc1a1, \ud3ec\uc7a5 \ubc0f \ud310\ub9e4 \uacfc\uc815\uc5d0\uc11c \ubd88\uac00\ud53c\ud55c \ucda9\uaca9\uacfc \ub9c8\ucc30\uc744 \ubc1b\uc744 \ub54c \uae68\uc9c0\uc9c0 \uc54a\uace0 \uc591\ud638\ud55c \ubb3c\ub9ac\uc801 \ud2b9\uc131\uc744 \uc720\uc9c0\ud560 \uc218 \uc788\ub3c4\ub85d \uc77c\uc815\ud55c \uae30\uacc4\uc801 \uac15\ub3c4\ub97c \uac00\uc838\uc57c \ud569\ub2c8\ub2e4. \ub3d9\uc2dc\uc5d0 \ubcf5\uc6a9 \uc2dc \ub9cc\uc871\uc2a4\ub7ec\uc6b4 \uc131\ub2a5 \ud2b9\uc131\uc744 \uac00\uc9c0\uba70 \uc18c\ud654\uad00\uc5d0\uc11c \ube60\ub974\uac8c \ubd84\ud574\ub418\uc5b4 \uc57d\ubb3c\uc744 \ubc29\ucd9c\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774 \ubb38\uc81c\ub97c \ud574\uacb0\ud558\ub294 \uc5f4\uc1e0\ub294 \uc774\uc0c1\uc801\uc778 \ubc14\uc778\ub354\ub97c \uc120\ud0dd\ud558\ub294 \uac83\uc785\ub2c8\ub2e4. \uac15\ud55c \uacb0\ud569\ub825, \uc778\uccb4\uc640\uc758 \uc6b0\uc218\ud55c \uc0c1\uc6a9\uc131, \uc704\uc758 \uc694\uad6c \uc0ac\ud56d\uc744 \uc644\ubcbd\ud558\uac8c \ucda9\uc871\ud558\ub294 PVP\uc758 \uac15\ub825\ud55c \uc6a9\ud574\ub825\uc744 \uac16\ucd98 \uc2b5\uc2dd \uacfc\ub9bd, \uac74\uc2dd \uacfc\ub9bd \ub610\ub294 \uc9c1\uc811 \uc815\uc81c \uacf5\uc815 \uc81c\uc870 \uc5ec\ubd80\uc5d0 \uad00\uacc4\uc5c6\uc774 \ub2e4\uc591\ud55c \uc57d\ubb3c \uc815\uc81c\uc5d0 \ub110\ub9ac \uc0ac\uc6a9\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n

\ud761\uc2b5\uc131\uc774 \ub192\uc740 \uc57d\ubb3c\uc758 \uacbd\uc6b0 PVP\ub97c \ub2e4\ub978 \ubd84\ub9d0\uacfc \uac74\uc2dd \ud63c\ud569\ud55c \ud6c4 \uacfc\ub9bd\ud654\ud558\ub294 \ub3d9\uc548 \uc801\uc808\ud55c \uc6a9\ub9e4\ub85c \uc801\uc2e4 \uc218 \uc788\uc2b5\ub2c8\ub2e4. PVP\ub97c \uc0ac\uc6a9\ud558\uba74 \uc790\uc720\ub86d\uac8c \ud750\ub97c \uc218 \uc788\ub294 \uc555\ucd95\uc131 \uc785\uc790\ub97c \uc0dd\uc131\ud558\ub294 \ub370 \ub3c4\uc6c0\uc774 \ub418\uc5b4 \uc6a9\ud574\ub3c4\uac00 \uac15\ud55c \ub2e8\ub2e8\ud55c \uc815\uc81c\ub97c \uc5bb\uc744 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc815\uc81c\uc758 PVPK30\uc758 \ud22c\uc5ec\ub7c9\uc740 \uc77c\ubc18\uc801\uc73c\ub85c 2~5%\uc774\uba70, \uc0ac\uc6a9 \ub18d\ub3c4\ub294 \uc77c\ubc18\uc801\uc73c\ub85c 0.5~5%\uc785\ub2c8\ub2e4. PVPK90\uc758 \uacb0\ud569 \uc6a9\ub7c9\uc740 \uac15\ub825\ud558\uace0 \ubcf5\uc6a9\ub7c9\uc740 \uc57d 1-3%\ub85c \uc791\uc2b5\ub2c8\ub2e4. PVP\uc758 \ub192\uc740 \uc6a9\ud574\ub3c4\uc640 \uc870\uc808 \uac00\ub2a5\ud55c \uc810\ub3c4\ub294 \uacfc\ub9bd\ud654 \uc6a9\uc561\uc758 \ubd80\ud53c\ub97c \uc904\uc5ec \uac74\uc870 \uc2dc\uac04\uacfc \ube44\uc6a9\uc744 \uc904\uc785\ub2c8\ub2e4.<\/p>\n

PVP\ub294 \ubb3c\uacfc \uc5d0\ud0c4\uc62c\uacfc \uac19\uc740 \uc720\uae30\uc6a9\ub9e4 \ubaa8\ub450\uc5d0 \uc6a9\ud574\ub418\uae30 \ub54c\ubb38\uc5d0 PVP\ub294 \uc2e4\uc81c\ub85c \ub300\ubd80\ubd84\uc758 \ucc98\ubc29\uc5d0 \uc0ac\uc6a9\ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ud2b9\ud788 Chlormadinonum, Nitroglicerinum, Acidum Acetylsalicylicum \ub4f1\uacfc \uac19\uc740 \ubb3c\uc5d0 \ubbfc\uac10\ud558\uace0 \uc5f4\uc5d0 \ubbfc\uac10\ud558\uace0 \ud718\ubc1c\uc131\uc774 \uc788\ub294 \uc57d\ubb3c\uc758 \uacbd\uc6b0 PVP \uc54c\ucf54\uc62c \uc6a9\uc561\uc744 \uc0ac\uc6a9\ud558\uc5ec \uacfc\ub9bd\uc744 \ud615\uc131\ud558\uba74 \uc548\uc815\uc131 \ubb38\uc81c\ub97c \ud574\uacb0\ud560 \uc218 \uc788\uc744 \ubfd0\ub9cc \uc544\ub2c8\ub77c \uac74\uc870 \uc628\ub3c4\ub3c4 \ub0ae\ucdb0\uc8fc\uba70, \uac74\uc870 \uc2dc\uac04\uc744 \ub2e8\ucd95\ud558\uace0 \uc57d\ud488\uc758 \ud488\uc9c8\uc744 \ubcf4\uc7a5\ud569\ub2c8\ub2e4.<\/p>\n

(1) \uc2b5\uc2dd \uc7ac\ub8cc \ubc14\uc778\ub354<\/p>\n

\ub2e4\uc591\ud55c PVP \ud488\uc885\uacfc \uc0ac\uc591\uc740 \ub2e4\uc591\ud55c \uacfc\ub9bd\ud654 \ubc0f \ud544\ub984 \uc81c\uc870 \uacf5\uc815\uc5d0 \uc801\ud569\ud558\uba70 \uc0c8\ub85c \uc5bb\uc740 \uc815\uc81c\uc758 \ud2b9\uc131\ub3c4 \ub2e4\ub985\ub2c8\ub2e4.<\/p>\n

