In the daily use of cosmetics ingredient list, often see propylene glycol this substance. Some labels are 1, 2-propylene glycol, others are 1, 3-propylene glycol, so what’s the difference between the two? 1, 2-propylene glycol, CAS number 57-55-6, molecular formula C3H8O2. It is a chemical reagent, miscible with water, ethanol and various organic solvents. Normally, it is a colorless viscous liquid, almost odorless, and slightly sweet. It can be used as a wetting agent in combination with glycerin or sorbitol in cosmetics, toothpaste and soap. It is used in hair dye as a moisture conditioner, hair levelling agent, and also as an antifreeze. 1, 3-propylene glycol, CAS 504-63-2, molecular formula C3H8O2. Colorless, odorless, salty, hygroscopic viscous liquid, can be oxidized, esterification reaction, can be miscible with water, can be miscible in ethanol, ether. It can be used for the synthesis of many drugs, new polyester PTT, pharmaceutical intermediates and new…

Dimethyl sulfoxide is an important osmotic cell protectant. It is necessary to use a cryoprotectant containing DMSO in order to prevent damage caused by the formation of intracellular liquid ice crystals, osmotic pressure changes, and cell structure disorders during the cryopreserved process of cells at a deep temperature (minus 200 degrees Celsius).DMSO can quickly penetrate the cell membrane into the cell, reduce the freezing point, delay the freezing process, increase the concentration of intracellular ions, reduce the formation of intracellular ice crystals, and thus reduce cell damage.​The cytotoxicity of dimethyl sulfoxide is inhibited at deep low temperature, and the action should be fast during resuscitation to wash off dimethyl sulfoxide as soon as possible, otherwise it will cause serious toxicity to cells.Dimethyl sulfoxide (DMSO) is the best protective agent for cell cryopreserved, but it is also a chemical test agent with high cytotoxicity. The results show that when the concentration…

polyvinylpyrrolidone (PVP), a non-ionic polymer, is the most distinctive, best-studied and most widely studied fine chemical among N-vinylamide polymers.PVP is divided into four stages according to its average molecular weight size, which is usually expressed by the K value, and different K values represent the corresponding average molecular weight range of PVP. The K value is actually an eigenvalue related to the relative viscosity of PVP aqueous solution, and the viscosity is a physical quantity related to the molecular weight of polymers, so the average molecular weight of PVP can be characterized by K value.pvp is polyvinylpyrrolidone. PVP was obtained by bulk polymerization and solution polymerization of vinyl pyrrolidone (NVP) as raw material. In the process of bulk polymerization, due to the viscosity of the reaction system, the polymer is not easy to diffuse, and the polymerization heat is not easy to remove, resulting in local overheating.Therefore, the obtained product…

Shanghai Yearn Chemical Science-Tech Co., Ltd In Zhejiang Anji has 20,000 square meters of factory, the production of different specifications and models of polyethylene pyrrolidone, is the manufacturer of polyethylene pyrrolidone, according to the market, the price has changed, if there is an inquiry, welcome to consult the customer service site at any time. Shanghai Yearn Chemical Science-Tech Co., Ltd Aerial view of factory drone PolyvinylpyrrolidoneAbbreviation: POvidone, PVPCAS number :9003-39-8The appearance of PVP is white powder, slightly special smell, hygroscopicity, easy to dissolve in water, alcohol, amine and other organic solvents, with excellent solubility, film formation, chemical stability, adhesion and complexation ability, widely used in usp26 cosmetics and other industries.The cosmetics industryPVP can be used as film agent, thickener, lubricant and adhesive in cosmetics industry for spraying agent, mousse, hair fixing gel; In skin care products and hair dye, modifier, shampoo, lip balm, deodorant, sunscreen, toothpaste and other aspects of…

The odor description of dimethyl sulfoxide (DMSO) varies from a strong odor, similar to that of rotten eggs or garlic, to a slight odor, or even colorless and odorless.This difference may be due to differences in the concentration and purity of DSO from different sources.1. Properties and uses of dimethyl sulfoxideDimethyl sulfoxide (DMSO) is a colorless, transparent, organic solvent with excellent solubility and solubility. It is mainly used in organic synthesis, catalytic reaction, REDOX reaction and preparation of polymer materials. In addition, DMSO has certain medicinal value and is used as a drug delivery and efficacy enhancer in pharmacy. Dimethyl sulfoxide tasteAlthough DMSO has a wide range of applications, it is also an organic solvent with a strong odor. It smells similar to rotten eggs or garlic, and can even pass through work clothes and gloves to produce a pungent smell. Therefore, when using DMSO, we must pay attention to…

