{"id":1673,"date":"2024-04-07T14:59:24","date_gmt":"2024-04-07T06:59:24","guid":{"rendered":"https:\/\/www.yearnintl.com\/?p=1673"},"modified":"2024-04-07T14:59:24","modified_gmt":"2024-04-07T06:59:24","slug":"application-of-povidone-in-pharmacy","status":"publish","type":"post","link":"https:\/\/www.yearnintl.com\/ko\/problems\/application-of-povidone-in-pharmacy\/","title":{"rendered":"\uc57d\uad6d\uc5d0\uc11c\uc758 \ud3ec\ube44\ub3c8 \uc801\uc6a9"},"content":{"rendered":"

\ud3f4\ub9ac\ube44\ub2d0\ud53c\ub864\ub9ac\ub3c8(PolyvinylPyrrolidone), \uc601\uc5b4 \uc774\ub984: PVP\ub77c\uace0 \ubd88\ub9ac\ub294 \ud3f4\ub9ac\ube44\ub2d0\ud53c\ub864\ub9ac\ub3c8(PolyvinylPyrrolidone)\uc740 \uc790\uc720\ub77c\ub514\uce7c \uc911\ud569\uc5d0 \uc758\ud574 N-\ube44\ub2d0\ud53c\ub864\ub9ac\ub514\uc628(N-Vinylpyrrolidione, NVP\ub77c\uace0\ub3c4 \ud568)\uc73c\ub85c\ubd80\ud130 \ud0c1\uc6d4\ud55c \uc131\ub2a5\uc744 \ubc1c\ud718\ud558\ub294 \uad11\ubc94\uc704\ud55c \ube44\uc774\uc628\uc131 \uc218\uc6a9\uc131 \uace0\ubd84\uc790 \uc815\ubc00 \ud654\ud559\ubb3c\uc9c8\uc785\ub2c8\ub2e4. PVP\ub294 \uc6b0\uc218\ud55c \uc6a9\ud574\ub3c4, \ub0ae\uc740 \ub3c5\uc131, \ud544\ub984 \ud615\uc131, \uac00\uc6a9\ud654, \ucc29\ud654, \uc0dd\ub9ac\uc801 \uc801\ud569\uc131, \ud45c\uba74 \ud65c\uc131 \ubc0f \ud654\ud559\uc801 \uc548\uc815\uc131\uacfc \uac19\uc740 \uc6b0\uc218\ud55c \ubb3c\ub9ac\uc801, \ud654\ud559\uc801 \ud2b9\uc131\uc744 \ub9ce\uc774 \uac00\uc9c0\uace0 \uc788\uc2b5\ub2c8\ub2e4.
\u3010 \ud575\uc2ec\uc5b4 \u3011 \uc57d\uc6a9 \ud3ec\ube44\ub3c8
\uc758\uc57d\ud488 \uc81c\uc870 \uae30\uc220\uc758 \ubc1c\uc804\uc73c\ub85c POvidone\uc740 \ube44\uc774\uc628\uc131 \uc218\uc6a9\uc131 \uace0\ubd84\uc790 \ud654\ud569\ubb3c\uc758 \uc758\uc57d\ud488 \ubd80\ud615\uc81c\ub85c \uc810\uc810 \ub354 \uad11\ubc94\uc704\ud558\uac8c \uc0ac\uc6a9\ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4.
\ud3ec\ube44\ub3c8 \uacc4\uc5f4 \uc758\uc57d\ud488 \ubd80\ud615\uc81c\uc758 \uc6b0\uc218\ud55c \uc0dd\ub9ac\uc801 \uc801\ud569\uc131\uc740 \uace0\uc720\ud558\uace0 \ub3c5\ud2b9\ud55c \uc81c\ud488 \ud2b9\uc131\uc73c\ub85c \ud604\uc7ac\ub294 \uc140\ub8f0\ub85c\uc624\uc2a4 \uc720\ub3c4\uccb4, \uc544\ud06c\ub9b4 \ud654\ud569\ubb3c\uacfc \ud568\uaed8 3\ub300 \ud569\uc131 \uc758\uc57d\ud488 \ubd80\ud615\uc81c\uac00 \ub418\uc5c8\uc2b5\ub2c8\ub2e4.
\ud3ec\ube44\ub3c8 \uc2dc\ub9ac\uc988\ub294 \ub2e4\uc591\ud55c K \uac12\uc5d0 \ub530\ub77c \ub2e4\uc591\ud55c \ubaa8\ub378\ub85c \ub098\ub20c \uc218 \uc788\uc73c\uba70, \uadf8 \uc911 \uac00\uc7a5 \ub110\ub9ac \uc0ac\uc6a9\ub418\ub294 \ud488\uc885\uc740 K15, K30 \ubc0f K90\uc785\ub2c8\ub2e4. \uc911\uad6d \uc57d\uc804\uc5d0\ub294 K30\uc758 \ud488\uc9c8 \uae30\uc900\ub9cc \uae30\uc7ac\ub418\uc5b4 \uc788\ub294 \ubc18\uba74, \uc601\uad6d \ubc0f \ubbf8\uad6d \uc57d\uc804\uc5d0\ub294 \ubaa8\ub4e0 POvidone K \uc2dc\ub9ac\uc988\ub97c \uc804\uccb4 \uae30\uc900\uc73c\ub85c \uae30\uc7ac\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ud604\uc7ac, \uc758\uc57d\ud488 \ubd80\ud615\uc81c\uc778 \ud3ec\ube44\ub3c8\uc5d0\ub294 \ub9ce\uc740 \uc81c\uc81c\uac00 \uc788\uc2b5\ub2c8\ub2e4.
\ud558\ub098. \ud0dc\ube14\ub9bf\uc5d0 PVP \uc801\uc6a9<\/p>\n

\"Pharmaceutical
1.1 \uc811\ucc29\uc81c
\uc815\uc81c \uc81c\uc870\uc5d0\uc11c\ub294 \uc77c\ubc18\uc801\uc73c\ub85c K25 \ub610\ub294 K30\uc774 \uc0ac\uc6a9\ub429\ub2c8\ub2e4. PVP\ub294 \uc815\uc81c, \uacfc\ub9bd\uc81c \ub4f1\uc758 \uc99d\uc810\uc81c\ub85c \ub110\ub9ac \uc0ac\uc6a9\ub429\ub2c8\ub2e4. \uc0ac\uc6a9\ub7c9\uc740 \uc77c\ubc18\uc801\uc73c\ub85c 3~5%(W\/W), \uc811\ucc29\uc561\uc758 \ub18d\ub3c4\ub294 0.5~5%(W\/W)\uc785\ub2c8\ub2e4. \uc0ac\uc6a9\ub41c PVP\uc758 \uc591\uc740 \ud544\ub984\uc758 \uc778\uc7a5 \uac15\ub3c4\uc5d0 \uc9c1\uc811\uc801\uc778 \uc601\ud5a5\uc744 \ubbf8\uce60 \uc218 \uc788\uc73c\uba70, \uc77c\ubc18\uc801\uc73c\ub85c PVP\uc758 \uc591\uc774 \ub9ce\uc744\uc218\ub85d \ud544\ub984\uc758 \uc778\uc7a5 \uac15\ub3c4\uac00 \ucee4\uc9d1\ub2c8\ub2e4. \ub2e4\uc591\ud55c \ucca8\uac00 \ubc29\ubc95, \uc989 \ub0b4\ubd80 \ucca8\uac00 \ub610\ub294 \uc678\ubd80 \ucca8\uac00 \ubc29\ubc95\uc774 \uc815\uc81c\uc758 \ubd95\ud574 \uc2dc\uac04\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce69\ub2c8\ub2e4. \ub0b4\ubd80\ucca8\uac00\ub780 PVP\ub97c \uac74\uc870\ubd84\ub9d0 \uc0c1\ud0dc\uc758 \uc57d\ubb3c\ubd84\ub9d0\uacfc \ud63c\ud569\ud55c \ud6c4 \ubb3c\uc774\ub098 \uc720\uae30\uc6a9\ub9e4\uc5d0 \uc801\uc154 \uacfc\ub9bd\ud654\ud558\ub294 \uac83\uc744 \uc758\ubbf8\ud55c\ub2e4. \uc678\uc6a9\ubc95\uc774\ub780 PVP\ub97c \uc720\uae30\uc6a9\ub9e4\ub098 \ubb3c\uc5d0 \ub179\uc778 \ud6c4 \ud63c\ud569\uc57d\uc81c\ubd84\ub9d0\uc5d0 \ucca8\uac00\ud558\ub294 \ubc29\ubc95\uc744 \ub9d0\ud55c\ub2e4. WanLSCet al. \ub0b4\ubd80\uc811\ucc29\uc81c\ub85c \ub9cc\ub4e0 \ud544\ub984\uc758 \ubd95\ud574\uc2dc\uac04\uacfc \uc6a9\ud574\uc18d\ub3c4\ub294 \uc678\ubd80\uc811\ucc29\uc81c\ubcf4\ub2e4 \uae38\uc5c8\ub2e4. \ub0b4\ubd80 \ucca8\uac00\ub294 \ud2b9\ud788 \ud761\uc2b5\uc131\uc774 \ub192\uc740 \ub0b4\uc7a5 \ucd94\ucd9c\ubb3c \ubc0f \uc57d\ubb3c\uc5d0 \uc801\ud569\ud569\ub2c8\ub2e4. \uc720\ub3d9\uce35 \ubd84\ubb34\uac74\uc870 \uacfc\ub9bd\ud654(1\ub2e8\uacc4 \uacfc\ub9bd\ud654\ub77c\uace0\ub3c4 \ud568)\uac00 \uc0ac\uc6a9\ub429\ub2c8\ub2e4.