\uc2b5\uc2dd \ud3a0\ub81b \uc811\ucc29\uc81c\ub294 \ucc98\ubc29\uc804\uc744 \"\uc811\ucc29\uc131\"\uc73c\ub85c \ub9cc\ub4e4\uc5b4 \uc555\ucd95\uc131\uacfc \uc720\ub3d9\uc131\uc744 \ud5a5\uc0c1\uc2dc\ud0b5\ub2c8\ub2e4. \uc774\ub294 \uc815\uc81c\uc758 \ubb3c\ub9ac\uc801 \ud2b9\uc131\uc5d0 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud560 \ubfd0\ub9cc \uc544\ub2c8\ub77c \uc815\uc81c\uc758 \uc0dd\uccb4 \uc774\uc6a9\ub960 \ubc0f \ud6a8\ub2a5\uc5d0\ub3c4 \uc911\uc694\ud55c \uc601\ud5a5\uc744 \ubbf8\uce69\ub2c8\ub2e4.<\/p>\n

\ud3ec\ube44\ub3c8 \uc2dc\ub9ac\uc988 \uc81c\ud488\uc740 \uc2b5\uc2dd \uacfc\ub9bd\ud654\uc5d0 \uc120\ud638\ub418\ub294 \ud6a8\uc728\uc801\uc778 \uc811\ucc29\uc81c\uc785\ub2c8\ub2e4.<\/p>\n

(2) \uc9c1\uc811\uc815\uc81c \ubc0f \uac74\uc870\uc7ac\ub8cc \uc811\ucc29\uc81c<\/p>\n

\uc9c1\uc811 \uc555\ucc29 \ubc0f \uac74\uc2dd \uacfc\ub9bd\ud654\ub294 \uc815\uc81c \uc0dd\uc0b0\uc5d0\uc11c \uc810\uc810 \ub354 \ubcf4\ud3b8\ud654\ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uac74\uc2dd \uc811\ucc29\uc81c\ub294 \uc77c\ubc18\uc801\uc73c\ub85c \ub354 \ub098\uc740 \uc555\ucd95\uc131 \ucda9\uc804\uc7ac \ub610\ub294 \ucda9\uc804\uc7ac\ub85c \uad6c\uc131\ub429\ub2c8\ub2e4. \uc774\ub294 \ud65c\uc131 \uc131\ubd84\uc758 \uacb0\ud569 \ub2a5\ub825\uc744 \ud5a5\uc0c1\uc2dc\ud0a4\uace0 \uc815\uc81c \uc911\ub7c9\uc758 \uc0c1\ub2f9 \ubd80\ubd84\uc744 \ucc28\uc9c0\ud558\uba70 \ub300\ubd80\ubd84\uc758 \ucda9\uc804\uc7ac \uc811\ucc29\uc81c\ub294 \uc5b4\ub290 \uc815\ub3c4 \uc815\uc81c \ubd95\uad34\uc81c \uc5ed\ud560\ub3c4 \ud569\ub2c8\ub2e4. \uc81c\uc81c\uc5d0 \uace0\uc6a9\ub7c9\uc758 \uc57d\ubb3c\uc774 \ud3ec\ud568\ub418\uc5b4 \uc788\uac70\ub098 \ucda9\uc9c4 \uc811\ucc29\uc81c\uc758 \uc811\ucc29 \ud2b9\uc131\uc744 \ud5a5\uc0c1\uc2dc\ud0a4\ub294 \uacbd\uc6b0. \uc774\ub7ec\ud55c \uacbd\uc6b0, \ud2b9\ud788 \uc9c1\uc811 \uc555\ucc29\ud560 \uacbd\uc6b0 \uc811\ucc29\uc81c\ub294 \ubbf8\uc138\ud558\uac8c \ubd84\uc1c4\ub418\uc5b4\uc57c \ud558\uba70 \uc774\uc0c1\uc801\uc778 \ubd84\uc0b0\uc744 \ubcf4\uc7a5\ud558\uae30 \uc704\ud574 \ud2b9\ud788 \uc6b0\uc218\ud55c \ubd84\ub9d0 \ud750\ub984\uc744 \uac00\uc838\uc57c \ud569\ub2c8\ub2e4.<\/p>\n

2. \uacf5\uce68\uc804\uc81c<\/p>\n

\ub09c\uc6a9\uc131 \ubc0f \ubd88\uc6a9\uc131 \uc57d\ubb3c\uc758 \uc6a9\ud574\ub3c4, \uc6a9\ud574 \uc18d\ub3c4 \ubc0f \uc0dd\uccb4 \uc774\uc6a9\ub960\uc744 \ud5a5\uc0c1\uc2dc\ud0a4\ub294 \uac83\uc740 \uc81c\uc57d \uc5f0\uad6c \ubc0f \uc0dd\uc0b0\uc5d0\uc11c \ud574\uacb0\ud574\uc57c \ud560 \ubb38\uc81c\uc785\ub2c8\ub2e4.<\/p>\n

\ud6a8\ub2a5\uc774 \uc88b\uc740 \uc57d\ubb3c\uc740 \ub9ce\uc9c0\ub9cc \ubb3c\uc5d0 \ub300\ud55c \uc6a9\ud574\ub3c4\uac00 \ub0ae\uc544 \uc0dd\uccb4 \uc774\uc6a9\ub960\uc774 \ub5a8\uc5b4\uc9d1\ub2c8\ub2e4. \uc77c\ubd80 \uc218\uc6a9\uc131 \ub2f4\uccb4\ub97c \uc0ac\uc6a9\ud558\uc5ec \uc57d\ubb3c\uc744 \uacf5\uce68\uc2dc\ud0a4\uba74 \uc57d\ubb3c\uc758 \uc6a9\ucd9c \uc815\ub3c4\uc640 \uc6a9\ucd9c \uc18d\ub3c4\ub97c \ud5a5\uc0c1\uc2dc\ud0a4\uace0 \uce58\ub8cc \ud6a8\uacfc\ub97c \ud5a5\uc0c1\uc2dc\ud0a4\uba70 \ubcf5\uc6a9\ub7c9\uc744 \uc904\uc77c \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774 \uacf5\uce68\uc804\ubb3c\uc740 \uc791\uc740 \ubd84\uc790(\uac8c\uc2a4\ud2b8)\ub97c \ud3ec\ud568\ud558\ub294 \ud3f4\ub9ac\uba38(\uce90\ub9ac\uc5b4)\uc774\uba70, \ud2b9\uc815 \ubaa8\uc591, \ud06c\uae30 \ubc0f \ud2b9\uc815 \ubaa8\uc591, \ud06c\uae30 \ubc0f \uad6c\uc870\uc758 \ud070 \ubd84\uc790(\uc8fc\ub85c \ud3f4\ub9ac\uba38) \uacf5\uac04\uc5d0 \ucc44\uc6cc\uc9c4 \uc801\uc808\ud55c \uc791\uc740 \ubd84\uc790 \uc57d\ubb3c\uc785\ub2c8\ub2e4. \"\uace0\uccb4 \uc6a9\uc561\"\uc5d0 \uc758\ud574 \ud615\uc131\ub429\ub2c8\ub2e4.<\/p>\n

