use of dmso in drug preparation

Dimethyl sulfoxide (‌DMSO) ‌ is widely used in drug preparation, ‌ mainly includes improving solubility and permeability of drugs, ‌ developing new routes of drug delivery, ‌ increasing local drug content and reducing side effects of drugs. ‌

As a weak oxidizing agent, ‌ is soluble and permeable to many drugs, ‌ which makes DMSO an important solvent in drug preparation. ‌DMSO itself also has anti-inflammatory, ‌ analgesic, ‌ promote blood circulation and wound healing, ‌ diuretic and sedative effects, ‌ can increase drug absorption and improve curative effect. ‌ When the drug is dissolved in DMSO, ‌ does not need to be taken orally or injected, ‌ can be directly applied on the skin to penetrate into the body, ‌ not only opens up a new way of drug delivery, ‌ but also increases the local drug content in the disease area, ‌ reduces the harm to other parts of the body. ‌ In addition, ‌DMSO has the property of dissolving keratin, ‌ makes it have remarkable effect in improving the therapeutic effect of drugs, ‌ especially in inhibiting the growth of tumor. ‌

There are various production methods for DMSO, ‌ including methanol carbon disulfide process, ‌ hydrogen peroxide process, ‌ nitrogen dioxide process, etc. ‌ these methods provide possibilities for large-scale production of DMSO. ‌ The refining methods include vacuum distillation, ‌ and CaH2 heating, ‌ molecular sieve dehydration, ‌ to ensure the purity and quality of DMSO. ‌

Despite the many advantages of DMSO, ‌, there are also safety precautions that need to be taken during use. ‌ should be avoided long-term skin contact with DMSO, ‌ because of its small molecular weight, ‌ easily absorbed through the skin, ‌ may lead to local skin irritation, ‌ itching, ‌ burning sensation. ‌ At the same time, ‌ should also avoid inhaling DMSO, ‌ to avoid nausea, ‌ vomiting and other uncomfortable symptoms. ‌

The application of DMSO in drug preparation not only improves the solubility and permeability of the drug, ‌ opens up a new route of drug delivery, ‌ but also increases the local drug content in the disease area and ‌ reduces the side effects of the drug on the body. ‌ However, ‌ requires safety precautions during use and ‌ to avoid possible side effects. ‌
The role of dimethyl sulfoxide in pharmaceutical
Colorless viscous liquid. Flammable, almost odorless, bitter, hygroscopic. In addition to petroleum ether, it can dissolve general organic solvents.
Strong hygroscopic, at 20 ° C, when the relative humidity is 60%, it can absorb 70% of its own weight from the air. The product is a weak oxidizing agent, and the non-aqueous dimethyl sulfoxide is non-corrosive to metals.
DMSO는 많은 약물에 용해성 및 투과성을 가지며 항염증성, 진통성, 혈액순환 촉진 및 상처치유 촉진, 이뇨 및 진정 효과가 있으며 약물 흡수를 증가시키고 치료 효과를 향상시킬 수 있습니다. 약물은 DMSO에 용해되어 피부에 바르면 경구투여나 주사 없이 인체에 침투할 수 있어 새로운 약물 전달의 길을 열었으며, 더 중요한 것은 질병 부위의 국소 약물 함량을 높이고 유해성을 줄이는 것입니다. 신체의 다른 기관에 있는 약물.