폴리비닐피롤리돈 K90

상품 설명

폴리비닐피롤리돈(PVP)은 저분자량에서 고분자량까지 다양한 점도 수준으로 시판되는 비이온성 폴리머입니다. 이러한 분류는 수용성/유기 용매 시스템에서의 용해도, 무독성 특성, 산, 염분 및 열에 대한 안정성과 결합되어 PVP 적용에 큰 유연성을 제공합니다. PVP의 산업적 응용에는 예를 들어 강도와 두께를 향상시키기 위한 접착제로 사용되는 것; 종이 생산의 강도를 높이십시오. 수지 코팅으로 사용됩니다. 합성 섬유의 변성 염료; 또한 잉크, 이미징, 석판 인쇄, 세제 및 비누, 직물, 도자기, 전기, 야금 및 폴리머 첨가제로 일반적으로 사용됩니다. 우수한 접착력, 필름 형성, 분산 및 증점 특성으로 인해 PVP는 제약 산업에서도 널리 사용됩니다.

PVP는 평균 분자량 크기에 따라 분류되며 일반적으로 K 값으로 표시되며, 다른 K 값은 PVP의 다른 평균 분자량 범위를 나타냅니다. K값은 실제로 PVP 수용액의 상대점도에 관련된 특성값이고, 점도는 고분자의 분자량에 관련된 물리적 값이므로 PVP의 평균분자량은 K값으로 특성화할 수 있다. 일반적으로 K 값이 클수록 점도가 높아집니다.

This product is Polyvinylpyrrolidone K90 (Polyvinylpyrrolidone K90), referred to as PVP-90, with an average molecular weight of 1,300,000.

제품특성

1) CAS NO: 9003-39-8

2) Synonymous name: Polyvinylpyrrolidone K90; Polyvidone; Povidone; Povidone; Polyn-vinylbutylactam;

3) Linear molecular formula: (C6H9NO)n

4) Average molecular weight: 1,300,000

5) K value: K88-96

6) Appearance: white to light yellow powder

7) Solubility: easily soluble in water, alcohol, amine and halogenated hydrocarbons; Insoluble in acetone, ether, etc.

Preservation and transportation methods

Storage: Store dry at room temperature for at least 3 years.

Transportation: room temperature transportation.

Matters needing attention

For your safety and health, please wear a lab coat and disposable gloves.