\uc57d\ubb3c-PVP \uacf5\uce68\uc804\uc5d0 \ub300\ud55c \uc5f0\uad6c\ub294 1960\ub144\ub300\uc5d0 \uc2dc\uc791\ub418\uc5c8\uc2b5\ub2c8\ub2e4. Tachibarla\ub294 PVP\ub97c \uc0ac\uc6a9\ud558\uc5ec B \uce74\ub85c\ud2f4\uc758 \uc6a9\ud574 \uc18d\ub3c4\ub97c \ud5a5\uc0c1\uc2dc\ud0a4\uae30 \uc704\ud574 B \uce74\ub85c\ud2f4\uc758 \uc218\ubd84\uc0b0\uc561\uc744 \uc81c\uc870\ud588\ub2e4\uace0 \ucc98\uc74c \ubcf4\uace0\ud588\uc2b5\ub2c8\ub2e4. \uadf8\ub9ac\uc138\uc624\ud480\ube48, Lixue \ubc0f PVP\uc758 \uacf5\uce68\uc804\ubb3c\uc758 \uc6a9\ud574\ub3c4, \uc6a9\ud574\uc728 \ubc0f \ud761\uc218\uc728\uc5d0 \ub300\ud55c \ud6c4\uc18d \uc5f0\uad6c\uac00 \ubb38\ud5cc\uc5d0 \uc790\uc8fc \ubcf4\uace0\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n

PVP \ubd84\uc790\uc758 \uce74\ub974\ubcf4\ub2d0\uacfc \ubd88\uc6a9\uc131 \uc57d\ubb3c \ubd84\uc790\uc758 \ud65c\uc131 \uc218\uc18c \uc6d0\uc790\uac00 \uc218\uc18c \uacb0\ud569\uc73c\ub85c \uacb0\ud569\ud558\uae30 \ub54c\ubb38\uc5d0 \uc57d\ubb3c \ubd84\uc790\ub294 \ube44\uc815\uc9c8\uc774 \ub418\uc5b4 \uc644\uc804\ud788 \uc218\uc6a9\uc131\uc778 PVP \uac70\ub300 \ubd84\uc790\uc5d0 \ub4e4\uc5b4\uac00 \ubd88\uc6a9\uc131 \uc791\uc740 \ubd84\uc790\uc758 \uacb0\uc815 \ud615\uc131\uacfc \uc131\uc7a5\uc744 \uc5b5\uc81c\ud569\ub2c8\ub2e4. \uc57d\ubb3c\uc774 \ubd88\ud3ec\ud654\ub418\uc5b4 \ubd88\uc6a9\uc131 \uc57d\ubb3c\uc758 \uc6a9\ud574\ub3c4\uac00 \ud06c\uac8c \ud5a5\uc0c1\ub429\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, \ud398\ub2c8\ud1a0\uc778\uc740 \ub09c\uc6a9\uc131 \uc57d\ubb3c\ub85c \uc77c\ubc18\uc801\uc73c\ub85c \uc720\ud6a8 \ud608\uc911 \ub18d\ub3c4(10-15\u03bcg\/ml)\uc5d0 \ub3c4\ub2ec\ud558\uc9c0 \ubabb\ud558\uc9c0\ub9cc, PVP\ub85c \ud615\uc131\ud560 \uacbd\uc6b0: 5\ub97c \uacf5\uce68\uc2dc\ud0a8 \ud6c4 \uc6a9\ud574\ub41c \ubc30\uc9c0 \ub0b4 \ud398\ub2c8\ud1a0\uc778\uc758 \ub18d\ub3c4\ub97c PH=1.2\ub294 \ud398\ub2c8\ud1a0\uc778\ubcf4\ub2e4 2.3\ubc30 \ub192\uc73c\uba70, \uacbd\uad6c \ud22c\uc5ec \ud6c4 2\uc2dc\uac04 \uc774\ub0b4\uc5d0 \uc720\ud6a8\ud608\uc911\ub18d\ub3c4\uc5d0 \ub3c4\ub2ec\ud560 \uc218 \uc788\uace0, \ub3c4\ub2ec\ud560 \uc218 \uc788\ub294 \ucd5c\ub300\ud608\uc911\ub18d\ub3c4\ub294 2\ubc30 \uc774\uc0c1 \uc99d\uac00\ud55c\ub2e4.<\/p>\n

\uc778\ub3cc \uc54c\uce7c\ub85c\uc774\ub4dc \ubaa8\ub974\ud3f4\ub9b0\uc758 \ubb3c\uc5d0 \ub300\ud55c \uc6a9\ud574\ub3c4\uc640 \uc6a9\ud574\uc728\uc740 \ub9e4\uc6b0 \ub0ae\uc73c\uba70, 30\u2103\uc5d0\uc11c\uc758 \uc6a9\ud574\uc728 \uc0c1\uc218\ub294 0.023min-1\uc774\uc9c0\ub9cc, 1:5\uc758 PVP \uacf5\uce68\ubb3c\uc740 10\ubd84 \uc774\ub0b4\uc5d0 \uc6a9\ud574\ub3c4\ub97c 38\ubc30 \uc99d\uac00\uc2dc\ucf30\uc744 \ubfd0\ub9cc \uc544\ub2c8\ub77c, \ub610\ud55c \uc6a9\ud574\uc18d\ub3c4\uc0c1\uc218\ub294 130\ubc30 \uc99d\uac00\ud558\uc5ec 2.99min-1\uc5d0 \ub3c4\ub2ec\ud558\uc600\uace0 PVP \ub18d\ub3c4\ub294 0.6\u00d710-3m \uc99d\uac00\ud558\uc600\uace0 \uc6a9\ud574\ub3c4\ub294 1\u00d710-3m \uc99d\uac00\ud558\uc600\ub2e4. \uc774\ub294 \uac01 PVP \ubd84\uc790\uac00 \ubaa8\ub974\ud3f4\ub9b0\uacfc \uc218\uc18c\uacb0\ud569\ud558\ub294 \ubd84\uc790\uc758 \uc218\uac00 \uc77c\uc815\ud558\uace0, PVP\uc758 \uc0c1\ub300\uc801 \ud568\ub7c9\uc774 \uc99d\uac00\ud560\uc218\ub85d \uacb0\ud569\ub41c \uc0c1\ud0dc\uc758 \ubaa8\ub974\ud3f4\ub9b0 \ubd84\uc790\uc758 \ube44\uc728\uc774 \uc99d\uac00\ud558\uc5ec \uc6a9\ud574\ub3c4\uac00 \ud5a5\uc0c1\ub418\uae30 \ub54c\ubb38\uc774\ub2e4.<\/p>\n