\ud604\uc7ac \uc815\uc81c \ud3a0\ub81b\ud654 \uacf5\uc815\uc758 \uc2e0\uae30\uc220\uc778 PVP\ub97c \uacb0\ud569\uc81c\ub85c \uc0ac\uc6a9\ud558\ub294 \uc720\ub3d9\uce35 \ud3a0\ub81b\ud654\uc5d0\uc11c PVP \ub18d\ub3c4, \ubd80\ud53c, \uc2a4\ud504\ub808\uc774 \uc18d\ub3c4 \ubc0f \ub85c\ub529\ub7c9\uc740 \uc81c\uc870\ub41c \uc785\uc790\uc758 \ud2b9\uc131\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\uba70 \uace0\ud488\uc9c8 \uc785\uc790\ub97c \uc5bb\uc744 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc800\ub18d\ub3c4, \uc18c\ub7c9, \uc791\uc740 \ubd84\uc0ac \uc18d\ub3c4, \ud070 \ub85c\ub529\ub7c9\uc73c\ub85c \uc900\ube44\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc774 \ubc29\ubc95\uc740 \ub2e4\uc591\ud55c \ud488\uc885\uc5d0 \uc801\ud569\ud569\ub2c8\ub2e4.
\uc678\uad6d\uc5d0\ub294 \uc815\uc81c \uc811\ucc29\uc81c\ub85c \ub2e4\uc591\ud55c \uc885\ub958\uc758 PVP\uac00 \uc788\uc73c\uba70 \uc77c\ubc18\uc801\uc73c\ub85c \uc804\ubd84, \ud558\uc774\ub4dc\ub85d\uc2dc\ud504\ub85c\ud544 \uba54\ud2f8 \uc140\ub8f0\ub85c\uc624\uc2a4, \ubbf8\uc138 \ubd84\ub9d0 \uc2e4\ub9ac\uce74\uac94 \ub4f1\uacfc \ud63c\ud569\ub418\uc5b4 \uc815\uc81c \uc555\ucd95 \uc911 \uc555\ucd95\uc131\uacfc \uc6a9\ud574 \uc131\ub2a5\uc744 \ud5a5\uc0c1\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4.
\uc218\ubd84\uacfc \uc5f4\uc5d0 \ubbfc\uac10\ud55c \uc57d\ubb3c\uc758 \uacbd\uc6b0 PVP(\uc77c\ubc18\uc801\uc73c\ub85c \uc5d0\ud0c4\uc62c \uc6a9\uc561)\uc758 \uc720\uae30\uc6a9\uc561\uc744 \uc0ac\uc6a9\ud558\uc5ec \uacfc\ub9bd\ud654\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub807\uac8c \ud558\uba74 \uc2b5\uae30\uc758 \uc601\ud5a5\uc744 \ud53c\ud558\uace0 \ud3ec\ud06c\uac00 \ub0ae\uc740 \uc628\ub3c4\uc5d0\uc11c \ube60\ub974\uac8c \uac74\uc870\ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4.
\uc18c\uc218\uc131 \uc57d\ubb3c\uc758 \uacbd\uc6b0 PVP\uc758 \uc218\ubd84 \uc6a9\ud574\ub97c \uacb0\ud569\uc81c\ub85c \uc0ac\uc6a9\ud558\ub294 \uac83\uc774 \uc801\ud569\ud558\ubbc0\ub85c \ucc9c\uc774 \uade0\uc77c\ud558\uac8c \uc816\uae30 \uc27d\uace0 \uc561\uccb4 \uc57d\ubb3c\uc758 \ud45c\uba74\uc774 \uce5c\uc218\uc131\uc774 \ub418\uc5b4 \uc57d\ubb3c\uc758 \uc6a9\ud574\uc5d0 \ub3c4\uc6c0\uc774 \ub429\ub2c8\ub2e4. \ud0dc\ube14\ub9bf\uc758 \ubd84\ud574.
\ubc1c\ud3ec\uc131 \uc815\uc81c\uc758 \uacbd\uc6b0. \uc77c\ubc18\uc801\uc73c\ub85c \ubc1c\ud3ec\uc815\uc5d0\ub294 \uc911\ud0c4\uc0b0\ub098\ud2b8\ub968\uacfc \uad6c\uc5f0\uc0b0\uc758 \ud63c\ud569\ubb3c\uc774 \ud568\uc720\ub418\uc5b4 \uc788\uc73c\uba70, PVP\uc758 \ubb34\uc218\uc5d0\ud0c4\uc62c \uc6a9\uc561\uc744 \uc0ac\uc6a9\ud558\uc5ec \uacfc\ub9bd\ud654\ud560 \uacbd\uc6b0 \uc0b0-\uc5fc\uae30 \ubc18\uc751\uc774 \uc77c\uc5b4\ub098\uc9c0 \uc54a\uc2b5\ub2c8\ub2e4. Vitaxol C \ubc1c\ud3ec\uc815\uc744 \ud568\uc720\ud55c \uc811\ucc29\uc81c\ub85c 5% PVP \ubb34\uc218 \uc5d0\ud0c4\uc62c \uc6a9\uc561\uc744 \uc0ac\uc6a9\ud558\uc5ec \uc81c\uc870\ub41c \uc785\uc790\ub294 \uc6b0\uc218\ud55c \uc555\ucd95\uc131, \ube60\ub978 \uc6a9\ud574 \ubc0f \uac15\ub825\ud55c \ubc1c\ud3ec \ud6a8\uacfc\ub97c \ub098\ud0c0\ub0c5\ub2c8\ub2e4.