For insoluble active pharmaceutical components (apis), increasing the dissolution rate is a major challenge in formulation development. The objective of this study was to evaluate the performance of several super disintegrators to improve the dissolution of drugs in wet pellet prescription. The insoluble meloxicam and fenofibrate were used as model drugs. Depending on the amount prescribed, cross-linked Polyplasdone™ has been shown to significantly increase the dissolution rate of insoluble drugs in tablet formulations. The super disintegrators examined in this study are as follows: Crosslinked Polyplasdone™; Another crosslinked povidone (1,2); Crosslinked sodium carboxymethyl cellulose; Sodium carboxymethyl starch; Low substituted hydroxypropyl cellulose (L-HPC) Because the Polyplasdone™XL and Ultra specifications are identical in terms of physical and chemical properties (differing only in impurity content), they will be studied interchangeably in this article. The other cross-linked POvidone 1 and 2 differ only in particle size, and the interchange study was also carried out. Test…

First, the characteristics of POvidone as an adhesivePovidone (PVAc) is a colorless, transparent polymer commonly used in the preparation of glues and adhesives. It has good mechanical properties, chemical stability and bonding properties, and can be bonded with cellulose materials, wood, metal and other materials. However, the hydrothermal properties of POvidone are relatively poor, and it is easy to decompose in water, so it is not suitable for bonding work in humid environments. Second, the characteristics of copovidone as an adhesivePolypovidone (PVP/VA) is a copolymer of polyvinylpyrrolidone and polyvinyl alcohol acrylate, which has excellent hydrothermal properties, corrosion resistance and biocompatibility, and is widely used in medical devices, food packaging and cosmetics industries. Compared with POvidone, the mechanical properties of copovidone are slightly inferior, but its hydrothermal stability is strong, it does not decompose in water, and it can perform bonding work in humid environments.The principle of copovidone as a binderCopovidone…

PVP has become a very commonly used pharmaceutical polymer material in pharmaceutical research and development, and its advantages have been more and more recognized, making it a mature multi-purpose pharmaceutical excipients. PVP is a water-soluble polymer catalyzed by N-vinyl-2-pyrinolanone monomer, which is easily hygroscopic and easily soluble in polar organic solvents such as water and ethanol. The molecular weight of medicinal povidone is between 10,000 and 700,000, generally expressed by the size of K, the larger the K, the higher the molecular weight. PVP has many excellent properties, and its application in pharmacy is more and more extensive, more and more applicable, the following is the main aspects of its application in the development and research of pharmaceutical preparations in China. Gage (molecular weight MW)PVPK15 (8,000)PVPK25 (30,000)PVPK30 (50,000)PVPK60 (400,000)PVPK90 (1,000,000)No heat source C Grade PVPK120 (3,000,000) 1. Adhesive for oral solid preparation PVP is soluble in water and some commonly…

As a pharmaceutical excipient, PVP is mainly used as a binder for tablets and granules, a co-solvent for injections, a stabilizer, a dispersing agent for liquid preparations, a coating film forming agent and a pigment dispersing agent, a co-precipitating agent for insoluble drugs, a delayed action agent for ophthalmology, and a lubricant. The main points are described as follows: l, binder: The drug tablet should have a certain mechanical strength so that it will not be broken and maintain good physical properties when it is subjected to the inevitable impact and friction in the process of production, transportation, packaging and sales; At the same time, when taken, it has satisfactory performance characteristics and can quickly disintegrate in the digestive tract and release the drug. The key to solve this problem is to choose the ideal binder. Whether it is wet granule, dry granule or direct tablet process preparation of strong…

Due to the lactam structure in PVP molecules, there is a strong binding force between hydroxyl, amino, and carboxylic groups, and dyes often contain these functional groups, so PVP and general organic dyes have a strong affinity, and sometimes this affinity even exceeds the binding force of dyes and fibers, so PVP is known as “liquid fiber”. Using this property of PVP can increase the affinity between some hydrophobic fibers and dyes, and then improve the dyeability of such fibers, for example, in the synthetic fiber process, the appropriate amount of PVP is mixed into it, so that the synthetic fiber can be evenly dyed, and improve the coloring power and improve the dyeing depth Dyeing more difficult polypropylene fiber, in which the incorporation of about 7.5% of NVP/ styrene copolymer, can make the fiber dyeing depth of acid dyes increased by about 10 times, the dispersive dye can be…