\ub808\uc138\ub974\ud540\uc758 \uc6a9\ud574 \uc18d\ub3c4\ub294 \uacb0\uc815 \ud06c\uae30\uc5d0 \ub530\ub77c \ud06c\uac8c \uc601\ud5a5\uc744 \ubc1b\uc2b5\ub2c8\ub2e4. 6~30\u03bcm\uc758 \uacb0\uc815\uc758 \uc6a9\ud574 \uc18d\ub3c4\ub294 \ub2e4\uc74c\uacfc \uac19\uc2b5\ub2c8\ub2e4.<\/p>\n

297~420\u03bcm \uacb0\uc815\uc758 6~7\ubc30. PVP\uac00 PVP\uc640 \uacf5\uce68\ub418\uba74 \uc785\uc790 \ud06c\uae30\uac00 \uc791\uc544\uc9c8 \uc218 \uc788\uc73c\ubbc0\ub85c PVP\uc640 \ub808\uc138\ub974\ud540 \uc790\uccb4\ub97c \ud63c\ud569\ud55c \uacbd\uc6b0\ubcf4\ub2e4 \ub808\uc138\ub974\ud540\uacfc PVP \uacf5\uce68\ubb3c\uc758 \uc6a9\ud574\ub3c4 \ubc0f \uc6a9\ud574\uc728\uc774 \ub354 \ub192\uc2b5\ub2c8\ub2e4. \uadf8\ub9ac\uace0 PVP\uc758 \ube44\uc728\uc774 \ud074\uc218\ub85d \uc6a9\ud574\ub3c4\uc640 \uc6a9\ud574 \uc18d\ub3c4\uac00 \ube68\ub77c\uc9d1\ub2c8\ub2e4. 1:3 \uacf5\uce68\ubb3c\uacfc l:6 \uacf5\uce68\ubb3c(\uc785\uc790 \ud06c\uae30 297~420\u03bcm)\uc758 \uc6a9\ucd9c\ub960\uc740 \uc138\ub974\ud540(\uc785\uc790 \ud06c\uae30 6~30\u03bcm)\uc5d0 \ube44\ud574 15\ubc30, 200\ubc30 \ub192\uc558\uc73c\uba70, \uc6a9\ucd9c \ubc18\uac10\uae30\ub294 7, 0.5, 106\ubc30\uc600\ub2e4. \ubd84.<\/p>\n

PVP\uc640 \ud2b8\ub9ac\uba54\ud1a0\ud504\ub9bc(TMP)\uc758 \uacf5\uce68\uc740 TMP\uc758 \uc6a9\ud574\ub97c \ud5a5\uc0c1\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uacf5\uce68\ubb3c, \uc21c\uc218 TMP, PVP \ubc0f TMP\uc758 \uae30\uacc4\uc801 \ud63c\ud569\ubb3c\uc758 \uc6a9\ud574 \uc2dc\ud5d8\uc5d0\uc11c\ub294 PVP\uc640 TMP(3:1)\uc758 \uacf5\uce68\ubb3c\uc774 \uac00\uc7a5 \ube60\ub974\uac8c \uc6a9\ud574\ub418\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4.<\/p>\n

\uacf5\uce68\uc804\ubb3c\uc758 \uc57d\ubb3c \uc6a9\ud574 \uc18d\ub3c4\ub294 \ub610\ud55c \ub2e4\uc74c \uc2e4\uc2dc\uc608\uc5d0 \uc608\uc2dc\ub41c \ubc14\uc640 \uac19\uc774 PVP \ub300 \uc57d\ubb3c\uc758 \uc911\ub7c9\ube44\ub97c \ubcc0\uacbd\ud558\uc5ec \uc870\uc808\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, \uc2dc\ud074\ub85c\ud5e5\uc2e4\uc6b0\ub808\uc544 \uc544\uc138\ud14c\uc774\ud2b8\uc640 PVP\uc758 \uacf5\uce68 \uc2dc\uc2a4\ud15c\uc740 PVP \ud568\ub7c9\uc774 70% \uc774\uc0c1\uc5d0 \ub3c4\ub2ec\ud560 \ub54c \uc2dc\ud074\ub85c\ud5e5\uc2e4\uc6b0\ub808\uc544 \uc544\uc138\ud14c\uc774\ud2b8\uc758 \ubb34\uc815\ud615 \ubd84\uc0b0\uc744 \ubcf4\uc7a5\ud558\uc5ec \uc2e0\uc18d\ud55c \uc6a9\ud574 \ubaa9\uc801\uc744 \ub2ec\uc131\ud574\uc57c \ud569\ub2c8\ub2e4. \uadf8\ub807\uc9c0 \uc54a\uc73c\uba74 \uc57d\ubb3c\uc740 \ub2e4\uc74c\uc73c\ub85c \uc778\ud574 \uc6a9\ud574 \uc18d\ub3c4\ub97c \uac10\uc18c\uc2dc\ud0b5\ub2c8\ub2e4. \uacb0\uc815\ud654 \uc0c1\ud0dc\uc758 \ud615\uc131 \ubc0f \uc99d\uac00. \uc608\ub97c \ub4e4\uc5b4 PVP\uc640 \uadf8\ub9ac\uc138\uc624\ud480\ube48\uc758 \uc911\ub7c9\ube44\uc728\uc744 20:1\uc5d0\uc11c 5:1\ub85c \uc904\uc774\uba74 \uc6a9\ucd9c\uc18d\ub3c4\ub3c4 \uc810\ucc28 \uac10\uc18c\ud55c\ub2e4. PVP:SF\uc758 \uc911\ub7c9\ube44\ub97c 20:1\uc5d0\uc11c 3:1\ub85c \uc904\uc774\uba74 SF\uc758 \uc6a9\ud574\uc728\uc740 \uc810\ucc28 \ub192\uc544\uc9c0\uc9c0\ub9cc, PVP\uc758 \uc591\uc774 0\uc73c\ub85c \uc904\uc5b4\ub4e4\uba74 \uc6a9\ud574\uc728\uc740 \uac00\uc7a5 \ub0ae\uc544\uc9c4\ub2e4.<\/p>\n