\ube44\ub2d0\ud53c\ub864\ub9ac\ub3c8 \ube44\ub2d0 \uc544\uc138\ud14c\uc774\ud2b8 \uacf5\uc911\ud569\uccb4(Vinylpyrrolidone \u2013 VinylAcetateCopolymer, VPVAC, CAPE)\ub77c\uace0\ub3c4 \uc54c\ub824\uc9c4 PVP\/VA\ub294 PVP\ub97c \uae30\ubc18\uc73c\ub85c \uac1c\ubc1c\ub41c \uc2e0\uc81c\ud488\uc73c\ub85c \ubc31\uc0c9 \uacfc\ub9bd \ubd84\ub9d0, \ubb34\ucde8, \ubb34\ubbf8, \ubb34\ud761\uc2b5\uc131 \uc81c\ud488\uc785\ub2c8\ub2e4. \ubb3c, \ud568\uc218 \uc54c\ucf54\uc62c, \ubb34\uc218 \uc5d0\ud0c4\uc62c\uc5d0 \uc6a9\ud574\ub429\ub2c8\ub2e4. \uc6a9\ub9e4 \uc2b5\uc2dd \ud63c\ud569 \uacfc\ub9bd\ud654\ub85c \uc218\uc131 \uc5d0\ud0c4\uc62c\uc744 \uc0ac\uc6a9\ud558\ub294 \ubc1c\ud3ec\uc131 \uc815\uc81c\uc758 \uc81c\uc870\ub97c \uc704\ud55c \ucd5c\uace0\uc758 \uc811\ucc29\uc81c\uc774\uba70, \uc7a5\uc810\uc740 \ube44\ud761\uc2b5\uc131, \uc6b0\uc218\ud55c \uc555\ucd95\uc131, \uc544\ub984\ub2e4\uc6b4 \uc815\uc81c\uc785\ub2c8\ub2e4. \uc811\ucc29\uc81c \ub18d\ub3c4\ub294 \uc77c\ubc18\uc801\uc73c\ub85c 5% ~ 10%\uc774\uba70 \ubcf5\uc6a9\ub7c9\uc740 \uc77c\ubc18\uc801\uc73c\ub85c 2%~5%.
\uc539\uc5b4\uba39\ub294 \uc815\uc81c\uc6a9. \uc218\uc0b0\ud654\uc54c\ub8e8\ubbf8\ub284\uacfc \uac19\uc740 \uc0b0\uc131 \uc815\uc81c\uc5d0 \ud2b9\ud788 \uc88b\uc740 \uc811\ucc29\uc81c\uc785\ub2c8\ub2e4. \uadf8\uac83\uc740 \uc57d\ubb3c\uc758 \ubb3c \ubbfc\uac10\uc131 \ubb38\uc81c\ub97c \ud574\uacb0\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ubcf4\uad00 \uc911\uc5d0 \uc815\uc81c\uac00 \uc810\ucc28\uc801\uc73c\ub85c \uacbd\ud654\ub418\ub294 \uac83\uc744 \ubc29\uc9c0\ud558\uae30 \uc704\ud574 PVP \uc6a9\uc561\uc5d0 2%-3% \uae00\ub9ac\uc138\ub864\uc744 \ucca8\uac00\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.
\ud0c4\uc18c \uc870\uac01\uc6a9. \uce74\ubcf8\uc2dc\ud2b8\uc6a9 \uc811\ucc29\uc81c\ub85c\uc11c \uc815\uc81c \uc555\ucc29 \uacfc\uc815\uc5d0\uc11c \ubc15\ub9ac \ud604\uc0c1\uc744 \uac1c\uc120\ud560 \uc218 \uc788\uc744 \ubfd0\ub9cc \uc544\ub2c8\ub77c \uc815\uc81c\uac00 \ube60\ub974\uac8c \ubd84\ud574\ub418\uc5b4 \ud761\ucc29\ub825\uc774 \ud2b9\ud788 \uac15\ud574\uc9d1\ub2c8\ub2e4.
\uc9c1\uc811 \uc555\ucd95\uc6a9. PVP \uac74\uc870 \ubd84\ub9d0\uc740 \uc9c1\uc811 \ud0c0\uc815\uc744 \uc704\ud55c \uac74\uc870 \uc811\ucc29\uc81c\ub85c\ub3c4 \uc0ac\uc6a9\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc815\uc81c \ucc98\ubc29\uc5d0 \uc18c\uc218\uc131 \uc57d\ubb3c\uc774 \ub354 \ub9ce\uc73c\uba74 \uc815\uc81c\ub97c \ub204\ub97c \ub54c \uc815\uc81c\uac00 \ub5a8\uc5b4\uc9c0\ub294 \ud604\uc0c1\uc774 \ubc1c\uc0dd\ud558\uae30 \uc27d\uc2b5\ub2c8\ub2e4. PVP \uac74\uc870\ubd84\ub9d0\uc744 2%~3% \ucca8\uac00\ud558\uba74(K25 \uaddc\uaca9). \uc774\ub7ec\ud55c \uc0c1\ud669\uc740 \uac1c\uc120\ub420 \uc218 \uc788\uc73c\uba70, \uc810\ucc29 \ubc29\uc9c0\uc81c\uc640 \uc724\ud65c\uc81c\uc758 \uc591\uc744 \uc801\uc808\ud558\uac8c \ub298\ub824 \uc810\ucc29\uc744 \ubc29\uc9c0\ud574\uc57c \ud569\ub2c8\ub2e4.
\ubd84\uc0b0 \uc815\uc81c\uc6a9. PVP\ub294 \ubb3c\uc5d0 \uc6a9\ud574\ub418\uae30 \ub54c\ubb38\uc5d0 \uc815\uc81c \ubd84\uc0b0\uc6a9 \uacb0\ud569\uc81c\ub85c \uc790\uc8fc \uc0ac\uc6a9\ub429\ub2c8\ub2e4.
1.2 Disintegrators
PVP \ubd80\uc11c\uc5d0\uc11c\ub294 \uac00\uad50 \ud3f4\ub9ac\ube44\ub2d0\ud53c\ub864\ub9ac\ub3c8(Crospovidone, Cross-linkedpolyvinylpyrTolidone)\uc774\ub77c\uace0\ub3c4 \ubd88\ub9ac\ub294 \uace0\ubd84\uc790\ub7c9\uc758 \uc54c\uce78 \ucf00\ud1a4 \uac00\uad50\ub97c \uc704\ud55c \ube44\ub2d0\uc5d0 \ub300\ud55c \uc2e0\uc81c\ud488 \uac1c\ubc1c\uc744 \uae30\ubc18\uc73c\ub85c \ud569\ub2c8\ub2e4. \uc720\ub3d9\uc131\uc774 \uc88b\uc740 \ubc31\uc0c9\uc758 \ubd84\ub9d0\uc774\ub2e4. \uace0\ubd84\uc790\ub7c9 \ubc0f \uac00\uad50 \uad6c\uc870\ub85c \uc778\ud574 \ubb3c\uc5d0 \ubd88\uc6a9\uc131\uc774\ub098 \ubb3c\uc744 \ub9cc\ub098\uba74 \ube60\ub974\uac8c \ubb3c\uc744 \ub3c4\uc785\ud560 \uc218 \uc788\uc73c\uba70 \ud33d\uc724\ub7c9\uc774 150%~200% \uc99d\uac00\ud558\uc5ec \ub124\ud2b8\uc6cc\ud06c \uad6c\uc870\uc758 \ud655\uc7a5\uc744 \ucd09\uc9c4\ud558\uace0 \ubd84\ud574\ub97c \uc77c\uc73c\ud0b5\ub2c8\ub2e4. \uc218\uc6a9\uc131 \uace0\ubd84\uc790(\uc804\ubd84 \uc81c\uc678)\uac00 \ud761\uc218 \ud6c4 \ud33d\uc724\ub420 \ub54c \uace0\uc810\ub3c4\uc758 \uac94\uce35\uc744 \uc0dd\uc131\ud558\uc9c0 \uc54a\uc73c\ubbc0\ub85c \uc9c0\uc18d\uc801\uc778 \ubd95\ud574\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\uc9c0 \uc54a\uc73c\ubbc0\ub85c \uc815\uc81c\uc758 \ubd95\uad34\uc81c\ub85c \ub9ce\uc774 \uc0ac\uc6a9\ub418\uba70, \uadf8 \ud6a8\uacfc\ub294 \ud0c0\uc815\uc81c\ubcf4\ub2e4 \uc6b0\uc218\ud558\ub2e4. \uc804\ubd84\uc774\ub098 \uc54c\uae34\uc0b0 \ub098\ud2b8\ub968\uacfc \uac19\uc740 \ubd95\uad34\uc81c\uc758 \uac83\uc785\ub2c8\ub2e4. \ubcf8 \uc81c\ud488\uc744 \ud568\uc720\ud55c \uc815\uc81c\ub97c \uac00\uc555\ud560 \ub54c \uc555\ub825\uc744 \uac00\ud558\uba74 \uc815\uc81c\uc758 \uacbd\ub3c4\uac00 \uc99d\uac00\ud558\ub098, \ubd95\ud574\uc2dc\uac04\uc740 \uc555\ub825\uc5d0 \uac70\uc758 \uc601\ud5a5\uc744 \ubc1b\uc9c0 \uc54a\uc2b5\ub2c8\ub2e4. \ubd95\ud574 \uc2dc\uac04\uc740 \ub3d9\uc77c\ud55c \uc555\ub825 \ud558\uc5d0\uc11c \ub3d9\uc77c\ud55c \uc591\uc758 \uc804\ubd84, \ubcc0\uc131 \uc804\ubd84, \uac00\uad50 \uce74\ub974\ubcf5\uc2dc\uba54\ud2f8 \uc12c\uc720 \ucf00\uc774\ube14 \ubc0f \uba54\ud2f8 \uc140\ub8f0\ub85c\uc624\uc2a4\ub97c \ud568\uc720\ud55c \uc815\uc81c\ubcf4\ub2e4 \uc5ec\uc804\ud788 \ube60\ub985\ub2c8\ub2e4. USP XI \ubc0f NF\ub294 \uc815\uc81c\uc758 \ubd95\uad34\uc81c, \ucda9\uc804\uc81c \ubc0f \ubd80\ud615\uc81c\ub85c PVPP\ub97c \uc218\uc9d1\ud588\uc73c\uba70, \uc77c\ubc18\uc801\uc778 \ubcf5\uc6a9\ub7c9\uc740 20~80mg\/\uc815\uc785\ub2c8\ub2e4.
1.3 \ucf54\ud305 \uc7ac\ub8cc
\uc815\uc81c \ub2f9\uc758 \ud398\uc774\uc2a4\ud2b8\ub098 \ud544\ub984 \ucf54\ud305\uc561\uc5d0 PVP\ub97c \ucca8\uac00\ud558\uba74 \uae30\uc7ac\uc5d0 \ub300\ud55c \ucf54\ud305\uc81c\uc758 \uc811\ucc29\ub825\uc744 \ub192\uc77c \uc218 \uc788\uc73c\uba70, PVP\ub294 \ucc29\uc0c9 \ud544\ub984 \ucf54\ud305\uc561\uc5d0\uc11c \uc548\ub8cc \ubd84\uc0b0\uc81c\ub85c \uc0ac\uc6a9\ud558\uc5ec \uc548\ub8cc \ubd84\ud3ec\ub97c \uade0\uc77c\ud558\uac8c \ub9cc\ub4e4 \uc218\ub3c4 \uc788\uc2b5\ub2c8\ub2e4. \ucf54\ud305\uc81c\ub85c \uc0ac\uc6a9\uc2dc \uc811\ucc29\ud604\uc0c1\uc774 \ubc1c\uc0dd\ud560 \uc218 \uc788\uc73c\uba70, \ucf54\ud305 \ud6c4 \uc2b5\ud55c \uacf5\uae30\uc911\uc5d0\uc11c\ub294 \uc57d\uac04 \ubd80\ub4dc\ub7ec\uc6cc\uc9d1\ub2c8\ub2e4. \ud761\uc2b5\uc131\uc744 \ud5a5\uc0c1\uc2dc\ud0a4\uae30 \uc704\ud574\uc11c\ub294 \uc258\ub77d, \uae00\ub9ac\uc138\ub9b0 \ubaa8\ub178\uc544\uc138\ud14c\uc774\ud2b8 \uc2dd\ucd08 \ub4f1\uc744 \uc801\ub2f9\ub7c9 \ucca8\uac00\ud558\uace0, \ud544\ub984\uc758 \uc720\uc5f0\uc131\uc744 \uc99d\uac00\uc2dc\ud0a4\uae30 \uc704\ud574\uc11c\ub294 PEG6000\uc744 \ucca8\uac00\ud558\ub294 \uac83\uc774 \uc88b\uc2b5\ub2c8\ub2e4.
1.4 \uace8\uaca9\uc131 \uc11c\ubc29\uc815\uc6a9 \ubaa8\uacf5\uc720\ubc1c\uc81c
\ubf08\ub300\uc11c\ubc29\uc815\uc740 \uc57d\ubb3c\uc5d0 \ubd88\uc6a9\uc131 \uace0\ubd84\uc790 \ubc0f \uc218\uc6a9\uc131 \ubb3c\uc9c8(\uae30\uacf5\uc720\ub3c4\uc81c)\uc744 \ud63c\ud569\ud55c \ud6c4 \ud718\ubc1c\uc131\uc6a9\ub9e4\ub97c \ub179\uc5ec \uc6a9\ud574\uc2dc\ud0a4\uac70\ub098 \uc9c1\uc811 \uc555\ucc29\ud558\uc5ec \uc81c\uc870\ud55c \uace0\ud615\uc81c\uc758 \uc77c\uc885\uc785\ub2c8\ub2e4. PVP\ub294 \ubd88\uc6a9\uc131 \uace8\uaca9 \uc11c\ubc29\uc815 \ubc0f \uc218\uc6a9\uc131 \uace8\uaca9 \uc11c\ubc29\uc815\uc744 \uc81c\uc870\ud558\uae30 \uc704\ud55c \ub9e4\ud2b8\ub9ad\uc2a4 \uae30\uacf5 \uc720\ub3c4\uc81c\ub85c \uc0ac\uc6a9\ub420 \uc218 \uc788\ub2e4. Dakkuri \ub4f1\uc740 N-\ubca4\uc9c8-N', N'-\ub514\uba54\ud2f8-N \u2013(2-\ud53c\ub9ac\ub51c) \uc5d0\ud2f8\ub80c\ub514\uc544\ubbfc \uc5fc\uc0b0\uc5fc \uace8\uaca9 \uc9c0\uc18d \ubc29\ucd9c \uc815\uc81c\uc758 \ubc29\ucd9c\uc5d0 \ub300\ud55c \uae30\uacf5 \ud615\uc131\uc81c\ub85c\uc11c\uc758 \ubd80\ud2f8 PVP\uc758 \ud6a8\uacfc\ub97c \uc5f0\uad6c\ud588\uc2b5\ub2c8\ub2e4. \uc11c\ubc29\ud615 \uc815\uc81c\ub294 \uc6a9\uc735\ubc95\uc73c\ub85c \uc81c\uc870\ud558\uc600\ub2e4. PVP\uac00 \uc5c6\ub294 \ucc98\ubc29\uc5d0 \ube44\ud574 8\uc2dc\uac04 \ucd9c\uc2dc\uc778 5% PVP \ucc98\ubc29\uc740 37%, 20% PVP \ucc98\ubc29\uc740 55% \uc99d\uac00\ud588\ub2e4. 10% ~ 20% PVP\ub97c \ucca8\uac00\ud558\uba74 \uc6a9\ucd9c \ubaa8\ub4dc\uac00 \ucd5c\uc801\ud654\ub418\uc5b4 \uc57d\ubb3c\uc774 10%\/h\uc758 \uc18d\ub3c4\ub85c \ubc29\ucd9c\ub429\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \uc9c1\uc811\uc555\ucc29\ubc95\uc73c\ub85c \uc11c\ubc29\uc815\uc744 \uc81c\uc870\ud55c \uacbd\uc6b0 PVP \ucca8\uac00 \uc5ec\ubd80\uc640 \ucca8\uac00\ub7c9\uc740 \uc57d\ubb3c \ubc29\ucd9c\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\uc9c0 \uc54a\uc558\ub2e4. \ub530\ub77c\uc11c, PVP\ub97c \uace8\uaca9\uc131 \uc11c\ubc29\uc815\uc758 \uae30\uacf5\uc720\ubc1c\uc81c\ub85c \uc0ac\uc6a9\ud558\ub294 \uacbd\uc6b0, \uc81c\uc870\uacfc\uc815\uacfc PVP\uc758 \uc591\uc774 \uc815\uc81c\uc758 \uc6a9\ucd9c\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce60 \uc218 \uc788\ub2e4. \ud604\uc7ac PVP\ub294 \ubd80\ud0c0\ub514\uc5d4, \uc778\ub3c4\uba54\ud0c0\uc2e0, \ud669\uc0b0 \uc544\uc5f0, \uc774\ubd80\ud504\ub85c\ud39c \ubc0f \uae30\ud0c0 \uc11c\ubc29\uc131 \uc815\uc81c\ub97c \ub9cc\ub4e4\uae30 \uc704\ud55c \uae30\uacf5 \uc720\ub3c4\uc81c\ub85c \uc0ac\uc6a9\ub418\uc5b4 \uc654\uc2b5\ub2c8\ub2e4.