Polyvinylpyrrolidone (PVP) is a water-soluble polymer with good biostability, chemical stability, low toxicity and good biocompatibility. Therefore, it is of great benefit in various applications such as cosmetics, tissue engineering and biomedical engineering.
The specific application of polyvinylpyrrolidone in various industries
1. 경구 고형 제제용 접착제
PVP is soluble in water and some commonly used organic solvents, making it suitable for use in many situations. First of all, in the drug sensitive to humidity and heat, the use of PVP ethanol solution as a binder can eliminate the influence of water and heat, and for hydrophobic drugs, its aqueous solution can be uniformly wetted, and the surface of drug particles can be hydrophilic, which is conducive to increasing the dissolution of drugs. In addition,PVP as an adhesive can be added with dry powder, wetting granulating with appropriate solvent or direct pressing of dry adhesive can improve the phenomenon of hydrophobic drug stripping. K30 and K25 are commonly used, and the amount of PVPK30 is generally 2%-5%.
In the use of effervescent agents,PVP is an ideal adhesive, because effervescent agents require strict control of water content, using PVP ethanol solution as a binder can solve this problem. The effervescent tablets made by this method have good obviousness, rapid dissolution and strong foaming. With about 5%-10% PVP solution as binder can also be used for fluidized bed spray drying granulation.
2, 두껍게하고 점성을 높이기 위해 경구 액제에 사용됩니다.
PVP는 경구 액제의 증점제로서 오랜 역사를 가지고 있으며 유제 및 현탁액과 같은 광범위한 응용 분야를 가지고 있습니다. PVPK-90은 우수한 증점 안정제로 사용할 수 있으며 중합체는 단일 표면에 흡착됩니다. 콜로이드 이온이 얇은 분자층을 형성하여 응집을 방지합니다.
3, 고체 분산 캐리어로 사용
생체 내에서 불용성 약물의 흡수를 향상시키는 것은 항상 뜨거운 주제였으며, 이 목적을 달성하기 위해 용해도 및 용해 속도를 향상시키는 것을 고려합니다. 고체 분산체는 물에 분산된 분자, 콜로이드, 미정질 또는 무정형 형태의 불용성 약물입니다. 가용성 물질은 용해 속도와 흡수를 크게 향상시킬 수 있습니다. PVP는 식생 고체 분산의 일반적인 운반체입니다.
PVP is better as a solid dispersion carrier of carvedilol. PEG-6000 and PVP are commonly used solid dispersion carriers, which basically do not interfere with the determination of main drugs. After carvedilol was treated with solid dispersion technology, the dissolution rate in vitro and bioavailability in vivo were significantly increased, which provided an effective way for carvedilol to be prepared into highly effective preparations.
4, used as film coating material
Usually the standard PVP can be used as a medicinal film forming material or combined with other film materials because of its ideal flexibility. Practice has proved that PVP can be used in the film coating process of both water and organic solvent systems, and its coating advantages: it can improve the adhesion ability of the film to the surface, improve the dispersion of color lake or dye, can be used as a film plasticizer, and can change the disintegration time of the film based on hydrophobic materials. The commonly used concentration of coating is 0.5%– 5%. At present, PVP/VA series products are specially used as film forming materials, which are copolymers of VP(vinylpyrinolanone) and VA(vinyl acetate).
5, used in slow-release preparations
PVP can be used as adhesive, blocking agent, osmotic enhancer and so on. Ye Linlin et al. [8] developed single-chamber single-layer nifedipine oral osmotic pump tablets, optimized the formula and preparation parameters of nifedipine oral osmotic pump tablets, and determined the core formula, in which the content of PVP as an osmotic aid was 7.08%. The results showed that the release of nifedipine osmotic pump tablets prepared by the authors was in good agreement with the characteristics of zero-order release of osmotic pump tablets.
6, PVPK series is one of the excellent medicinal synthetic new excipients, mainly used as a binder for tablets, pills and granules, co-solvent for injections, flow aid for capsules, co-precipitation agent for refractory drugs, detoxification of eye drugs and lubricants.
7, polyvinylpyrrolidone /PVP-K series products
화학명: 폴리비닐피롤리돈
CTFA 이름 :폴리비닐피롤리돈(PVP)
Properties: Powder or aqueous solution,PVP is easily soluble in water, alcohol, amine and halogenated hydrocarbons, insoluble in acetone, ether and so on. It has excellent solubility, biological compatibility, physiological inertness, film forming, membrane protection ability and the ability to compound with a variety of organic and inorganic compounds, and is stable to acid, salt and heat, so it has a wide range of uses.
Application of PVP in industrial and high-tech fields :PVP can be used as surface coating agent, dispersant, thickener and adhesive in pigment, printing ink, textile, printing and dyeing, color picture tube. PVP can improve the bond performance of binder to metal, glass, plastic and other materials, and PVP in the separation film, medical polymer materials, light solid resin, light solid coating, optical fiber, laser disc and other emerging high-tech fields are also increasingly widely used
8, the application of medicinal grade PVP(POvidone)
Povidone is widely used in medicine and is one of the three new pharmaceutical excipients advocated internationally. The most widely used adhesives are tablets and granules. PVP can also be used as a flow aid for capsules, a detoxifying agent and lubricant for eye drugs, a co-solvent for injections, a dispersant for liquid preparations, and a stabilizer for enzymes and heat-sensitive drugs. Povidone can also synthesize PVP-I disinfectant with iodine. In contact lenses,PVP is used as a component of contact lenses to increase their hydrophilicity. PVP can also be used as a cryogenic preservative in medicine.