PVP\uc758 \uc911\ud569\ub3c4\ub97c \ubcc0\uacbd\ud558\uba74 \uacf5\uce68\uc804\ubb3c\uc758 \uc57d\ubb3c \uc6a9\ud574 \uc18d\ub3c4\ub3c4 \uc870\uc815\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc77c\ubc18\uc801\uc73c\ub85c PVP\uc758 \uc911\ud569\ub3c4\uac00 \uc99d\uac00\ud558\uba74 \uc57d\ubb3c \uc6a9\ucd9c\ub960\uc740 \uac10\uc18c\ud55c\ub2e4. \uc608\ub97c \ub4e4\uc5b4, ST, SMZ \ubc0f STZ\ub294 \uac01\uac01 PVPK15, PVPK30 \ubc0f PVPK90\uacfc \uacf5\uce68\uc804\ubb3c\uc744 \ud615\uc131\ud558\uace0 \uc774\ub4e4\uc758 \uc6a9\ud574 \uc18d\ub3c4 V\ub294 \ub2e4\uc74c \uaddc\uce59\uc744 \ub530\ub985\ub2c8\ub2e4: VK15>VK30>Vk90, \ub514\ud788\ub4dc\ub85c\ud074\ub85c\ub85c\ud2f0\uc544\uc9c0\ub4dc, \uc124\ud30c\ud2f0\uc544\uc878, \ud074\ub85c\ub78c\ud398\ub2c8\ucf5c\uacfc \uac19\uc774 PVP\uc640 \ud568\uaed8 \ud615\uc131\ub41c \uae30\ud0c0 \uacf5\uce68\uc804\ubb3c, \ud478\ub85c\uc138\ubbf8\ub4dc, \ub514\uace1\uc2e0, \ud074\ub85c\ub85c\ud2f0\uc544\uc9c0\ub4dc, \ud558\uc774\ub4dc\ub85c\ucf54\ub974\ud2f0\uc190, \ud504\ub808\ub4dc\ub2c8\uc190 \ub4f1\ub3c4 \uc774 \uaddc\uce59\uc744 \ub530\ub974\uc9c0\ub9cc \ub2c8\ud2b8\ub85c\ud398\ub2c8\ub9ac\ub518\uacfc \ud398\ub2c8\ud1a0\uc778\uc740 \uc608\uc678\uc785\ub2c8\ub2e4.<\/p>\n

\ubd88\uc6a9\uc131 \uc57d\ubb3c\uc758 \uc6a9\ud574\ub3c4 \ubc0f \uc6a9\ucd9c\ub960\uc774 \uc99d\uac00\ud558\uba74 \uc704\uc7a5\uad00 \ud761\uc218\uc728 \ubc0f \ud608\uc911 \uc57d\ubb3c \ub18d\ub3c4\uac00 \uc99d\uac00\ud560 \uc218\ubc16\uc5d0 \uc5c6\uc73c\uba70, \uc57d\ubb3c\uc758 \uc0dd\uccb4\uc774\uc6a9\ub960\ub3c4 \uc99d\uac00\ud558\uac8c \ub429\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, \uc778\uccb4 \uc2e4\ud5d8\uc5d0\uc11c\ub294 \ud398\ub2c8\ud1a0\uc778-pvp \uacf5\uce68\uc804\ubb3c\uc758 \uc0dd\uccb4 \uc774\uc6a9\ub960\uc774 \ud22c\uc5ec \ud6c4 \ucc98\uc74c 10\uc2dc\uac04 \ub3d9\uc548 1.54\ubc30, 2.37\ubc30 \uc99d\uac00\ud55c \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4. PvP\uc758 \uc0dd\uccb4 \uc774\uc6a9\ub960\uc774 18.5\ubc30 \uc99d\uac00\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n

 <\/p>\n

3, \uacf5\uc6a9\ub9e4 \ub610\ub294 \ubd84\uc0b0 \uc548\uc815\uc81c<\/p>\n

\uc774\uc804 \uc139\uc158\uc5d0\uc11c \uc5b8\uae09\ud55c \uacf5\uce68\uc804\ubb3c\uc5d0\uc11c PVP\uc758 \uac00\uc6a9\ud654 \ud6a8\uacfc\ub294 \uc8fc\ub85c \uc815\uc81c\uc5d0\uc11c \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4.<\/p>\n

\uc800\ubd84\uc790\ub7c9 \u200b\u200bPVP(K \uac12 12,15,17)\ub294 \uc8fc\uc785 \uc2dc \uacf5\uc6a9\ub9e4 \ubd84\uc0b0\uc81c \ub610\ub294 \uacb0\uc815 \uc131\uc7a5 \uc5b5\uc81c\uc81c\ub85c \uc791\uc6a9\ud560 \uc218\ub3c4 \uc788\uc73c\uba70 \uc774\ub7ec\ud55c \uac00\uc6a9\ud654 \ud6a8\uacfc\ub294 \uc8fc\ub85c \uc57d\ubb3c\uacfc PVP\uc758 \uacb0\ud569\uc5d0 \uc758\ud574 \ubc1c\uc0dd\ud569\ub2c8\ub2e4.<\/p>\n

\uc8fc\uc0ac \ub610\ub294 \uc561\uccb4 \uc81c\uc81c\uc5d0\uc11c \uacf5\uc6a9\ub9e4 \ub610\ub294 \uc548\uc815\uc81c\uc778 PVP\uc5d0\ub294 \uc625\uc2dc\ud14c\ud2b8\ub77c\uc0ac\uc774\ud074\ub9b0, \ud14c\uc2a4\ud1a0\uc2a4\ud14c\ub860, \ub3c5\uc2dc\uc0ac\uc774\ud074\ub9b0, \ud504\ub85c\uac8c\uc2a4\ud14c\ub860, \uc124\ud30c\ud2f0\uc544\uc878, \uc5d0\ud2f8\uc2a4\ud2f8\ubca0\uc2a4\ud2b8\ub864, \uc54c\ub85c\ud478\ub9ac\ub180, \ud478\ub77c\ub178\ud0c0\uc874, \ud0c8\uc9c0 \ub300\ub450 \ub808\uc2dc\ud2f4, \ub514\ud398\ub2d0\ud5e5\uc2e0, \uc0ac\uc774\ud074\ub85c\ud5e5\uc0b0 \uc544\ubbf8\ub178\uc124\ud3ec\ub124\uc774\ud2b8 \ub4f1\uc774 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\ubd84\ub9d0\uc8fc\uc0ac\uc81c\uc5d0\ub294 \ubbf8\uad6d \uba38\ud06c, \uc0e4\ud478, \ub2e4\uc6b0\ucf00\ubbf8\uce7c\uc0ac\uc758 \ub9ac\ud31c\ud53c\uc2e0, \ud654\uc774\uc790\uc758 \ub3c5\uc2dc\uc0ac\uc774\ud074\ub9b0 \ub4f1\uc774 PVP\uc5d0 \ucd94\uac00\ub41c\ub2e4. \uc911\uad6d\uc5d0\uc11c\ub294 Bizouping \uc8fc\uc0ac\ub97c \uc704\ud55c \uc6a9\ub9e4 \uac15\ud654\uc81c\ub85c 2% PVP\ub97c \uc0ac\uc6a9\ud588\uc2b5\ub2c8\ub2e4. \uc8fc\uc0ac\uc6a9 \ud074\ub85c\ub78c\ud398\ub2c8\ucf5c \ud604\ud0c1\uc561\uc5d0 PVP\ub97c \ucca8\uac00\ud55c \uacbd\uc6b0 \uc785\uc790\uc758 \ubbf8\uc138\ub3c4\uac00 5\u03bcm \ubbf8\ub9cc\uc774\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n