\ub458. PVP\ub97c \uc8fc\uc785\uc5d0 \uc801\uc6a9
PVP\uc758 3.5%(w\/v) \ub4f1\uc7a5\uc131 \uc8fc\uc785\uc740 \ud608\uc561\ub7c9 \ubcf4\ucda9\uc81c\ub85c \uc0ac\uc6a9\ud560 \uc218 \uc788\uc9c0\ub9cc \ud604\uc7ac\ub294 \uac70\uc758 \uc0ac\uc6a9\ub418\uc9c0 \uc54a\uc2b5\ub2c8\ub2e4. \uc8fc\uc785 \uce21\uba74\uc5d0\uc11c\ub294 \uacf5\uc6a9\ub9e4, \ubd84\uc0b0\uc81c, \uc9c0\uc5f0\uc81c \ub4f1\uc73c\ub85c \ub110\ub9ac \uc0ac\uc6a9\ub429\ub2c8\ub2e4. \ud574\uc678\uc5d0\uc11c\ub294 \ud654\uc774\uc790\uc758 \ub3c5\uc2dc\uc0ac\uc774\ud074\ub9b0 \ubd84\ub9d0\uc8fc\uc0ac\uc81c, \uba38\ud06c\uc758 \ub9ac\ud31c\ud53c\uc2e0 \ubd84\ub9d0\uc8fc\uc0ac\uc81c \ub4f1 \ubd84\ub9d0\uc8fc\uc0ac\uc81c\uc5d0 PVP\ub97c \ucca8\uac00\ud55c\ub2e4. L0-25pvp \uc6a9\uc561\uc744 \uc0ac\uc6a9\ud558\uba74 \ud398\ub2c8\uc2e4\ub9b0, \ucf54\ub974\ud2f0\uc190, \ud504\ub85c\uce74\uc778, \uc778\uc290\ub9b0 \ubc0f \uae30\ud0c0 \uc2e0\uccb4\uc758 \uc57d\ubb3c\uc774 \ucc9c\ucc9c\ud788 \ubc29\ucd9c\ub418\uc5b4 \ud6a8\uacfc\uac00 \uc5f0\uc7a5\ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ubcf4\ud638 \ucf5c\ub85c\uc774\ub4dc \ubc0f \ubd84\uc0b0\uc81c\ub85c\uc11c \uc8fc\uc0ac\uc6a9 \ud074\ub85c\ub78c\ud398\ub2c8\ucf5c \ud604\ud0c1\uc561\uc5d0 PVP\ub97c \ucca8\uac00\ud55c \uacbd\uc6b0, \uc81c\ud488\uc758 \ubd84\ub9d0\ub3c4\ub294 5 \ub9c8\uc774\ud06c\ub860 \ubbf8\ub9cc\uc774\uc5c8\uc2b5\ub2c8\ub2e4. \ud604\ud0c1\uc561\uc758 \uc77c\ubc18\uc801\uc778 \ubcf5\uc6a9\ub7c9\uc740 0.1% ~ 1%\uc785\ub2c8\ub2e4.
\uc0bc. \ucea1\uc290\uc5d0 PVP \uc801\uc6a9
\ucea1\uc290\uc744 \ucda9\uc804\ud560 \ub54c \uc911\ub825\uc774 \uc791\uace0 \uc815\uc804\uae30 \ud6a8\uacfc\uac00 \ubc1c\uc0dd\ud558\uae30 \uc26c\uc6b4 \uac00\ubcbc\uc6b4 \uc8fc\uc57d \ubd84\ub9d0\uc744 1%~2% PVP \uc5d0\ud0c4\uc62c \uc6a9\uc561\uc5d0 \ucca8\uac00\ud558\uba74 \uacfc\ub9bd\ud654\uc5d0 \ub3c4\uc6c0\uc774 \ub418\uc5b4 \ubd84\ub9d0\uc758 \ud750\ub984 \uc131\ub2a5\uc744 \ud5a5\uc0c1\uc2dc\ud0a4\uace0 \ucda9\uc804\uc744 \ucd09\uc9c4\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc678\uad6d\uc5d0\uc11c\ub294 PVP\uac00 \uc2dc\ud074\ub85c\ub9cc\ub378\ub808\uc774\ud2b8, \ud504\ub85c\ud544\ud53c\ub77c\ubbfc, \ud53c\ub9ac\ub3c5\uc138\uc774\ud2b8, \uc5d0\ud2f8\uc591\uadc0\ube44 \uc9c0\uc18d\ud615 \ucea1\uc290 \ub4f1\uacfc \uac19\uc740 \uacbd\uc9c8 \ucea1\uc290 \ubd80\ud615\uc81c\ub85c \uc0ac\uc6a9\ub418\uc5b4 \uc654\uc2b5\ub2c8\ub2e4. \uac00\uad50\ub41c PVP(PVPP)\ub294 \ud574\uc5f4 \uc9c4\ud1b5\uc81c\uc778 \ucf00\ud1a0\ub864\ub77d \uc544\ubbf8\ub178\ud2b8\ub9ac\uc62c(ketorolacaminotriol)\uc778 \uac83\uc73c\ub85c \ubcf4\uace0\ub418\uc5c8\uc2b5\ub2c8\ub2e4.
\uc5f0\uc9c8 \ud3a0\ub81b\uc758 \uc81c\uc81c\ud654\uc5d0 PVP\ub97c \uc801\uc6a9\ud55c \ubcf4\uace0\ub294 \uac70\uc758 \uc5c6\uc2b5\ub2c8\ub2e4. \uc77c\ubcf8 \ud654\ud559\uc81c\uc57d\ud68c\uc0ac\uac00 \ub2c8\ud2b8\ub85c\ud398\ub2c8\ub518 \uc5f0\uc9c8\ud3a0\ub9bf\uc744 \uc81c\uc870\ud560 \ub54c \ubd84\uc0b0\uc81c\ub85c \uc18c\ub7c9\uc758 PVP(\uc57d 0.2%)\ub97c \ucca8\uac00\ud558\uc600\ub2e4.
