Introduction to the application of pharmaceutical grade POvidone K30

Pharmaceutical grade POvidone K30

Povidone has the properties of bonding, thickening, dispersion, film formation and complexation, so it can be used as a binder for particles and tablets. Co-solvent and stabilizer for injection, film forming agent and pigment dispersing agent for coating, co-precipitation agent for insoluble drug, delay agent and lubricant for ophthalmic drug and sustained release agent for controlled release dosage form, etc.

This product is often used as a tablet adhesive and can dissolve in water and ethanol to become a viscous viscous liquid, which is a good adhesive. PVP has a variety of specifications due to molecular weight or viscosity, the average molecular weight of K30 commonly used in tablet preparation is 6000, and 10%(w/w) aqueous solution has a certain viscosity. For drugs sensitive to moisture and heat, the organic solution of PVP (generally ethanol solution) can be used for granulation, which can avoid the influence of moisture and can be dried at a lower temperature. For hydrophobic drugs, PVP aqueous solution is used as binder, which is not only easy to uniform wet, but also can make the surface of hydrophobic drug particles become hydrophilic, which is conducive to the disintegration and dissolution of drugs. As a binder, water-soluble medicine or solid powder can be used. PVP dry powder can also be used as a direct tablet drying adhesive, 3%~5% Z
The alcohol solution was granulated with dry water-sensitive drugs, and the granules produced were good in compressibility. 5%PVP anhydrous “Alcohol solution can be granulated by the mixed powder of acid and alkali in dry effervescent tablets, which can avoid the biochemical reaction in the presence of water. This product is also an excellent adhesive for chewable tablets.

Pharmaceutical grade POvidone K30

Mividone is a white to milky white, odorless or slightly odorless hygroscopic fine powder. The K value obtained by spray drying is equal to 30
Povidone is spherical. Povidone of grade K90 or higher prepared by rotary drum drying is flaky.
Viscosity and model number

The molecules of POvidone can be characterized by the viscosity of POvidone aqueous solution relative to dry water, expressed by the K value, which ranges from 10 to 120
The K value is calculated using the Fikentschers equation.

The role of povidone in tablets
Povidone is commonly used as a binder in tablets. Povidone is a synthetic polymer. Different degrees of polymerization result in different molecular weights of the polymer. The molecular weight can be characterized by the viscosity of POvidone aqueous solution relative to water. Povidone is widely used as pharmaceutical excipients, especially tablets and solutions. It is not absorbed by gastrointestinal tract and mucosa after oral administration, and is non-toxic, and has no irritation to the skin and no allergic reaction.
Povidone is commonly used as a filler, disintegrator, coating material for tablets, as well as a binder for tablets and granules. In oral and topical preparations, it can be used as a suspension aid, stabilizer or viscosifier. In oral or parenteral administration, it can be used as a solvent, such as the binder of aspirin, vitamin C and sodium bicarbonate tablets, and can delay the hydrolysis of aspirin tablets.
Povidone is generally a white, milky or yellowish hygroscopic powder, odorless or almost odorless. Soluble in ethanol, propylene glycol, acid, chloroform, acetone, methanol and water, insoluble in ethers, alkanes and mineral oil. The hygroscopicity of POvidone is very strong, and the hygroscopicity is also very large at low relative humidity.
Povidone can increase plasma colloid osmotic pressure and expand blood volume, which can be used for hypovolemia caused by trauma bleeding and other reasons. If the patient has trauma bleeding, you can go to the hospital’s internal medicine in time, and the doctor will observe the wound and debridement treatment.