\uacbd\uad6c \ub610\ub294 \uad6d\uc18c \uc561\uc0c1 \uc81c\uc81c\uc5d0\uc11c PVPK25 \ubc0f K30\uc758 \uc6a9\ud574 \ud6a8\uacfc\uc5d0 \ub300\ud55c \ub9ce\uc740 \uc608\uac00 \uc788\uc2b5\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, PVP\ub294 \ud504\ub85c\ud14c\uc544\uc81c\uc758 \uc548\uc815\uc131\uc744 \ud5a5\uc0c1\uc2dc\ud0a4\uace0 \uc561\uccb4\uc5d0\uc11c \uc124\ud0d5\uc758 \uacb0\uc815\ud654\ub97c \ubc29\uc9c0\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc77c\ubd80 \ubd88\uc6a9\uc131 \uc131\ubd84\uc740 \uc218\uc6a9\uc561\uc5d0\uc11c \uce68\uc804\ub418\uba70 PVP\ub97c \ucd94\uac00\ud558\uc5ec \uadf9\ubcf5\ud560 \uc218\ub3c4 \uc788\uc2b5\ub2c8\ub2e4. \ub300\ud45c\uc801\uc778 \uc81c\uc81c \uc911 \ud558\ub098\uac00 \ud30c\ub77c\uc138\ud0c0\ubab0 \uc2dc\ub7fd\uc778\ub370, \uc774\ub294 PVPK25\ub85c \uc57d\ubb3c\uc758 \uc6a9\ud574\ub3c4\ub97c \ub192\uc774\uace0 \uc4f4\ub9db\uc744 \uc904\uc5ec\uc900\ub2e4.<\/p>\n

PVPK25, K30 \ubc0f K90\uc740 \uacbd\uad6c \ubc0f \uad6d\uc18c \uc57d\ubb3c \ubd84\uc0b0\uc561(\uc608: \uc544\uc2dc\ucf54\ube44\uc5b4)\uc5d0\uc11c \uc548\uc815\uc81c\ub85c \uc0ac\uc6a9\ud560 \uc218\ub3c4 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ubd80\ud504\ub85c\ud39c; (\ub9c8\uac08\ub77c\ub808\uc774\ud2b8); \ub2c8\uc2a4\ud0c0\ud2f4; \ud398\ub2c8\ud1a0\uc778; \ud2b8\ub9ac\uba54\ud1a0\ud504\ub9bc; \uc124\ud3f0\uc544\ubbf8\ub4dc; \ud56d\uc0dd\uc81c, \uc544\uc774\uc2f1 \ubd84\uc0b0\uc561 \ub4f1\uc774 \uc788\uc2b5\ub2c8\ub2e4. PVPK90\uacfc PVPP\uc758 \uc870\ud569\uc740 \uc885\uc885 \ub9e4\uc6b0 \uc6b0\uc218\ud55c \uc548\uc815\ud654 \ud6a8\uacfc\ub97c \ub098\ud0c0\ub0c5\ub2c8\ub2e4.<\/p>\n

4. \ucf54\ud305\uc81c \ub610\ub294 \ud544\ub984\ud615\uc131\uc81c<\/p>\n

\uc57d\ubb3c\ud544\ub984 \ucf54\ud305\uc81c\uc5d0 PVPK25, K30\uc744 \ucca8\uac00\ud558\uba74 PVP\uc758 \ub192\uc740 \uc811\ucc29\ub825\uc73c\ub85c \uc778\ud574 \uc57d\ubb3c \ubca0\uc774\uc2a4\uc5d0 \ub300\ud55c \ucf54\ud305\uc81c\uc758 \uc811\ucc29\ub825\uc744 \ub192\uc77c \uc218 \uc788\uc744 \ubfd0\ub9cc \uc544\ub2c8\ub77c \ubd84\uc0b0\uc131\uc774 \uc6b0\uc218\ud558\uc5ec \ucf54\ud305 \ud604\ud0c1\uc561\uc758 \uc548\uc815\uc131\uc744 \ub192\uc774\uace0, \uc0c9\uc18c\uc758 \uc7ac\uacb0\ud569\uacfc \uc774\ub3d9. PVP\uc758 \uc6b0\uc218\ud55c \ud53c\ub9c9 \ud615\uc131\uc73c\ub85c \uc778\ud574 \uac74\uc870 \uc2dc \ucf54\ud305 \ud45c\uba74\uc758 \ubbf8\uc138\ud55c \uade0\uc5f4\ub3c4 \ubc29\uc9c0\ub429\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \uc218\uc6a9\uc131 PVP\ub294 \ud761\uc2b5\uc131\uc774 \uc27d\uace0 \uacf5\uae30 \uc911\uc5d0\uc11c \ub048\uc801\uac70\ub9bc\uc73c\ub85c \uc778\ud574 \ub2e8\uc77c \ud544\ub984 \ud615\uc131\uc81c\ub85c \uc0ac\uc6a9\ud560 \uc218 \uc5c6\uc73c\uba70 \uc140\ub8f0\ub85c\uc624\uc2a4 \uc720\ub3c4\uccb4, \uba54\ud0c0\ud06c\ub9b4\uc0b0, \uc218\uc9c0 \ubc0f \uae30\ud0c0 \ud544\ub984 \ud615\uc131\uc81c\uc640 \ud63c\ud569\ub418\uc5b4\uc57c \ud55c\ub2e4\ub294 \uc810\uc5d0 \uc720\uc758\ud574\uc57c \ud569\ub2c8\ub2e4. \uc54c\ucf54\uc62c\uc744 \ud568\uc720\ud55c \uc548\ub8cc \ubd84\uc0b0\uc561\uc740 \uc258\ub77d\uacfc PVP\ub85c \uc81c\uc870\ud560 \uc218 \uc788\uc73c\uba70, \ud2b9\ud788 \uc2a4\ud504\ub808\uc774 \ubc0f \uc720\ub3d9\uce35 \ucf54\ud305 \uc7a5\ube44\uc5d0\uc11c \uade0\uc77c\ud55c \ucf54\ud305\uc744 \uc5bb\uc744 \uc218 \uc788\uc73c\uba70, \ud53c\ub9c9 \ud615\uc131\uc81c\uc758 \ubb3c\uc5d0 \ub300\ud55c \uc6a9\ud574\uc728\uc744 \ud5a5\uc0c1\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