4. \uc548\uc57d \ubc0f \uae30\ud0c0 \uc194\ub8e8\uc158\uc5d0 PVP \uc801\uc6a9
\uc548\uc57d\uc5d0 \uc77c\uc815\ub7c9\uc758 PVP\ub97c \ucca8\uac00\ud558\uba74 \uc548\uc57d\uc758 \uc790\uadf9\uc744 \uc904\uc774\uace0 \uc57d\ubb3c\uc774 \ub208\uc5d0 \uba38\ubb34\ub294 \uc2dc\uac04\uc744 \uc5f0\uc7a5\ud558\uba70 \uce58\ub8cc \ud6a8\uacfc\ub97c \ud5a5\uc0c1\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4. PVP\ub294 \uce5c\uc218\uc131\uc774\ubbc0\ub85c \ucf58\ud0dd\ud2b8\ub80c\uc988 \ucc29\uc6a9\uc790\uc758 \ud3b8\uc548\ud568\uc744 \ub290\ub084 \uc218 \uc788\uc73c\uba70 \uc778\uacf5\ub208\ubb3c \uc5ed\ud560\ub3c4 \ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.
\ucd5c\uadfc\uc5d0\ub294 \ucf54\uc810\ub9c9 \ud22c\uc5ec\uac00 \uc8fc\ubaa9\uc744 \ubc1b\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ud504\ub85c\ud504\ub77c\ub180\ub864\uacfc \uac19\uc774 \uac04 \ud1b5\uacfc \ud6a8\uacfc\uac00 \ud06c\uac70\ub098 \uc704\uc7a5\uc5d0 \uc790\uadf9\uc744 \uc8fc\ub294 \uc57d\ubb3c\uc758 \uacbd\uc6b0 \ube44\uac15 \uc810\ub9c9 \ud22c\uc5ec\ub97c \uc0ac\uc6a9\ud558\uc5ec \uc804\uc2e0 \uc5ed\ud560\uc744 \ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ube44\uac15 \uc810\ub9c9\uc5d0 \ub300\ud55c \uc57d\ubb3c\uc758 \uc790\uadf9\uc744 \uc904\uc774\uace0 \ud6a8\uacfc\ub97c \uc5f0\uc7a5\uc2dc\ud0a4\uae30 \uc704\ud574. \ucf54\uc810\ub9c9\uc5d0\ub3c4 \uc77c\uc815\ub7c9\uc758 PVP\ub97c \ucd94\uac00\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.
PVP\ub294 \uc2dc\ub7fd\uc6a9 \ud604\ud0c1\uc81c\ub85c\ub3c4 \uc0ac\uc6a9\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.
\ub2e4\uc12f. \uc57d\ubb3c \uc6b4\ubc18\uccb4\ub85c\uc11c\uc758 PVP
5.1 PVP\ub294 \ubd88\uc6a9\uc131 \uc57d\ubb3c\uacfc \uace0\uccb4 \ubd84\uc0b0\uccb4\ub97c \ud615\uc131\ud569\ub2c8\ub2e4.
\uace0\uccb4\ubd84\uc0b0\uccb4\ub294 \ud6a8\uacfc\uac00 \ube60\ub974\uace0 \uc0dd\uccb4\uc774\uc6a9\ub960\uc774 \ud5a5\uc0c1\ub418\uc5b4 \uc9c0\ub09c 30\ub144\uac04 \uc77c\uc815\ud55c \ubc1c\uc804\uc774 \uc788\uc5c8\uc2b5\ub2c8\ub2e4. \ud604\uc7ac \uc911\uad6d\uc5d0\uc11c \uc5f0\uad6c \ubc0f \uc801\uc6a9\ub418\ub294 \ud488\uc885\uc774 \uc810\ucc28 \uc99d\uac00\ud558\uace0 \uc788\uc73c\uba70 PVP\ub294 \uace0\uccb4 \ubd84\uc0b0\uccb4\uc758 \uc8fc\uc694 \ub2f4\uccb4\ub85c \ub110\ub9ac \uc0ac\uc6a9\ub429\ub2c8\ub2e4. PVP\ub97c \ub2f4\uccb4\ub85c \uc0ac\uc6a9\ud558\uc5ec \ubc14\ub2d0\ub9b0, PVP(1:10) \ub4f1\uc758 \uc57d\ubb3c\uacfc \uacf5\uce68\uc804\uc744 \ud615\uc131\ud560 \uacbd\uc6b0 \uc6a9\ud574\ub3c4\ub294 4.08 mg\/mL\ub85c 10\ubd84 \ub9cc\uc5d0 82%\uac00 \uc6a9\ud574\ub418\ub294 \ubc18\uba74, \ubc14\ub2d0\ub9b0\uacfc PVP(1) :10) \uae30\uacc4\uc801 \ud63c\ud569\ubb3c \ub610\ub294 \uc21c\uc218 \ubc14\ub2d0\ub9b0, \ub458 \ub2e4 \uc6a9\ud574\ub418\uc9c0 \uc54a\uc74c.
\uace0\uccb4 \ubd84\uc0b0\uccb4\uc758 \uc57d\ubb3c \ubc29\ucd9c \uc18d\ub3c4\ub294 PVP\uc758 \ubd84\uc790\ub7c9(\uc911\ud569\ub3c4)\uc774\ub098 \ud22c\uc5ec \ube44\uc728\uc744 \ubcc0\uacbd\ud558\uc5ec \uc870\uc815\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.
\uc77c\ubc18\uc801\uc778 \uaddc\uce59\uc740 PVP\uc758 \ubd84\uc790\ub7c9\uc774 \uc99d\uac00\ud568\uc5d0 \ub530\ub77c \uc57d\ubb3c\uc758 \uc6a9\ud574 \uc18d\ub3c4\uac00 \uac10\uc18c\ud55c\ub2e4\ub294 \uac83\uc785\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, ST, SMZ \ubc0f SIZ\uc5d0 \uc758\ud574 \uac01\uac01 PVPk15(10000), PVPk30(40000) \ubc0f PVPk90(360,000)\uc73c\ub85c \ud615\uc131\ub41c \ubd84\uc0b0\uc561\uc758 \uc6a9\ud574 \uc18d\ub3c4\ub294 PVPk15>PVPk30>PVPk90\uc785\ub2c8\ub2e4. \uc774 \uaddc\uce59\uc744 \uc900\uc218\ud558\ub294 \uae30\ud0c0 PVP \uace0\uccb4 \ubd84\uc0b0\uccb4\uc5d0\ub294 \ub514\ud788\ub4dc\ub85c\ud074\ub85c\ub85c\ud2f0\uc544\uc9c0\ub4dc, \uc124\ud30c\ud2f0\uc544\uc878, \ud074\ub85c\ub78c\ud398\ub2c8\ucf5c, \ud478\ub85c\uc774\ub4dc, \ub514\uace1\uc2e0, \ud074\ub85c\ub85c\ud2f0\uc544\uc9c0\ub4dc, \ud558\uc774\ub4dc\ub85c\ucf54\ub974\ud2f0\uc190, \uc2a4\ud2b8\ub871 \uc624\ub80c\uc9c0 \ub4f1\uc774 \ud3ec\ud568\ub418\uc9c0\ub9cc, \ub2c8\ud2b8\ub85c\ud398\ub2d0\ub9ac\uc544\uc99d\uacfc \uac19\uc774 \uc774 \uaddc\uce59\uc744 \ub530\ub974\uc9c0 \uc54a\ub294 \uc57d\ubb3c\uc758 \uc77c\ubd80 \uace0\uccb4 \ubd84\uc0b0\uccb4\ub3c4 \uc788\uc2b5\ub2c8\ub2e4. \uc704\uc758 \uc138 \uac00\uc9c0 PVP \ubd84\uc0b0\uc561\uc744 \uc6a9\ud574 \ud14c\uc2a4\ud2b8 \uacb0\uacfc\uc5d0\uc11c \ubcf4\uba74 PVP \ubd84\uc0b0\uc561\uc774 \uac00\uc7a5 \ube60\ub974\uac8c \uc6a9\ud574\ub418\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4. 10% \ud398\ub2c8\ud1a0\uc778-pvp \ubd84\uc0b0\uc561\uc740 PVPk30>PVPk25>PVPk60\uc785\ub2c8\ub2e4. \uc774\ub294 PVP\uac00 \uc57d\ubb3c \ubd84\uc790\uc5d0 \ub124\ud2b8\uc6cc\ud06c\ub97c \ud615\uc131\ud558\ub824\uba74 \ud2b9\uc815 \uc0ac\uc2ac \uae38\uc774(\uc911\ud569 \uc815\ub3c4)\uac00 \ud544\uc694\ud558\uace0 \uc57d\ubb3c\ub9c8\ub2e4 \ub2e4\ub978 PVP \uc0ac\uc2ac \uae38\uc774\uac00 \ud544\uc694\ud558\ubbc0\ub85c PVP\uac00 \uc57d\ubb3c \ubd84\uc790\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uc774 \ub2e4\ub974\uae30 \ub54c\ubb38\uc785\ub2c8\ub2e4. \ub2e4\uc591\ud55c \uc57d\ubb3c\uc758 \uacb0\uc815\ud654 \uc5b5\uc81c.