5, \uc9c0\uc5f0\uc81c, \uc11c\ubc29\uc81c<\/p>\n

\uc57d\ubb3c\uc758 \uc81c\uc5b4 \ubc29\ucd9c\uc740 \uc57d\ubb3c\uc758 \uc791\uc6a9 \uc2dc\uac04\uc744 \uc5f0\uc7a5\ud558\uace0 \uc57d\ubb3c\uc758 \uc791\uc6a9 \uac15\ub3c4\ub97c \uc81c\uc5b4\ud558\ub294 \u200b\u200b\uc0c8\ub85c\uc6b4 \uae30\uc220\uc785\ub2c8\ub2e4. PVP\ub294 \ub9ce\uc740 \uc57d\ubb3c\uacfc \ubd84\uc790 \uacb0\ud569\uc744 \uac16\uace0 \uc788\uae30 \ub54c\ubb38\uc5d0 PVP\uc640 \uc57d\ubb3c \uc0ac\uc774\uc758 \uacb0\ud569 \uc815\ub3c4\ub97c \uc870\uc808\ud558\uba74 \uccb4\ub0b4 \uc57d\ubb3c\uc758 \ubc29\ucd9c\uacfc \ud761\uc218\ub97c \uc5f0\uc7a5\uc2dc\ucf1c \ud6a8\uacfc\ub97c \uc9c0\uc5f0\uc2dc\ud0a4\uace0 \ubc29\ucd9c\uc744 \ub290\ub9ac\uac8c \ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774 \ud6a8\uacfc\ub294 \uc801\uc808\ud55c \ubd84\uc790\ub7c9\uacfc \ub18d\ub3c4\ub97c \uc120\ud0dd\ud558\uc5ec \uc870\uc815\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, \ub0ae\uc740 \ub18d\ub3c4\uc758 PVP\ub294 Hydroflumethiaziclum\uc758 \uc6a9\ud574\ub97c \uc5f0\uc7a5\ud558\ub294 \ubc18\uba74, \ub192\uc740 \ub18d\ub3c4\uc758 PVP\ub294 \uc6a9\ud574 \uc18d\ub3c4\ub97c \ud06c\uac8c \uc99d\uac00\uc2dc\ud0b5\ub2c8\ub2e4. PVP\ub294 \ud30c\ub77c\uc138\ud0c0\ubab0\ub8f8\uc758 \uc6a9\ud574\ub3c4\ub97c \uc99d\uac00\uc2dc\ud0ac \ubfd0\ub9cc \uc544\ub2c8\ub77c \uc6a9\ud574 \uc18d\ub3c4\ub3c4 \uc9c0\uc5f0\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub294 \uc6a9\uc561\uc758 \uc810\ub3c4\uac00 \uc99d\uac00\ud568\uc5d0 \ub530\ub77c \ud30c\ub77c\uc138\ud0c0\ubab0\uc758 \uc6a9\ud574\ub3c4\uac00 \uac10\uc18c\ud558\uace0 PVP\uc758 \ubd84\uc790\ub7c9\uacfc \ub18d\ub3c4\uac00 \ubaa8\ub450 \uc6a9\uc561\uc758 \uc810\ub3c4\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\uae30 \ub54c\ubb38\uc785\ub2c8\ub2e4. PVPK17, K30 \ubc0f K90\uc744 \uc0ac\uc6a9\ud558\uc5ec \uac01\uac01 1:9 \ud30c\ub77c\uc138\ud0c0\ubab0 \ubd84\uc0b0\uc561\uc744 \uc81c\uc870\ud588\uc2b5\ub2c8\ub2e4. \uadf8 \uacb0\uacfc, PVPK17\uacfc PVPK30\uc758 \uc6a9\ucd9c \uc18d\ub3c4\ub294 \ube44\uc2b7\ud55c \ubc18\uba74, PVPK90\uc758 \uc6a9\ucd9c \uc18d\ub3c4\ub294 \uac00\uc7a5 \ub290\ub9b0 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\ub2e4.<\/p>\n

PVP\uac00 \ucf5c\ub808\uc2a4\ud14c\ub864 \ubc0f \ud638\ub974\ubaac \uc57d\ubb3c\uc758 \uc6a9\ud574\uc728\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\ub3c4 PVP\uc758 \ud568\ub7c9\uacfc \uad00\ub828\uc774 \uc788\uc2b5\ub2c8\ub2e4. PVP\ub294 \uc804\uc790\uc758 \uc6a9\ud574\ub3c4\ub97c \uac10\uc18c\uc2dc\ud0a4\uace0 \ud14c\uc2a4\ud1a0\uc2a4\ud14c\ub860, \ud504\ub85c\uac8c\uc2a4\ud14c\ub860, \ub514\uc5d0\ud2f8\uc544\ubbfc-\uc5d0\ud2f8\uc2a4\ud2f8\ubca0\uc2a4\ud2b8\ub864 \ub4f1\uacfc \uac19\uc740 \ud6c4\uc790\uc758 \uc6a9\ud574\ub3c4\ub97c \uc99d\uac00\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uac10\uc18c \ub610\ub294 \uc99d\uac00 \uac12\uc740 PVP\uc758 \ub18d\ub3c4\uc5d0 \ube44\ub840\ud569\ub2c8\ub2e4.<\/p>\n

\ud398\ub2c8\uc2e4\ub9b0(Berlzyperlici\u00a8num), Chloramphenicdum, \uc778\uc290\ub9b0(Insulinum), \ub098\ud2b8\ub968 \uc0b4\ub9ac\uc2e4\uc0b0\uc5fc, \uc124\ud30c\ud2f0\uc544\uc878, \ud398\ub178\ubc14\ub974\ube44\ud0c8\ub8f8 \ubc0f \ud504\ub85c\ud544 \ud504\ub85c\uce74\uc774\ub118, \ucf54\ub974\ud2f0\uc18c\ub214, \ud30c\ub77c\ubbf8\ub178\ubca4\uc870\uc0b0, \ud30c\ub77c\uc138\ud0c0\ubab0\ub8f8\uc5d0 \ub300\ud55c 10-25% PVP \uc6a9\uc561\uc758 \ud6a8\uacfc\ub294 \ubaa8\ub450 \uc9c0\uc5f0 \ud6a8\uacfc\uac00 \uc788\ub294 \uac83\uc73c\ub85c \ubcf4\uace0\ub418\uc5c8\uc2b5\ub2c8\ub2e4. .<\/p>\n

6. \uc548\uc57d \ucca8\uac00\uc81c<\/p>\n

\uc548\uc57d\uc5d0 \uc77c\uc815\ub7c9\uc758 PVP\ub97c \ucca8\uac00\ud558\uba74 \uc57d\ubb3c\uc758 \uc6a9\ud574\ub3c4\ub97c \ub192\uc774\uace0 \ub208\uc5d0 \ub300\ud55c \uc57d\ubb3c\uc758 \uc790\uadf9\uc744 \uac10\uc18c\uc2dc\ud0a4\uba70 \ud53c\ub9c9 \ud615\uc131\uc744 \uc99d\uac00\uc2dc\ud0a4\uace0 \uc810\ub3c4\ub97c \ud5a5\uc0c1\uc2dc\ud0a4\uba70 \uc810\uc548\uc81c\uc758 \uc791\uc6a9\uc2dc\uac04\uc744 \uc5f0\uc7a5\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4. PVP\ub294 \uce5c\uc218\uc131\uc774\uba70 \uc724\ud65c\ud6a8\uacfc\uac00 \uc788\uc5b4 \uc778\uacf5\ub208\ubb3c\ub85c \uc0ac\uc6a9\ud560 \uc218 \uc788\uc73c\uba70, (\ucca8\uac00\ub7c9\uc740 2~10%), \ud2b9\ud788 \ucf58\ud0dd\ud2b8\ub80c\uc988 \ucc29\uc6a9\uc5d0 \uc801\ud569\ud569\ub2c8\ub2e4.<\/p>\n