PVP \ubd84\uc0b0\uc561\uc5d0 \ub300\ud55c \uc57d\ubb3c\uc758 \uc911\ub7c9\ube44\uac00 \ub2e4\ub974\uba74 \uc6a9\ucd9c\ub960\ub3c4 \ub2ec\ub77c\uc9d1\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4 \uc124\ud30c\ubbf8\uc18d\uc0ac\uc878\uacfc PVP\uc758 \uc911\ub7c9\ube44\uac00 10:1\uc778 \uacbd\uc6b0 PVP\uc758 \uc591\uc774 \ub108\ubb34 \uc801\uc5b4\uc11c \uc124\ud30c\ubbf8\uc18d\uc0ac\uc878\uc758 \uacb0\uc815\ud654\ub97c \uc5b5\uc81c\ud560 \uc218 \uc5c6\uc2b5\ub2c8\ub2e4. \uacf5\uce68\uc804\uc744 \ud615\uc131\ud560 \uc218 \uc5c6\uc73c\uba70 \uc77c\ubc18\uc801\uc73c\ub85c 14 \ub610\ub294 1:5(W\/W)\uac00 \uc801\ud569\ud569\ub2c8\ub2e4. \ub610 \ub2e4\ub978 \uc608\ub294 \uc2dc\ud074\ub85c\ud5e5\uc2e4\uc6b0\ub808\uc544 \uc544\uc138\ud1a1\uc2dc-PVP \ubd84\uc0b0 \uc2dc\uc2a4\ud15c\uc73c\ub85c, PVP \ud568\ub7c9\uc774 70% \uc774\uc0c1\uc774\uace0, \uc57d\ubb3c\uc774 \ubb34\uc815\ud615\uc73c\ub85c \ubd84\uc0b0\ub418\uc5b4 \uc6a9\ud574\uac00 \ube60\ub978 \ubc18\uba74, PVP\uac00 70 \ubbf8\ub9cc\uc77c \uacbd\uc6b0 \uc57d\ubb3c \uacb0\uc815\ud654\uac00 \uc99d\uac00\ud558\uace0 \uc6a9\ud574\uac00 \uac10\uc18c\ud569\ub2c8\ub2e4. %. \uadf8\ub9ac\uc138\uc624\ud480\ud540-PVP \ubd84\uc0b0\uc561\uc758 \uc6a9\ud574\uc728\uc740 1:20 > 1:10 > 1:5\uc778 \ubc18\uba74, SF-PVP \uacf5\uc99d\ubc1c\uc758 \uc6a9\ud574\uc728\uc740 1:3 > 1:5 > 1:10 > 1:20\uc774\uc5c8\ub2e4.
5.2 \uc81c\uc5b4 \ubc29\ucd9c \ud544\ub984 \uad6c\uc131\uc694\uc18c
PVP\ub294 \uacbd\ud53c \ud761\uc218 \ud544\ub984\uc758 \uc81c\uc5b4 \ubc29\ucd9c \ud544\ub984 \uad6c\uc131 \uc694\uc18c\ub85c \uc790\uc8fc \uc0ac\uc6a9\ub429\ub2c8\ub2e4. \uc77c\ubc18\uc801\uc778 \uacbd\ud53c \uc57d\ubb3c \uc804\ub2ec \uc2dc\uc2a4\ud15c\uc740 \uc7a5\ucc29\uce35, \uc57d\ubb3c \ub77c\uc774\ube0c\ub7ec\ub9ac, \uc81c\uc5b4 \ubc29\ucd9c \ud544\ub984, \uc811\ucc29\uce35 \ubc0f \ubcf4\ud638 \ud544\ub984\uc758 5\uac1c \uce35\uc73c\ub85c \ub098\ub20c \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ubbf8\uc138 \ub2e4\uacf5\uc131 \ub9c9 \uc81c\uc5b4 \ubc29\ucd9c \uc2dc\uc2a4\ud15c\uc758 \uacbd\uc6b0 \uc81c\uc5b4 \ubc29\ucd9c \uc694\uc18c\ub85c \uc870\ubc00\ud558\uac70\ub098 \ub2e4\uacf5\uc131 \ud544\ub984\uc744 \uc0ac\uc6a9\ud558\uace0 \uc57d\ubb3c \uc800\uc7a5\uc18c\ub294 \uae08\uc18d \ud50c\ub77c\uc2a4\ud2f1 \ubcf5\ud569 \ud544\ub984\uacfc \uc18d\ub3c4 \uc81c\uc5b4 \ud3f4\ub9ac\uba38 \ud544\ub984\uc73c\ub85c \uc131\ud615\ub41c \uc791\uc740 \ud480\ub85c \ud3ec\uc7a5\ub429\ub2c8\ub2e4. \uc800\uc7a5\uc18c\uc5d0 \uc788\ub294 \uc57d\ubb3c \uace0\ud615\ubb3c\uc758 \uc77c\ubd80\ub294 \uace0\uccb4 \ub9e4\uc9c8\uc5d0 \ucf54\ud305\ub41c \ubc18\uc8fd \uac19\uc740 \ud604\ud0c1\uc561\uc774\uac70\ub098 \uc0c8\uc5b4 \ub098\uc62c \uc218 \uc5c6\ub294 \uc810\uc131 \ub9e4\uc9c8\uc5d0 \ud604\ud0c1\ub41c \uac83\uc785\ub2c8\ub2e4. \uc81c\uc5b4 \ubc29\ucd9c \ud544\ub984\uc740 \ubbf8\uc138 \ub2e4\uacf5\uc131 \ub610\ub294 \ube44\ub2e4\uacf5\uc131 \ud3f4\ub9ac\uba38 \ud544\ub984\uc758 \uce35\uc73c\ub85c, \uc57d\ubb3c\uc5d0 \ub300\ud55c \ud2b9\uc815 \ud22c\uacfc\uc131\uc744 \uac00\uc9c0\uba70 \uc81c\uc5b4 \ubc29\ucd9c \ud544\ub984\uc758 \ud3f4\ub9ac\uba38 \uc720\ud615(\uc77c\ubc18\uc801\uc73c\ub85c \uc0ac\uc6a9\ub418\ub294 \ud558\uc774\ub4dc\ub85d\uc2dc\uc5d0\ud2f8 \uc140\ub8f0\ub85c\uc624\uc2a4, \ud558\uc774\ub4dc\ub85d\uc2dc\ud504\ub85c\ud544 \uc140\ub8f0\ub85c\uc624\uc2a4, PVP, \ud3f4\ub9ac\ube44\ub2d0 \uc54c\ucf54\uc62c)\uc744 \uc81c\uc5b4\ud558\uc5ec \uc81c\uc5b4\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub4f1), \uc810\ub3c4 \uc218\uc900, \ud544\ub984 \ub0b4 \uc57d\ubb3c \ubc29\ucd9c \ube44\uc728. Bhallaet al. \ud074\ub85c\ud2b8\ub77c\ubbf8\ud1a4 \ub9d0\ub808\uc5d0\uc774\ud2b8\uc758 \uacbd\ud53c \ud544\ub984\uc81c\ub97c \uc5f0\uad6c\ud558\uace0, PVA, PVP \ubc0f \uae00\ub9ac\uc138\ub864 \ub610\ub294 \ud3f4\ub9ac\ube44\ub2d0 \uc54c\ucf54\uc62c\ub85c \ud615\uc131\ub41c \ud544\ub984\uc744 \uc57d\ubb3c\uc758 \uacbd\ud53c \ud761\uc218 \uc81c\uc81c\uc758 \uc911\ud569\uccb4 \ub9e4\ud2b8\ub9ad\uc2a4\ub85c \uc0ac\uc6a9\ud588\uc2b5\ub2c8\ub2e4. \uadf8 \uacb0\uacfc, PVP\uc758 \ub18d\ub3c4\ub97c \ub192\uc774\uac70\ub098 \uac00\uc18c\uc81c\uc758 \uc591\uc744 \ub298\ub9ac\uba74 \uacbd\ud53c\ud761\uc218\uac00 \uc99d\uac00\ud560 \uc218 \uc788\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\ub2e4.
\uc7a5\ubc29\ucd9c\ud615 \uc544\uc774\ud544\ub984 \uc2dc\ud5d8\uc0dd\uc0b0\uc5d0\uc11c \uc81c\uc5b4\ubc29\ucd9c\uce35\uc5d0 \ubaa8\uacf5\uc720\ubc1c\uc81c\ub85c PVP\ub97c \ucca8\uac00\ud588\ub294\ub370, \uc774\ub294 \uc5d0\ud2f8\ub80c\ube44\ub2d0\uc544\uc138\ud14c\uc774\ud2b8 \uacf5\uc911\ud569\uccb4(EVA)\uc640 \uc798 \ud63c\ud569\ub420 \uc218 \uc788\uc5c8\uace0, \uc81c\uc791\ub41c \uc544\uc774\ud544\ub984\uc740 \ubcf4\ub2e4 \ubc1d\uace0 \ubd80\ub4dc\ub7ec\uc6e0\ub2e4. \ub371\uc2a4\ud2b8\ub9b0\uc73c\ub85c \ub9cc\ub4e0 \uac83\uc785\ub2c8\ub2e4.
5.3 Others
PVP\ub294 \ub2e4\ub978 \uc81c\ud615\uc5d0\ub3c4 \uc0ac\uc6a9\ub418\uba70, PVP\uac00 \uad6c\uac15 \uc810\ub9c9\uc6a9 \uc5f0\uace0 \uae30\uc7ac \ubc0f \uc784\ud50c\ub780\ud2b8 \ub2f4\uccb4\ub85c \uc0ac\uc6a9\ub420 \uc218 \uc788\ub294 \uac83\uc73c\ub85c \ubcf4\uace0\ub418\uc5c8\uc2b5\ub2c8\ub2e4. PVP\ub294 \uc6b0\uc218\ud55c \ud53c\ub9c9\ud615\uc131\uacfc \ud654\ud559\uc801 \uc548\uc815\uc131\uc73c\ub85c \uc778\ud574 \ub9c8\uc774\ud06c\ub85c\ucea1\uc290\uc6a9 \uc218\uc6a9\uc131 \ucea1\uc290\uc18c\uc7ac\ub85c\ub3c4 \ud65c\uc6a9\uc774 \uac00\ub2a5\ud558\uba70, \ucea1\uc290\uc758 \ub450\uaed8\ub97c \ubcc0\ud654\uc2dc\ucf1c \uc57d\ubb3c\ubc29\ucd9c\uc744 \uc870\uc808\ud560 \uc218 \uc788\ub2e4.
\uc694\ucee8\ub300, PVP\uc758 \uc751\uc6a9 \uc804\ub9dd\uc740 \uad11\ubc94\uc704\ud569\ub2c8\ub2e4. \uce5c\uc218\uc131\uacfc \uc18c\uc218\uc131 \ud2b9\uc131\uc73c\ub85c \uc778\ud574 \uc911\ud569 \uc815\ub3c4\uc5d0 \ub530\ub77c \ub2e4\uc591\ud55c \ubd84\uc790\ub7c9\uc758 \uc81c\ud488\uc774 \ub9cc\ub4e4\uc5b4\uc9c8 \uc218 \uc788\uace0 \ud654\ud559\uc801 \uc548\uc815\uc131\uc774 \uc788\uc5b4 \uc758\uc57d\ud488 \uc81c\uc81c, \ud2b9\ud788 \uace0\uccb4\uc5d0 \uc0ac\uc6a9\ub418\ub294 \uc0c8\ub85c\uc6b4 \ubcf4\ucda9\uc81c\ub85c \uc0ac\uc6a9\ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4. PVP \uc2dc\ub9ac\uc988 \uc81c\ud488\uc740 \uc12c\uc720, \uc544\ud06c\ub9b4 \uc5d0\uc2a4\ud14c\ub974 \ub4f1\uacfc \ud568\uaed8 \ub110\ub9ac \uc0ac\uc6a9\ub420 \uac83\uc785\ub2c8\ub2e4. \uc774\ub294 \uc911\uad6d \uc758\uc57d\ud488 \uc81c\uc81c\uac00 \uad6d\uc81c \uc120\uc9c4 \uc21c\uc704\uc5d0 \uc9c4\uc785\ud558\ub294 \ub370 \uc801\uadf9\uc801\uc778 \uc5ed\ud560\uc744 \ud558\uba70 \uc911\uad6d \uc81c\uc57d \uc0b0\uc5c5 \ubc1c\uc804\uc5d0 \uc0c1\ub2f9\ud55c \uacf5\ud5cc\uc744 \ud569\ub2c8\ub2e4.<\/p>","protected":false},"excerpt":{"rendered":"

PolyvinylPyrrolidone, English name: PolyvinylPyrrolidone, referred to as PVP, is an excellent performance, a wide range of non-ionic water-soluble polymer fine chemicals, from N-vinylpyrrolidione (N-Vinylpyrrolidione, referred to as NVP) by free radical polymerization. PVP has many excellent physical and chemical properties, such as excellent solubility, low toxicity, film forming, solubilization, complexation, physiological compatibility, surface activity and chemical stability.\u3010 Key words \u3011 POvidone, medicinalWith the development of pharmaceutical preparation technology, POvidone has been used more and more widely as pharmaceutical excipients of non-ionic water-soluble polymer compounds.The excellent physiological compatibility of POvidone series of pharmaceutical excipients is its inherent and unique product properties, and now it has become the three main synthetic pharmaceutical excipients together with cellulose derivatives and acrylic compounds.Povidone series can be divided into a variety of models according to different K values, of which the most widely used varieties are K15, K30 and K90. The Chinese Pharmacopoeia only lists the\u2026<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"attr":[120],"class_list":["post-1673","post","type-post","status-publish","format-standard","hentry","category-problems"],"_links":{"self":[{"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/posts\/1673","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/comments?post=1673"}],"version-history":[{"count":1,"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/posts\/1673\/revisions"}],"predecessor-version":[{"id":1675,"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/posts\/1673\/revisions\/1675"}],"wp:attachment":[{"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/media?parent=1673"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/categories?post=1673"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/tags?post=1673"},{"taxonomy":"attr","embeddable":true,"href":"https:\/\/www.yearnintl.com\/ko\/wp-json\/wp\/v2\/attr?post=1673"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}