Extrapharmacopeia Edition 28\uc5d0\ub294 2\ub144 \ub3d9\uc548 \uc720\ud6a8\ud55c PVP \uc548\uc57d \ucc98\ubc29\uc804 2\uac1c\uac00 \ud3ec\ud568\ub418\uc5b4 \uc788\uc2b5\ub2c8\ub2e4. \ud604\uc7ac \uc2dc\uc911\uc5d0 \ud310\ub9e4\ub418\uace0 \uc788\ub294 \uc218\uc785 \ucf58\ud0dd\ud2b8\ub80c\uc988\uc5d0\ub294 \uc18c\ub3c5\uc81c, \uc724\ud65c\uc81c \ub4f1\uc774 \ud3ec\ud568\ub418\uc5b4 \uc788\ub294 \uacbd\uc6b0\uac00 \ub300\ubd80\ubd84\uc778\ub370, PVP\uac00 \ud568\uc720\ub418\uc5b4 \uc788\ub294 \uacbd\uc6b0\uac00 \ub9ce\uc2b5\ub2c8\ub2e4. \uc9c0\uc18d\ud615 \uc544\uc774\ud544\ub984\uc758 \uad6d\ub0b4 \uc2dc\ubc94 \uc0dd\uc0b0\uc5d0\uc11c \ubaa8\uacf5 \uc720\ubc1c\uc81c\ub85c \ubc29\ucd9c \uc81c\uc5b4\uce35\uc5d0 PVP\ub97c \ucca8\uac00\ud588\ub294\ub370, \uc774\ub294 EVA\uc640 \uc798 \uc0c1\uc6a9\ub420 \uc218 \uc788\uc5b4 \uc544\uc774\ud544\ub984\uc774 \ub354\uc6b1 \ub9e4\ub044\ub7fd\uace0 \ubd80\ub4dc\ub7fd\uc2b5\ub2c8\ub2e4.<\/p>\n

7, \ucea1\uc290 \ud750\ub984 \ubcf4\uc870\uc81c<\/p>\n

\ucea1\uc290 \ucda9\uc804 \uae30\uacc4\ub85c \uc57d\ubb3c\uc744 \ucda9\uc804\ud558\ub294 \uacfc\uc815\uc5d0\uc11c \uac00\ubcbc\uc6b4 \ubd84\ub9d0\uc774 \ubc1c\uc0dd\ud558\uace0 \ube44\uc6a9\uc801\uc774 \uc791\uc740 \uacbd\uc6b0 1~2% PVP \uc5d0\ud0c4\uc62c \uc6a9\uc561\uc744 \ucca8\uac00\ud558\uc5ec \uacfc\ub9bd\ud654\ub97c \ub3d5\uace0 \ud750\ub984 \uc6a9\ub7c9\uc744 \ud5a5\uc0c1\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4. PVP\ub294 \uc0ac\uc774\ud074\ub85c\ub9cc\ub378\ub808\uc774\ud2b8, \ud504\ub85c\ud544\ud53c\ub77c\ubbfc, \ud558\uc774\ub4dc\ub85d\uc2dc\uc5d0\ud2f8 \ud53c\ub77c\ubbfc\uc0b0 \ubc0f \uc5d0\ud2f8 \ud30c\ud30c\ub9b0 \uc9c0\uc18d\ud615 \ucea1\uc290\uc744 \ud3ec\ud568\ud55c \uacbd\uc9c8 \ucea1\uc290\uc758 \uc720\ub3d9 \ubcf4\uc870\uc81c\ub85c \ud574\uc678\uc5d0\uc11c \uc0ac\uc6a9\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ubd80\ub4dc\ub7ec\uc6b4 \ud3a0\ub9bf\uc5d0 PVP\ub97c \uc801\uc6a9\ud55c \uc0ac\ub840\ub294 \uac70\uc758 \ubcf4\uace0\ub418\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4. Japan Chemical Pharmaceutical Company\uc758 \ub2c8\ud2b8\ub85c\ud398\ub2c8\ub518 \uc5f0\uc9c8 \ud3a0\ub9bf \uc81c\uc870 \uc2dc \ubd84\uc0b0\uc81c\ub85c \uc18c\ub7c9\uc758 PVP(2%)\ub97c \ucca8\uac00\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n

8. \ubd95\ud574\uc81c<\/p>\n

\uac00\uad50\ud3ec\ube44\ub3c8(Crosslinked POvidone)\uc73c\ub85c \uc54c\ub824\uc9c4 \uace0\ub3c4\ub85c \uac00\uad50\ub41c PVP\ub294 \ubd88\uc6a9\uc131 PVP(PVPP)\ub85c\uc11c \uc815\uc81c\ub098 \uacbd\uc9c8\ucea1\uc290\uc758 \ubd95\ud574\uc81c\ub85c \uc0ac\uc6a9\ud560 \uc218 \uc788\uc73c\uba70, \uc2b5\uc2dd\uc555\ucc29 \ub610\ub294 \uc9c1\uc811\uc555\ucc29\uc774 \uac00\ub2a5\ud569\ub2c8\ub2e4. PPVP\ub85c \ub9cc\ub4e0 \uc815\uc81c\ub098 \uacbd\uc9c8\ucea1\uc290\uc740 \ubb3c\uc5d0 \ub179\uc600\uc744 \ub54c \ube60\ub978 \uc218\ubd84\ud761\uc218\uc640 \ud33d\ucc3d\uc131\uc73c\ub85c \uc778\ud574 \uc81c\uc81c\uc5d0 \ub192\uc740 \uc2a4\ud2b8\ub808\uc2a4\ub97c \uc8fc\uc5b4 \uc81c\uc81c\uac00 \ube60\ub974\uac8c \ubd95\ud574\ub418\uac8c \ub429\ub2c8\ub2e4.<\/p>","protected":false},"excerpt":{"rendered":"

As a pharmaceutical excipient, PVP is mainly used as a binder for tablets and granules, a co-solvent for injections, a stabilizer, a dispersing agent for liquid preparations, a coating film forming agent and a pigment dispersing agent, a co-precipitating agent for insoluble drugs, a delayed action agent for ophthalmology, and a lubricant. The main points are described as follows: l, binder: The drug tablet should have a certain mechanical strength so that it will not be broken and maintain good physical properties when it is subjected to the inevitable impact and friction in the process of production, transportation, packaging and sales; At the same time, when taken, it has satisfactory performance characteristics and can quickly disintegrate in the digestive tract and release the drug. The key to solve this problem is to choose the ideal binder. Whether it is wet granule, dry granule or direct tablet process preparation of strong\u2026<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"attr":[120],"class_list":["post-1784","post","type-post","status-publish","format-standard","hentry","category-problems"],"_links":{"self":[{"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/posts\/1784","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/comments?post=1784"}],"version-history":[{"count":1,"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/posts\/1784\/revisions"}],"predecessor-version":[{"id":1786,"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/posts\/1784\/revisions\/1786"}],"wp:attachment":[{"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/media?parent=1784"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/categories?post=1784"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/tags?post=1784"},{"taxonomy":"attr","embeddable":true,"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/attr?post=1784"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}